Gelmindazol (Mebendazole) anthelmintic 100 mg 6 tablets

Composition Mebendazole/Helmindazole:

Active ingredient:
mebendazole (in terms of 100% substance) - 100.0 mg;
Excipients: corn starch - 72.0 mg,
colloidal silicon dioxide - 3.0 mg,
talc - 3.0 mg,
magnesium stearate - 3.0 mg,
crospovidone - 3.0 mg,
sodium lauryl sulfate - 0.5 mg,
lactose monohydrate - to obtain a tablet weighing 300.0 mg.

Pharmacodynamics Mebendazole/Helmindazole:

Anthelmintic drug with a wide spectrum of action; most effective against Enterobius vermicularis, Trichuris trichura, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Taenia solium, Echinococcus granulosus, Echinococcus multilocularis, Trichinella spiralis, Trichinella nativa. Causing an irreversible violation of glucose utilization, depletes glycogen stores in helminth tissues, interferes with the synthesis of cell tubulin, and also inhibits the synthesis of adenosine triphosphate (ATP).

Indications Helmindazole/Mebendazole:

Enterobiosis, ascariasis, hookworm infection, strongyloidosis, trichocephalosis, trichinosis, teniosis, both with mono-invasion and with mixed helminthiases; echinococcosis (if surgical treatment is not possible)

Pharmacokinetics Helmindazole/Mebendazole:

It is practically not absorbed in the intestines. After taking the drug at a dose of 100 mg twice a day for three consecutive days, the plasma concentration of mebendazole and its metabolite (2-amino derivative) does not exceed 0.03 μg / ml and 0.09 μg / ml, respectively.
Communication with plasma proteins - 90%. It is unevenly distributed over organs, accumulates in adipose tissue, liver, and helminth larvae. In the liver, it is metabolized to a 2-amino derivative that does not have anthelmintic activity. The half-life of 2.5-5.5 hours. More than 90% of the dose is removed through the intestine unchanged. The absorbed part (5-10%) is excreted by the kidneys.
helmindazole

Side effects Helmindazole/Mebendazole:

Allergic reactions: skin rash, urticaria, angioedema, Steven-Johnson syndrome, toxic epidermal necrolysis, exanthema, anaphylactic and anaphylactoid reactions. From the hemopoietic organs: neutropenia. From the digestive organs: nausea, vomiting, abdominal pain, diarrhea, increased activity of "liver" transaminases, alkaline phosphatase, hepatitis (when used in high doses for a long time).

From the nervous system: dizziness, headache, drowsiness, cramps. From the urinary system: hypercreatininemia, glomerulonephritis (when used in high doses for a long time).
Other: hair loss (when used in high doses for a long time).

Special conditions Helmindazole/Mebendazole:

The drug Mebendazole contains lactose, therefore, this drug is contraindicated in patients with rare hereditary lactose intolerance, lactase deficiency or impaired absorption of glucose / galactose. In patients with diabetes mellitus, it is necessary to control the concentration of glucose in the blood plasma. With prolonged use, it is necessary to control the picture of peripheral blood, liver and kidney function. During the day after administration, the use of ethanol, fatty foods, and the use of laxatives is prohibited. A periodic study of smears of the anal area and feces after the end of treatment is mandatory: therapy is considered effective in the absence of helminths or their eggs for the next 7 days. The results of a study of the development of Steven-Johnson syndrome and toxic epidermal necrolysis indicate a possible relationship between their occurrence and the simultaneous use of mebendazole and metronidazole. There is no other data documenting cases of such drug interactions. That is why the simultaneous use of mebendazole and metronidazole should be avoided. Effect on the ability to drive vehicles and mechanisms. Patients should be careful when driving vehicles and working with equipment, as during treatment dizziness and drowsiness may occur.

Contraindications Helmindazole/Mebendazole:

Hypersensitivity to mebendazole, other components of the drug,
ulcerative colitis, Crohn's disease,
liver failure,
children's age (up to 3 years),
pregnancy
lactation period,
lactose intolerance,
lactase deficiency,
glucose-galactose malabsorption,
simultaneous administration with metronidazole, phenytoin, carbamazepine, ritonavir.

Use during pregnancy and during breastfeeding Pregnancy.

The use of the drug during pregnancy is contraindicated. The period of breastfeeding. helmindazole

There is no evidence of whether mebendazole passes into breast milk. If it is necessary to use the drug during lactation, breastfeeding is recommended to be stopped.

Drug Interactions Helmindazole/Mebendazole:

Reduces the need for insulin in patients with diabetes. Do not use simultaneously with lipophilic substances. Cimetidine can increase the concentration in the blood, carbamazepine and other metabolic inducers - lower, and therefore the concentration of drugs in the blood serum should be monitored. The simultaneous use of mebendazole and metronidazole should be avoided.

Dosage Helmindazole/Mebendazole:

Inside with a little water. Adults and children over 3 years old. With enterobiosis - once at 100 mg / day (1 tablet); the course of treatment is 1 day. Since reinfection with enterobiasis is quite common, treatment should be repeated after 2 and 4 weeks. It is recommended to conduct simultaneous treatment of all family members. With ascariasis, trichocephalosis, hookworm and mixed helminthiases: 200 mg / day (1 tablet in the morning, 1 tablet in the evening); the course of treatment is 3 days.
With teniosis, strongyloidosis. Adults: 400 mg / day (2 tablets in the morning, 2 tablets in the evening); the course of treatment is 3 days. Children older than 3 years: 200 mg / day (1 tablet in the morning, 1 tablet in the evening); the course of treatment is 3 days. With echinococcosis. Adults and children over 14 years of age: in the first three days, 500 mg 2 times a day, in the next 3 days, the dose is increased to 500 mg 3 times a day; in the future, the dose is increased to 1000-1500 mg 3 times a day. The average duration of treatment for echinococcosis caused by Echinococcus granulosis is 4-6 weeks, caused by Echinococcus multilocularis - up to two years. With trichinosis on the 1st day, 3 times a day, 200-300 mg, on the 2nd day 4 times a day, 200-300 mg, and from 3 to 14 days - 3 times a day, 500 mg.

Overdose Helmindazole/Mebendazole:

Symptoms:
abdominal pain, nausea, vomiting, diarrhea. When used in high doses for a long time: reversible liver dysfunction, hepatitis, neutropenia. Treatment: it is necessary to remove the drug helmindazole from the stomach, causing vomiting or having washed the stomach, taking activated charcoal, symptomatic therapy.