Instructions for Allergodil (Azelastine) nasal spray 10 ml
Allergies are more common at the age of 10-20 years. This problem is faced by 8-12% of the world's population. In response to the exposure of external stimuli there is an allergic runny nose, which disrupts breathing, interferes with sleep and just causes discomfort. To remove such a reaction of the body will help drops. Their action is effective because it is aimed at the center of pathology.
Treatment of allergic runny nose For rapid treatment you need to identify and eliminate the irritant. The therapy is complex, includes nutrition correction and environmental control.
Release form, composition and packaging
Nasal dosed spray:
1 dose of Azelastine hydrochloride 140 micrograms.
Auxiliary substances: EDTA EDTA dynatious salt x 2H2O, hydroxypropylethyl cellulose, citric acid, sodium phosphate two-core twelve-year-old, sodium chloride, purified water.
Clinical and pharmacological group: Anti-allergic drug Allergodil for local use in ENT practice.
Blocker histamine H1 receptor, a derivative of phthalazinone. It has a strong and long-lasting anti-allergic effect. Inhibits the synthesis or release of mediators involved in the early and late stages of allergic reactions (including leukotrien, serotonin, platelet activation factor /PAF/), inhibits the release of histamine from mast cells activated by the allergen, prevents bronchospasm caused by leukotriene and PAF, reduces the number of molecular cells.
With long-term use in high doses, there was no clinically significant effect of Azelastine on the interval of qT.
pharmacokinetics:
Suction and distribution
hours after intranasal use in the daily dose of 560 micrograms, the concentration of Azelastine in blood plasma is about 0.65 ng/ml; In the daily dose of 1.12 mg - 1.09 ng/ml. Thus, the concentration of Azelastine in blood plasma is proportional to the dose of the drug Allergodil. Despite the increase in the dose, systemic bioavasiness after intranasal use is about 8 times lower than with oral intake of Azelastine in the daily dose of 4.4 mg (therapeutic dose in the treatment of allergic rhinitis).
After repeated intranasal administration of the drug Allergodil in a daily dose of 560 micrograms of Css Azelastine in blood plasma is in healthy volunteers about 0.27 ng/ml.
Reuse of the drug Allergodil in patients with allergic rhinitis leads to an increase in the concentration of Azelastine in plasma compared to healthy volunteers, which allows to make an assumption of more pronounced systemic absorption (most likely due to increased permeability through the inflamed mucosaic of the nasal cavity).
metabolism
The concentration of active metabolite N-dismethylacelase is at the lower limit of the definition of quantitative content or does not reach it (0.12 ng/ml).
Testimony:
- seasonal
- year-round rhinitis
- rhinoconjunctivitis.
Dosage:
Allergodil is injected at one dose (140 micrograms/0.14 ml) into each nostril 2 times/day, which corresponds to a daily dose of Azelastine 560 micrograms. Allergodil is used before the symptoms disappear. Possible long-term use, but not more than 6 months.
Rules of use of the drug Allergodil
1. Remove the protective cap.
2. Before first use, click on the sprayer 2-3 times.
3. Inject one at once into each nostril, while holding your head straight.
4. Put on the protective cap again.
overdose:
So far, cases of drug Allergodil overdose Allergodil have not been reported.
Medicinal interaction:
Drug interaction of the drug Allergodil has not been revealed.
Terms and conditions
The drug Allergodil in the form of a nasal spray should not be stored at a temperature below 8 degrees C.
After opening the bottle, the spray should be used for no more than 6 months.
