Instructions for Amixin
Composition Amixin:
tiloron (tilaxin) 125 mg Excipients: potato starch, microcrystalline cellulose, povidone (collidone 30), calcium stearate, croscarmellose sodium (primellose). Shell composition: hypromellose (hydroxypropyl methylcellulose), titanium dioxide, macrogol 4000 (polyethylene glycol 4000), polysorbate 80 (tween 80), quinoline yellow (E104), yellow-orange 85 (E110).
Pharmacodynamics Amixin:
A low molecular weight synthetic inducer of interferon that stimulates the formation of alpha, beta, gamma interferons in the body. The main structures producing interferon in response to the introduction of tilorone are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After taking the drug inside, the maximum production of interferon is determined in the sequence of the intestine-liver-blood after 4-24 hours. Amixin has an immunomodulating and antiviral effect. In human leukocytes induces the synthesis of interferon. Stimulates bone marrow stem cells, depending on the dose, enhances antibody formation, reduces the degree of immunosuppression, restores the ratio of T-suppressors and T-helpers.
Effective in various viral infections (including those caused by influenza viruses, other pathogens of acute respiratory viral infections, hepatitis viruses, herpes viruses). The antiviral action mechanism is associated with inhibition of the translation of virus-specific proteins in infected cells, as a result of which reproduction of viruses is suppressed.
Pharmacokinetics Amixin:
Absorption After taking the drug inside, tilorone is rapidly absorbed from the digestive tract. Bioavailability is about 60%.
Distribution Binding to plasma proteins is about 80%. Metabolism and excretion Tiloron is not biotransformed and does not accumulate in the body. It is excreted almost unchanged with feces (about 70%) and urine (about 9%). T1 / 2 is 48 hours.
Side effects Amixin:
From the digestive system: symptoms of dyspepsia are possible. Other: short-term chills, allergic reactions are possible.
Features of the sale Amixin:
Over-the-counter
Special conditions Amixin:
Amixin is compatible with antibiotics and traditional treatment for viral and bacterial infections.
Indications Amixin:
In adults
- for the prevention and treatment of influenza and SARS
- for the treatment of viral hepatitis A, B and C
- for the therapy of herpes infection
- for the therapy of cytomegalovirus infection
- as part of the complex therapy of allergic and viral encephalomyelitis (including multiple sclerosis, leukoencephalitis, uveoencephalitis)
- as part of complex therapy of urogenital and respiratory chlamydia
- as part of the complex therapy of pulmonary tuberculosis
- In children older than 7 years
- for the therapy of influenza and SARS
Contraindications Amixin:
- pregnancy;
- period of breastfeeding;
- children's age up to 7 years;
- Hypersensitivity to the drug.
Drug Interactions Amixin:
No clinically significant drug interaction of Amixin with antibiotics and conventional treatment of viral and bacterial infections has been identified.
Dosage Amixin:
Amixin is taken orally after a meal. For children older than 7 years: For uncomplicated forms of influenza and other acute respiratory viral infections - 60 mg once a day on the 1st, 2nd and 4th day from the start of therapy. The course dose is 180 mg (3 tablets).
In case of complications of influenza or other acute respiratory viral infections - 60 mg once a day on the 1st, 2nd, 4th and 6th day from the start of treatment. The course dose is 240 mg (4 tablets). For adults (over 18 years old):
For the therapy of influenza and other acute respiratory viral infections - 125 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. On a course - 750 mg (6 tablets).
For the prevention of influenza and other acute respiratory viral infections - 125 mg once a week for 6 weeks. On a course - 750 mg (6 tablets). For the treatment of herpetic, cytomegalovirus infection - the first two days at 125 mg, then after 48 hours at 125 mg. The course dose is 1.25-2.5 g (10-20 tablets). For non-specific prophylaxis of viral hepatitis A - 125 mg once a week for 6 weeks.
For the treatment of viral hepatitis A - on the first day, 125 mg 2 times, then 125 mg after 48 hours. 1.25 g (10 tablets) per course. For the treatment of acute hepatitis B, the first two days are 125 mg, then 125 mg after 48 hours, 2 g (16 tablets) per course of treatment. With a prolonged course of hepatitis B - 125 mg 2 times a day on the first day, then 125 mg after 48 hours. The course of treatment is 2.5 g (20 tablets).
In chronic hepatitis B, the initial phase of therapy (2.5 g - 20 tablets) is the first two days, 125 mg 2 times a day, then 125 mg after 48 hours. Continuation phase (from 1.25 g - 10 tablets to 2.5 g - 20 tablets) - 125 mg per week.
The course dose of Amixin is from 3.75 g to 5 g, the duration of therapy is 3.5-6 months, depending on the results of biochemical, immunological, morphological studies, reflecting the degree of activity of the process. In acute hepatitis C - 125 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. The course of therapy Amixin is 2.5 g (20 tablets).
In chronic hepatitis C, the initial phase of treatment (2.5 g - 20 tablets) is the first two days, 125 mg 2 times a day, then 125 mg after 48 hours. Continuation phase (2.5 g - 20 tablets) - 125 mg per week. The course dose of Amixin is 5 g, the duration of therapy is 6 months, depending on the results of biochemical, immunological, morphological markers of the activity of the process.
In the complex treatment of neuroviral infections - 125-250 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. The dose is set individually, the course of treatment is 3-4 weeks.
With urogenital and respiratory chlamydia - the first two days at 125 mg, then after 48 hours at 125 mg. The course dose is 1.25 g (10 tablets). With the complex therapy of pulmonary tuberculosis - 250 mg for the first two days of therapy, then 125 mg after 48 hours. The course dose is 2.5 g (20 tablets).
Overdose Amixin:
To date, cases of overdose of Amixin are unknown.
