Instructions for Argosulfan (Sulfadiazine silver) cream
Argosulfan cream is an antibacterial preparation for topical use, which promotes the healing of wounds (burns, trophic, purulent, etc.), provides effective protection of wounds from infection, relieves pain and burning sensation in the wound, shortens the treatment time and the preparation time of the wound for skin transplantation, in many cases leads to an improvement in the condition, eliminating the need for transplantation.
Sulfanilamide - sulfathiazole, which is part of the cream, has a wide spectrum of antibacterial bacteriostatic action against gram-positive and gram-negative bacteria. The mechanism of the antimicrobial action of sulfathiazole - inhibition of the growth and reproduction of microbes - is associated with competitive antagonism with PABA and inhibition of dihydropteroate synthetase, which leads to a disruption in the synthesis of dihydrofolic acid and, ultimately, its active metabolite, tetrahydrofolic acid, which is necessary for the synthesis of purines, microbes, and pyrimic acid. The silver ions present in the preparation increase the antibacterial effect of sulfonamide by several tens of times - they inhibit the growth and division of bacteria by binding to the DNA of a microbial cell. In addition, silver ions weaken the sensitizing properties of sulfanilamide.
Due to the hydrophilic base of the cream, which has an optimal pH and contains a large amount of water, it provides an analgesic effect and moisturizes the wound, contributing to good tolerance, facilitating and accelerating wound healing.
Argosulfan Pharmacokinetics:
The silver salt of sulfathiazole contained in the preparation has a low solubility, as a result of which, after topical application, the concentration of the drug in the wound is maintained at the same level for a long time. Due to the minimal resorption of the drug, it has no toxic effect. Only a small amount of the silver salt of sulfathiazole enters the bloodstream, after which it undergoes acetylation in the liver.
In urine it is in the form of inactive metabolites and partially unchanged. The absorption of sulfathiazole increases after the drug is applied to extensive wound surfaces.
Argosulfan Indications for use:
- The drug Argosulfan is used to treat patients with skin lesions of various etiologies,
- including
- Burns of any degree of various origins.
- Frostbite.
- Trophic ulcers of the extremities of various origins, bedsores, purulent wounds, simple contact dermatitis.
- Cuts, abrasions and other household injuries
- Infectious skin diseases, including infected dermatitis, microbial eczema, streptoderma, staphyloderma.
Argosulfan Mode of application:
Preparation Argosulfan for external use. The drug can be applied both on open skin and under an occlusive dressing. Before applying the cream, you should cleanse the affected area of the skin. The drug is applied under sterile conditions. In case of skin lesions, which are accompanied by the formation of exudate, before using the drug, the affected skin area is treated with a 0.1% chlorhexidine solution or 3% aqueous boric acid solution. The cream should be applied in a 2-3 mm layer on the affected skin area until the tissues are completely healed or until the wound surface is ready for skin grafting.