Instructions for Allergodil (Azelastine)
description:
Trade name: Allergodil International generic name: Azelastin Medicinal Form:
Eye Drops Description:
Colorless, Transparent or Almost Transparent Solution.
Pharmacotherapy group:
Anti-allergic agent - H1-histamine receptor blocker.
Acting substances:
Azelastin
Release form:
drops
composition:
In 1 bottle contains:
Ingredients Solution volume in the vial 6 ml 10 ml
Active substance:
Azestatin hydrochloride 3,000 mg 5,000 mg
Auxiliary substances: Gipromellosis 6,000 mg 10,000 mg
Dynatrya edetate 3,00 0 mg 5,000 mg
Benzalconia chloride 0.750 mg 1,250 mg Sorbitol 399,996 mg 666,660 mg
Sodium hydroxide to pH 6.0 to pH 6.0
Water for injections Up to 6 ml (6 ml (6 , 090 g) Up to 10 ml (10,150 g)
Pharmacological effect:
Azelastin, a derivative of phthalazinone, is a strong long-acting anti-allergic agent that selectively blocks H1 receptors. When applied to the mucous eye, there are additional anti-inflammatory and membrane-stabilizing effects of azelastin: azelastin inhibits the release of mediators of early and late phase allergic reactions, for example, leukotriene, histamine, platelet activation factor, reduces the number of ICAM-1 (molecule of intercellular adhesion 1) and eosinophil cells. Clinically significant effects on qt (zTc) interval have not been detected even with long-term use of high doses of azelastin.
pharmacokinetics:
When reused, Allergodil in the form of eye drops (1 drop in each eye 4 times/day) Cmax were very low and detected at or below the measurement limit.
Testimony:
- prevention and treatment of seasonal allergic conjunctivitis,
- treatment of unseasonal (year-round) allergic conjunctivitis
contraindications:
The incidence of side effects is as follows: Very often: > 1/10, Often: <1/10 > 1/100, Infrequent: <1/100 > 1/1000, Rarely: <1/1000> 1/10000, Very rare: <1/10000. Local: often - transient blurred vision, conjunctivitis, rarely - a burning sensation in the eye.
Common: infrequently - a feeling of bitterness in the mouth, very rarely - allergic reactions, headache, asthma, dyspnoe, fatigue, flu-like symptoms, pharyngitis, itching, rhinitis.
Precautions
Contradictions:
children under 4 years old.
Use in pregnancy and breast-feeding
Allergodil in the form of eye drops is not recommended to be used in the first trimester of pregnancy, as well as during lactation.
In experimental studies, no data on the teratogenic action of azelastin was obtained when used in doses many times greater than the therapeutic range.
How to use and dose:
Seasonal allergic conjunctivitis: in the absence of other doctor's recommendations, adults and children from 4 years of age bury twice a day (morning and evening) 1 drop in each eye. If necessary, the dose is increased to 4 times a day one drop in each eye. The drug Allergodil is used until the symptoms disappear, but not more than 6 weeks. In the case of suspected exposure to the allergen, the drug Azelastine is used for a preventive purpose. Unseasonal (year-round) allergic conjunctivitis: in the absence of other doctor's recommendations, adults and children from 4 years of age bury twice a day (morning and evening) 1 drop in each eye. If necessary, the dose is increased to 4-x once a day one drop in each eye. The duration of use is no more than 6 weeks.
Side effects:
From the organ of vision: increased sensitivity of the eye, sensation of foreign body, color change of the conjunctival membrane, irritation, soreness, itching, redness, swelling, increased tearing, rarely - dry eyes, bleprite.
Systemic reactions: dysponea, dysgeusia, dry skin.
overdose:
Data on drug Allergodil overdose Allergodil are missing.
Interaction with other drugs Allergodil
Drug interaction of the drug Allergodil not revealed.
