Instructions for Aquadetrim (Cholecalciferol) tablets soluble
Description Aquadetrim:
Round flat cylindrical tablets from white to white with a yellowish color, with a bevy and a risk.
Active substances
Colecalciferol
Release form
Tablets
Composition
1 tablet contains:
active substance Aquadetrim:
vitamin D3 100 SD/S Ph dry - ten mg / twenty mg (corresponds to 1000 IU / 2000 IU of colecalciferol) [active substance: colecalciferol (vitamin D3 crystalline);
auxiliary substances:
modified starch,
sucrose, ascorbat crystalline sodium, medium-chain triglycerides, silicon dioxide, d,l-alpha-tocopherol];
auxiliary substances:
mannitol,
sodium benzoate.
Testimony Aquadetrim:
- Treatment of rickets.
- Complex treatment of osteoporosis,
- including postmenopausal.
Contraindications Aquadetrim:
Increased sensitivity to drug components. Hypervitaminosis D, increased concentration of calcium in the blood (hypercalciemia), increased release of calcium with urine (hypercalciuria), urolithiasis (formation of calcium oxalate stones), sarcoidosis, acute and chronic liver and kidney diseases, renal failure, active form of pulmonary tuberculosis, pseudohypoparathyroidism, deficiency of saccharase / isomalthase, intolerance of fructose, glucose-galactotic malabsorption.
Method of use and doses Aquadetrim:
Dissolve the tablet in room temperature water (quantity of water not less than 15 ml - one tablespoon). Dissolving the pill takes some time (about one - two minutes).
Pharmacological effect Aquadetrim:
Vitamin D3 is a natural form of vitamin D Akvadetrim that is produced in the skin by the sun. Compared to vitamin D2, it is 25% more active.
Vitamin D Akvadetrim binds to a specific vitamin D receptor (VDR) that regulates the expression of many genes, including genes in the ion channel TRPV6 (which absorbs calcium in the gut), CALB1 (a calbindin; provides calcium transport to the blood stream), BGLAP (osteocalcin; provides bone mineralization and calcium homeostasis), SPP1 (osteopontin; regulates osteoclasts migration), REN (renin; It regulates blood pressure, being a key element of renin-angiotensin-aldosterone regulation system), IGFBP (binding protein of insulin-like growth factor;
Enhances insulin-like growth factor), FGF23 and FGFR23 (fibroblast growth factor 23); regulate calcium levels, phosphate anion, fibroblast cell division processes), TGFB1 (transforming growth factor beta-1; regulates cell division and differentiation of osteocytes, chondrocytes, fibroblasts, and keratinocytes), LRP2 (LDL-receptor-bound protein 2; mediating low-density lipoprotein endocytosis), INSR (insulin receptor; provides insulin effects on any cell type).
