Vicks AntiGrip Complex
21120USD

Vicks AntiGrip Complex

SKU:911
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Formulation:Powder
Country of origin:United Kingdom
Expiration Date:Always fresh
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$11
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Instructions for Vicks AntiGrip

Release form Vicks AntiGrip:

Powder Vicks AntiGrip for preparation of oral solution from almost white to white with a yellowish or grayish tint, fine crystalline, free of large aggregates and inclusions, with a characteristic smell of lemon and menthol.
4.36 g - laminated sachets (5) - cardboard packs.

Structure Vicks AntiGrip:

1 pack.

  • paracetamol 500 mg
  • guaifenesin 200 mg
  • phenylephrine hydrochloride 10 mg
  • Excipients: sucrose - 2000 mg
  • citric acid - 330 mg
  • artaric acid - 330 mg
  • sodium cyclamate - 200 mg
  • sodium citrate - 500 mg
  • aspartame - 6 mg
  • ascorbic acid - 100 mg
  • potassium acesulfame - 17 mg
  • lemon flavor 8476 - 50 mg
  • lemon juice flavor - 120 mg
  •  menthol flavor - 100 mg
  • quinoline yellow dye - 1 mg.

Pharmaco-therapeutic group Vicks AntiGrip:

A remedy Vicks AntiGrip for eliminating the symptoms of acute respiratory infections and "colds" (analgesic non-narcotic drug + expectorant + alpha-adrenergic agonist).

Pharmacological properties Vicks AntiGrip:

Combined drug Vicks AntiGrip, the effect of which is due to the composition of its components.
Paracetamol has analgesic and antipyretic effects.
Guaifenesin has a mucolytic effect, facilitates the removal of phlegm from the bronchi and promotes the transition of an unproductive cough to a productive one.
Phenylephrine is a sympathomimetic, has a pronounced alpha-adrenergic activity, narrows the vessels of the nasal mucosa, eliminates swelling and hyperemia of the nasal mucosa.

Indications for use Vicks AntiGrip:

Symptoms of colds and flu (headache, sore throat, pain in the body and limbs
nasal congestion
cough with difficult discharge of viscous sputum, fever).

Mode of application Vicks AntiGrip:

Adults and children over 12 years old - appoint 1 sachet every 4-6 hours, but not more than 4 doses (sachets) / day. The maximum daily dose is 4 sachets.
The maximum duration of the drug use without consulting a doctor is no more than 5 days. If after 5 days of treatment there is no improvement or symptoms worsen, or new symptoms appear, the patient should consult a doctor.

Contraindications Vicks AntiGrip:

Liver dysfunction; severe chronic renal failure
arterial hypertension; hyperthyroidism
diabetes; phenylketonuria
IHD (acute myocardial infarction
atherosclerosis of the coronary arteries)
aortic stenosis
tachyarrhythmia
peptic ulcer of the stomach and duodenum in the acute stage
hyperplasia of the prostate
angle-closure glaucoma
porphyria
pheochromocytoma
Vicks AntiGrip
age up to 12 years; burden, lactation period; simultaneous administration of beta-blockers, tricyclic antidepressants, MAO inhibitors (including within 14 days after their cancellation); concomitant use of other sympathomimetic drugs; concomitant use of other drugs containing paracetamol; sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption syndrome; hypersensitivity to guaifenesin,

With caution: deficiency of glucose-6-phosphate dehydrogenase, blood diseases, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson, Rotor syndromes), hyperoxaluria, bronchial asthma, COPD, renal failure of mild to moderate severity, dehydration, hypovolemia, anorexia, bexia (insufficient supply of glutathione in the liver), viral hepatitis, alcoholic liver damage, alcoholism, Raynaud's syndrome; simultaneous use of cardiac glycosides, beta-blockers, methyldopa and other antihypertensive drugs, old age. Vicks AntiGrip

Side effects Vicks AntiGrip:

Paracetamol
Allergic reactions: rarely - urticaria, anaphylaxis, bronchospasm, angioedema.
Skin and subcutaneous tissue disorders: rarely - skin rash, frequency unknown - Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), acute generalized exanthematous pustulosis.
From the nervous system: rarely - dizziness.
From the side of the organ of vision: rarely - paresis of accommodation, increased intraocular pressure, mydriasis.
From the hematopoietic system: rarely - aplastic anemia, methemoglobinemia; very rarely - pathological changes in the blood, such as thrombocytopenia, agranulocytosis, hemolytic anemia, neutropenia, leukopenia, pancytopenia.
From the side of the cardiovascular system: rarely - increased blood pressure.
From the digestive system: rarely - nausea, vomiting, dry mouth, hepatotoxic effect.
From the urinary system: rarely - urinary retention, nephrotoxicity (papillary necrosis); frequency unknown - interstitial nephritis.

