Amoxicillin 20 capsules 500 mg

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Instructions for Amoxicillin

Composition Amoxicillin:

1 capsules contains amoxicillin trihydrate 500 mg.

pharmachologic effect Amoxicillin:

An antibiotic of a group of semisynthetic penicillins with a wide spectrum of action. It is a 4-hydroxyl analogue of ampicillin. Has a bactericidal effect. Active against aerobic gram-positive bacteria: Staphylococcus spp. (with the exception of penicillinase-producing strains), Streptococcus spp; aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. Microorganisms that produce penicillinase are resistant to amoxicillin. In combination with metronidazole, it is active against Helicobacter pylori.
antibiotic is believed to inhibit the development of metronidazole resistance by Helicobacter pylori. There is cross-resistance between amoxicillin and ampicillin. The spectrum of antibacterial action expands with the simultaneous use of amoxicillin and a beta-lactamase inhibitor clavulanic acid. This combination increases the activity of antibiotic against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. However, Pseudomonas aeruginosa, Serratia marcescens, and many other gram-negative bacteria remain resistant.

Indications Amoxicillin:

Bacterial infections caused by pathogens that

are sensitive to Amoxicillin: - acute and chronic infections of the respiratory tract (tonsillitis, acute otitis media, pharyngitis, sinusitis, acute and chronic bronchitis, bronchopneumonia, lung abscess);
- acute and chronic infections of the digestive tract, biliary tract (peritonitis, cholecystitis, intestinal infections);
- acute and chronic infections of the urinary system (pyelonephritis, urethritis, gonorrhea);
- purulent infections of soft tissues;
- sepsis.

Pharmacokinetics Amoxicillin:

When administered amoxicillin is rapidly and completely absorbed from the gastrointestinal tract, is not destroyed in the acidic environment of the stomach. Cmax of antibiotic in the blood plasma is reached in 1-2 hours. With a dose increase of 2 times, the concentration also increases by 2 times. In the presence of food in the stomach does not reduce the total absorption. With the / in, in / m the introduction and ingestion in the blood achieved similar concentrations of amoxicillin. The binding of antibiotic to plasma proteins is about 20%. Widely distributed in tissues and body fluids. High concentrations of antibiotic in the liver are reported. T1 / 2 of plasma is 1-1.5 hours. About 60% of the dose taken orally is excreted unchanged in the urine by glomerular filtration and tubular secretion; at a dose of 250 mg, the concentration of amoxicillin in the urine is more than 300 μg / ml. Some amount of antibiotic is determined in the feces. In newborns and the elderly, T1 / 2 may be longer. In renal failure, T1 / 2 can be 7–20 hours. In small quantities, amoxicillin penetrates the BBB during inflammation of the pia mater. Amoxicillin is removed by hemodialysis

Side effects Amoxicillin:

Allergic reactions: urticaria, erythema, angioedema, rhinitis, conjunctivitis; rarely fever, joint pain, eosinophilia; in rare cases - anaphylactic shock. Effects associated with chemotherapeutic action: possible development of superinfection (especially in patients with chronic diseases or reduced resistance of the body). With prolonged use in high doses: dizziness, ataxia, confusion, depression, peripheral neuropathy, convulsions. Mainly when used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis; rarely, hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, disorders of hemopoiesis.
Mainly when used in combination with clavulanic acid: cholestatic jaundice, hepatitis; rarely erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis

Special conditions Amoxicillin:

With caution used in patients prone to allergic reactions. Amoxicillin in combination with metronidazole is not recommended for use in patients younger than 18 years; should not be used for liver disease. Against the background of combination therapy with metronidazole, alcohol is not recommended.

Contraindications Amoxicillin:

Infectious mononucleosis, lymphocytic leukemia, severe gastrointestinal infections, accompanied by diarrhea or vomiting, respiratory viral infections, allergic diathesis, bronchial asthma, hay fever, hypersensitivity to penicillins and / or cephalosporins. For use in combination with metronidazole: diseases of the nervous system; blood disorders, lymphocytic leukemia, infectious mononucleosis; Hypersensitivity to nitroimidazole derivatives. For use in combination with clavulanic acid: a history of abnormal liver function and jaundice associated with taking amoxicillin in combination with clavulanic acid

Drug interaction Amoxicillin:

Amoxicillin may reduce the effectiveness of oral contraceptives. With the simultaneous use of amoxicillin with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin), synergism is manifested; with bacteriostatic antibiotics (including macrolides, chloramphenicol, linkosamides, tetracyclines, sulfonamides) - antagonism. antibiotic enhances the effect of indirect anticoagulants by suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index. antibiotic reduces the effect of drugs, in the process of metabolism of which PABK is formed. Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs reduce the tubular secretion of amoxicillin, which may be accompanied by an increase in its concentration in blood plasma. Antacids, glucosamine, laxatives, aminoglycosides slow down and decrease, and ascorbic acid increases the absorption of antibiotic.

Dosage Amoxicillin:

Individual. For oral administration, a single dose for adults and children over 10 years old (weighing more than 40 kg) is 250-500 mg, for severe cases of the disease - up to 1 g. For children aged 5-10 years, a single dose is 250 mg; between the ages of 2 and 5 years old - 125 mg; for children under 2 years of age, the daily dose is 20 mg / kg. For adults and children, the interval between doses is 8 hours. In the treatment of acute uncomplicated gonorrhea, 3 g once (in combination with probenecid). In patients with impaired renal function with a CC of 10–40 ml / min, the interval between doses should be increased to 12 hours; when QA is less than 10 ml / min, the interval between doses should be 24 hours.

For parenteral use by adults, intramuscularly, 1 g 2 each, intravenously (at normal renal function) - 2-12 g / Children / m - 50 mg / kg /, single dose - 500 mg, frequency of administration - 2; in / in - 100-200 mg / kg / Patients with impaired renal function, the dose and the interval between doses must be adjusted in accordance with the values of CC.


Active substanceAmoxicillin
Pharmacological groupAntibiotic
Dosage mg500
Pills in 1 package20
Country of originRussia
Expiration Date (in months)Always fresh

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