Ambrobene Stoptussin (guaifenesin, butamirate)

Instructions for Ambrobene Stoptussin (guaifenesin, butamirate)

English product name
Ambrobene STOPTUSSIN

Release form
Pills

Description Ambrobene Stoptussin

Tablets are white or almost white, round, flat-cylindrical, with a chamfer and a dividing line.

1 tab.
butamirate citrate 4 mg
guaifenesin 100 mg
Excipients: silicon dioxide - 1 mg, mannitol - 60 mg, microcrystalline cellulose (PH 200) - 60 mg, glyceryl behenate - 1 mg, magnesium stearate - 4 mg.

10 pieces. - blisters (2) - cardboard packs with first opening control.

ATX codes
R05FB02 Antitussives in combination with expectorants

Clinical and pharmacological groups / Group affiliation
Antitussive and expectorant drug

Active substance Ambrobene Stoptussin

• guaifenesin
• butamirate dihydrogen citrate

Pharmacotherapeutic group Ambrobene Stoptussin

Expectorant + antitussive 

Storage conditions
The drug should be stored out of the reach of children, protected from light at a temperature not exceeding 25°C.

pharmachologic effect Ambrobene Stoptussin

The combined drug has a mucolytic (expectorant) and antitussive effect. Butamirate dihydrogen citrate exhibits a peripheral local anesthetic effect on the sensitive nerve endings of the bronchial mucosa, which provides an antitussive effect. Guaifenesin stimulates the production of secretions from the bronchial glands and reduces the viscosity of mucus. Increased secretion occurs both due to a direct effect on the bronchial glands - stimulation of secretion from them and removal of acidic glycoproteins from acinar cells, and due to a reflex mechanism when the afferent parasympathetic fibers of the gastric mucosa are irritated and the respiratory center is suppressed. Increased tone of the bronchial nerve vagus promotes the secretion of bronchial secretions. The mucus produced by the bronchial glands activates the work of the ciliated epithelium, which greatly facilitates the removal of mucus from the bronchi and its expectoration.

Indications Ambrobene Stoptussin

• The drug is intended for the treatment of dry irritating cough,
• including cases associated with infectious and inflammatory processes in the upper and lower respiratory tract.

Directions for use, course and dosage Ambrobene Stoptussin

The drug should be taken orally after meals. The tablets should be swallowed with liquid such as water, tea or fruit juice.

Adults and children over twelve years of age are prescribed the drug depending on their body weight:

- Body weight less than 50 kg: 0.5 tablets 4 times a day.
- Body weight from 50 to 70 kg: 1 tablet 3 times a day.
- Body weight from 70 to 90 kg: 1.5 tablets 3 times a day.
- Body weight over 90 kg: 1.5 tablets 4 times a day.

The interval between doses of the drug is from 4 to 6 hours.

The text has been redone while maintaining the basic meaning.

• Nosology (ICD codes)
• J04
• Acute laryngitis and tracheitis
• J06.9
• Acute upper respiratory tract infection, unspecified
• J20
• Acute bronchitis
• R05
• Cough