Phenylephrine
From the cardiovascular system: rarely - tachycardia, arterial hypertension, accompanied by headache, vomiting and heart palpitations.
From the nervous system: rarely - insomnia, nervousness, tremors, anxiety, agitation, confusion, irritability and headache.
From the digestive system: often - anorexia, nausea and vomiting.
Allergic reactions: rarely - skin rash, urticaria, anaphylaxis and bronchospasm. Vicks AntiGrip

Guaifenesin
From the nervous system: rarely - headache, dizziness and drowsiness.
From the digestive system: rarely - gastrointestinal discomfort, nausea, vomiting and diarrhea.

Special instructions Vicks AntiGrip:

It is recommended to take the drug Vicks AntiGrip in the shortest possible course and in the minimum effective dose necessary to eliminate symptoms.
Do not use the drug at the same time as other cough, cold remedies or drugs with decongestant action.
Simultaneous use of the drug Vicks AntiGrip with other paracetamol-containing drugs should be avoided, as this may cause an overdose of paracetamol.
In patients with alcoholic liver disease, the negative consequences of an overdose are more pronounced.
When using the drug for more than 5 days, the peripheral blood parameters and the functional state of the liver should be monitored.
The drug distorts the results of laboratory tests of the content of glucose and uric acid in the blood plasma.
It is recommended to take a sufficient amount of fluids during treatment.
Possibly pink urine.
Guaifenesin, which is part of the drug, can give false positive results in the determination of 5-hydroxyindoleacetic and vanillin mandelic acids in urine due to the effect of guaifenesin metabolites on color (guaifenesin should be discontinued 48 hours before urine collection for these tests).
The preparation contains sodium, which should be taken into account in patients on a diet with low sodium intake.
The drug contains aspartame, which is a source of phenylalanine, which can be toxic to patients with phenylketonuria.
During the use of the drug Vicks AntiGrip, you must refrain from taking alcohol and medications containing ethanol.
Effects on the ability to drive vehicles and use mechanisms
When driving vehicles and engaging in other potentially hazardous activities, it is necessary to take into account that the drug can cause side effects such as dizziness and confusion.

Drug interactions Vicks AntiGrip:

Paracetamol
Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication with a slight overdose.
Long-term use of barbiturates reduces the effectiveness of paracetamol.
Concomitant use with ethanol increases the risk of acute pancreatitis.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic effects.
When used together with NSAIDs, incl. salicylates, the nephrotoxic effect of paracetamol increases.
Diflunisal increases the plasma concentration of paracetamol by 50%, which increases the risk of developing hepatotoxicity.
Metoclopramide and domperidone may increase the rate of absorption of paracetamol.
Cholestyramine may reduce the rate of absorption of paracetamol.
Isoniazid reduces the clearance of paracetamol by suppressing its metabolic transformation in the liver, which can lead to an increase in the pharmacological effects of paracetamol and / or its toxicity. Vicks AntiGrip
Probenecid causes a decrease in the clearance of paracetamol by almost 2 times due to inhibition of the conjugation of paracetamol with glucuronic acid. When used simultaneously with probenecid, a reduction in the dose of paracetamol should be considered.
Regular use of paracetamol can lead to a possible decrease in zidovudine metabolism (increased risk of neutropenia).
Paracetamol can reduce the bioavailability of lamotrigine with a possible decrease in the severity of its effect due to the possible induction of metabolic transformation of lamotrigine in the liver. Vicks AntiGrip
Paracetamol enhances the effect of indirect anticoagulants, which increases the risk of bleeding and reduces the activity of uricosuric drugs.

Phenylephrine
Reduces the hypotensive effect of diuretics and antihypertensive drugs (including methyldopa, mecamylamine, guanadrel, guanethidine).
Phenothiazines, alpha-blockers (phentolamine), furosemide and other diuretics reduce the hypertensive effect.
MAO inhibitors (including furazolidone, procarbazine, selegiline), oxytocin, ergot alkaloids, tricyclic antidepressants, methylphenidate, adrenostimulants increase the pressor effect and arrhythmogenicity of phenylephrine.

Beta-blockers reduce the cardiac stimulating activity, against the background of reserpine, arterial hypertension is possible (due to the depletion of catecholamines in the adrenergic endings, the sensitivity to adrenergic agonists increases).
Inhalation anesthetics (including chloroform, enflurane, halothane, isoflurane, methoxyflurane) increase the risk of severe atrial and ventricular arrhythmias, since they sharply increase myocardial sensitivity to sympathomimetics.
Ergometrine, ergotamine, methylergometrine, oxytocin, doxapram increase the severity of the vasoconstrictor effect. Vicks AntiGrip

Reduces the antianginal effect of nitrates, which in turn can reduce the pressor effect of sympathomimetics and the risk of arterial hypotension (simultaneous use is allowed depending on the achievement of the desired therapeutic effect).
Thyroid hormones increase (mutually) the effect and the associated risk of coronary insufficiency (especially in coronary atherosclerosis).
The simultaneous use of phenylephrine and other sympathomimetic amines can lead to an increase in blood pressure and other side effects from the cardiovascular system.
The concomitant use of cardiac glycosides (eg, digoxin) and phenylephrine may increase the risk of arrhythmias and myocardial infarction.

Guaifenesin
Codeine makes it difficult to pass liquefied sputum.
Compatible with bronchodilators, antimicrobial drugs, cardiac glycosides.

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