Diosmin venotonic, [Phlebodia 600] varicosity 600 mg 30 tablets
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Diosmin venotonic, [Phlebodia 600] varicosity 600 mg 30 tablets

SKU:478
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Diosmin venotonic, [Phlebodia 600] varicosity, Angioprotective agent treats varicose veins, hemorrhoids, microcirculation disorders, increases the tone of veins
Active substance:Diosmin
Pharmacological group:Venous Tone
Formulation:Tablets
Dosage mg:600
In stock
$36
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Instructions for Diosmin venotonic, [Phlebodia 600] varicosity 600 mg 30 tablets

Composition Diosmin:

Composition per 1 tablet:

Active ingredient:
diosmin in terms of anhydrous substance - 600,000 mg. Excipients: gelatin - 7.800 mg, sodium carboxymethyl starch (type A) -19.400 mg, magnesium stearate - 9.700 mg, microcrystalline cellulose - up to 970,000 mg. Shell composition: Opadry II 85F240012 Pink - 30,000 mg: polyvinyl alcohol -12,000 mg, macrogol-3350 - 7,314 mg, iron oxide red oxide - 0,120 mg, iron oxide yellow - 0,066 mg, talc - 4,440 mg, titanium dioxide - 6,060 mg .
general description
Angioprotective agent

Special conditions Diosmin:

Treatment of acute hemorrhoids is carried out in combination with other drugs. In the absence of a quick clinical effect, it is recommended to consult a proctologist, if necessary, conduct an additional examination and adjust the therapy.
In case of impaired venous circulation (varicose veins of the lower extremities, chronic lymphovenous insufficiency of the lower extremities), the maximum treatment effect is ensured by a combination of therapy with lifestyle changes: it is advisable to avoid a long stay in an upright position,
reduce overweight. In some cases, wearing special stockings (compression hosiery) helps to improve blood circulation.
The experience with diosmin in children under 18 years of age is insufficient.
If there is no decrease or aggravation of the symptoms of the disease, consult a doctor!
Do not exceed the maximum dates and recommended doses of the drug without consulting your doctor!
Impact on the ability to drive vehicles and mechanisms
The drug does not affect the ability to drive vehicles and mechanisms.

Drug interaction Diosmin:

Clinically significant interactions of diosmin with other drugs have not been described.

Pharmacodynamics Diosmin:

belongs to the group of bioflavonoids, has phlebotonizing (reduces the extensibility of veins, increases venous tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases the resistance of capillaries (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration into paravenous tissues, improves diffusion

oxygen and perfusion in the skin tissue, has an anti-inflammatory effect. Enhances the vasoconstrictor effect of adrenaline, norepinephrine, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.

Pharmokinetics Phlebodia 600: 

Diosmin is rapidly absorbed from the gastrointestinal tract. It is found in blood plasma 2 hours after administration. The bioavailability of the drug after oral administration is approximately 40-57.9%. Part of the drug is metabolized by the bacteria of the cecum with the formation of hippuric and benzoic acids.
The maximum plasma concentration is reached 5 hours after administration. The drug accumulates in all layers of the wall of the vena cava and saphenous veins of the lower extremities, to a lesser extent - in the kidneys, liver and lungs and other tissues. The volume of distribution of the drug is 62.1 liters. The maximum selective accumulation of diosmin and / or its metabolites in the wall of venous vessels is observed 9 hours after ingestion and remains for 96 hours.
Diosmin is rapidly metabolized in the liver. The main metabolite is hydroxyphenylpropionic acid. Diosmin metabolites are excreted mainly by the kidneys in the form of conjugates with glucuronic acid. 79% of the taken diosmin is excreted by the kidneys, 11% - by the intestines, 2.4% - with bile. Enterohepatic circulation of the drug is noted. After taking diosmin labeled with a radioactive isotope, approximately 86% of the drug is excreted by the kidneys and intestines within 48 hours.

Indications Phlebodia 600:

Varicose veins of the lower extremities (elimination of symptoms);
Chronic lymphatic venous insufficiency of the lower extremities (elimination of symptoms);
Acute hemorrhoids (in complex therapy to relieve symptoms);
Violations of microcirculation (for example, with idiopathic edema).

Contraindications Diosmin:

Increased sensitivity to the components of the drug;
Children under 18 years of age (experience with use is limited);
Pregnancy (I trimester) and the period of breastfeeding (experience with use is limited).
Use during pregnancy and during breastfeeding
Experience with the drug in pregnant women is limited. No adverse reactions have been reported with the use of diosmin in pregnant women in clinical practice. In experimental studies, there was no teratogenic effect of diosmin on pregnancy, embryofetal and postnatal development. However, for safety reasons, the use of the drug in the first trimester of pregnancy is contraindicated. If it is necessary to use the drug during the II and III trimesters of pregnancy, it is recommended to consult a doctor first.
During breastfeeding, taking the drug is not recommended, because there is no data on the penetration of diosmin into breast milk.

Overdose Diosmin:

Cases of overdose are not described. Given the wide therapeutic range of diosmin, the risk of intoxication with an overdose appears to be negligible. The specific antidote is unknown.
In case of an overdose of the drug Diosmin, immediately seek medical help!

Side effects Diosmin:

The frequency of side effects is determined in accordance with the WHO classification of adverse drug reactions according to the frequency of occurrence: very often - more than 1/10, often more than 1/100 and less than 1/10, infrequently - more than 1/1000 and less than 1/100, rarely more than 1/10000 and less than 1/1000, very rarely - less than 1/10000, including isolated cases; unknown frequency (it is impossible to determine the frequency of occurrence of an undesirable reaction from the available data).
From the gastrointestinal tract, often - nausea, vomiting, diarrhea (diarrhea), dyspeptic disorders, heartburn, constipation; infrequently - pricks.
From the central nervous system: rarely - headache, dizziness.
On the part of the skin and subcutaneous fat: rarely - skin rashes, skin itching;
Allergic reactions: rarely - urticaria, unknown frequency - isolated swelling of the face, lips, eyelids; in exceptional cases, angioedema (Quincke's edema).
General disorders: rarely - malaise.
If any of the side effects indicated in the instructions are aggravated, or if you notice any other side effects not listed in the instructions, inform your doctor.

Ways of application Phlebodia 600:

The drug Diosmin is intended for oral administration.

With varicose veins of the lower extremities and chronic lymphovenous insufficiency

The drug is used 1 tablet per day in the morning on an empty stomach. The duration of therapy is usually 2 months. In severe forms of chronic lymphovenous insufficiency (edema, pain, cramps, etc.), treatment may be longer (the total duration of continuous therapy should not exceed three to four months). Diosmin treatment courses are repeated after 2-3 months.

For the treatment of chronic lymphovenous insufficiency during the II and III trimester of pregnancy, the drug is used 1 tablet 1 time per day. The duration of therapy is not more than 30 days. It is necessary to stop taking the drug 2-3 weeks before birth.
With exacerbation of hemorrhoids

The drug Diosmin is used for 2-3 tablets per day with meals for 7 days. Further, if necessary, you can continue taking the drug 1 tablet 1 time per day for 1-2 months.
In case of microcirculation disorders

If one or more doses of the drug Diosmin is missed, it is necessary to continue using the drug in the usual mode and in the usual dose.
The drug is used 1 tablet per day in the morning on an empty stomach. The duration of therapy is usually 1-2 months.

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