Instructions for L-THYROXINE (Levothyroxine)
English product name
L-Thyroxin
Release form:
tab 50 mcg: 50 or 100 pcs
tab. 100 mcg: 20, 30, 40, 50, 60, 80, 100, 250, 300, 400, 500, 3000, 4000 or 5000 units
Description
Tablets 1 tab.
sodium levothyroxine 50μg
10 pcs - box-type contour (5) packages - cardboard packs.
10 pcs - box-type contouring packages (10) - cardboard packages.
50 pcs - packages of box contour (1) - cardboard packs.
ATC codes
H03AA01 Levothyroxine sodium
Clinical-pharmacological groups / Group affiliation
Thyroid hormone preparation
Active substance:
sodium levothyroxine
Pharmacotherapy group
Thyroid agent
Storage Conditions
List B.
The preparation should be stored in a dry, light-proof place at a temperature not higher than 25°C. Store in a place not accessible to children.
Best before date
Shelf life 3 years. Do not apply after expiry date.
· C73 Malignant thyroid gland regeneration.
· E01,1 Multi-nodule (endemic) goiter associated with iodine deficiency.
· E03 Other forms of hypothyroidism.
· E03.9 Hypothyroidism unspecified.
· E04.1 Non-toxic single-node goiter.
· E04.2 Non-toxic multi-nodular goiter.
· E05 Thyrotoxicosis [hyperthyroidism].
· E05.0 Thyrotoxicosis with diffuse goiter.
· E06,3 Autoimmune thyroiditis.
· E91* Diagnosis of endocrine disorders.
Component contraindications:
Levothyroxine sodium contraindications.
Hypersensitivity, untreated thyrotoxicosis, acute myocardial infarction, acute myocarditis, untreated adrenal cortex insufficiency (to be compensated before treatment).
Use of Levothyroxine sodium in breastfeeding.
During pregnancy and breastfeeding, treatment with sodium levothyroxine prescribed for hypothyroidism should continue. During pregnancy, an increase in the dose of the drug L-THYROXINE is required due to an increase in the level of thyroxine-binding globulin. The amount of thyroid hormone secreted with breast milk (even when treated with high doses of the drug L-THYROXINE) is not sufficient to cause any abnormalities in the baby when breastfeeding. Use in pregnancy in combination with thyrostatics is contraindicated, t; sodium levothyroxine may require an increase in thyroostatic doses. Because thyroostatics, unlike sodium levothyroxine, can penetrate the placenta, the fetus may develop hypothyroidism.
The FDA category of fetal activity. A.
During breastfeeding, the drug L-THYROXINE should be taken with caution, strictly in the recommended doses, under the supervision of a doctor.
Initial stage of replacement therapy for hypothyroidism
Patients without cardiovascular disease under 55 starting dose: women - 75-100 ug/day, men - 100-150 ug/day
Patients with cardiovascular disease or over 55 years of age The initial dose is 25 micrograms per day
increase by 25 μg at intervals of 2 months until the TCH in the blood is normalized
If symptoms of the cardiovascular system appear or worsen, correct the treatment of cardiovascular diseases
Recommended doses of levothyroxine for the treatment of congenital hypothyroidism
Age Daily dose of levothyroxine (ug) Levothyroxine dose per body mass (ug/kg)
0-6 months 25-50 10-15
6-12 months 50-75 6-8
1-5 years 75-100 5-6
6-12 years 100-150 4-5
≥12 years 100-200 2-3
Testimony Recommended doses (L-THYROXINE ug/day)
Euthyroid goiter treatment 75-200
Prevention of relapse after surgical treatment of euthyroid goiter 75-200
In complex therapy of thyrotoxicosis 50-100
Suppressive thyroid cancer therapy 150-300
Thyroid suppression test 4 weeks before test 3 weeks before test 2 weeks before test 1 week before the test
L-THYROXINE 75 ug/day 75 ug/day 150-200 ug/day 150-200 ug/day
For infants and children under 3 years of age, a daily dose of L-THYROXINE is given in one dose 30 minutes before the first feeding. The tablet is dissolved in water to a fine suspension, which is prepared immediately before the drug L-THYROXINE is taken.
Indications of the drug L-THYROXINE:
Hypothyroidism
euthyroid goiter
as replacement therapy and for the prevention of recurrence of goiter.
after thyroid resection
thyroid cancer (after different surgical treatment)
diffuse toxic goiter: after reaching the euthyroid state by thyrostatics (in the form of combined or monotherapy);
as a diagnostic tool for the test of thyroid suppression. component effects
Side effects of Levothyroxine sodium:
Tachycardia. Heart rate violation. Chest pain. Tremor. Worry. Insomnia. Hyperhidrosis. Reduced body weight. Diarrhea. Alopecia. Impaired adrenal function (with pituitary gland or hypothalamic hypothyroidism). Kidney function disorder in children. Allergic reactions (skin rash. Itchy skin).
