Instructions for Arbidol
Composition Arbidol:
Umifenovir (Umifenovir hydrochloride monohydrate (Arbidol) in terms of Umifenovir hydrochloride) - 50 mg Excipients: potato starch, microcrystalline cellulose, colloidal silicon dioxide (Aerosil), povidone (25 Collidone), calcium stearate.
Pharmacodynamics Arbidol:
Antiviral agent Umifenovir. Specifically inhibits influenza A and B viruses, associated with severe acute respiratory syndrome (SARS). According to the mechanism of antiviral action, it belongs to fusion (fusion) inhibitors, interacts with the hemagglutinin of the virus and prevents the fusion of the lipid membrane of the virus and cell membranes.
It has a moderate immunomodulatory effect. It has interferon-inducing activity, stimulates humoral and cellular immunity reactions, macrophage phagocytic function, increases the body's resistance to viral infections.
It reduces the incidence of complications associated with a viral infection, as well as exacerbations of chronic bacterial diseases. Therapeutic efficacy in viral infections is manifested in a decrease in the severity of general intoxication and clinical phenomena, and a reduction in the duration of the disease.
Refers to low-toxic drugs (LD50> 4 g / kg). It does not have any negative effects on the human body when administered orally in recommended doses. medicine for Covid
Pharmacokinetics Arbidol:
It is rapidly absorbed and distributed to organs and tissues. The maximum concentration in blood plasma when taken at a dose of 50 mg is reached after 1.2 hours, at a dose of 100 mg - after 1.5 hours. It is metabolized in the liver.
The elimination half-life is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in a small amount by the kidneys (0.12%). During the first day, 90% of the administered dose is excreted. Side effects Rarely - allergic reactions. Umifenovir
Features of the sale Arbidol:
Over-the-counter
Special conditions Does not show central neurotropic activity and can be used in medical practice as a preventive measure in healthy individuals of various professions, including requiring increased attention and coordination of movements (drivers of transport, operators, etc.).
Indications Arbidol:
Prevention and treatment in adults and children: - influenza A and B, acute respiratory viral infections, severe acute respiratory syndrome (SARS) Covid 19 (including those complicated by bronchitis, pneumonia); - secondary immunodeficiency states; - complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infection.
Prevention of postoperative infectious complications and normalization of immune status.
Combined therapy of acute intestinal infections of rotavirus etiology in children older than 3 years.
Contraindications Arbidol:
Hypersensitivity to the drug Umifenovir, age up to 3 years.
Drug interaction Umifenovir:
When prescribed with other drugs, no negative effects were noted.
Dosage Arbidol:
Inside, before eating. Single dose: for children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg (2 capsules of 100 mg or 4 capsules of 50 mg). For non-specific prophylaxis:
In direct contact with patients with influenza and other acute respiratory viral infections: - Children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg once a day for 10-14 days.
During the period of the epidemic of influenza and other acute respiratory viral infections, to prevent exacerbations of chronic bronchitis, relapse of herpetic infection: - for children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg twice a week for 3 weeks. Umifenovir
Arbidol for the prevention of SARS, Covid, (in contact with the patient): - Adults and children over 12 years of age are prescribed 200 mg Arbidol once a day. Children from 6 to 12 years of age, 100 mg once a day (before meals) for 12-14 days.
Prevention of postoperative complications: - for children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 2 days before surgery, then on 2 and 5 days after surgery. For treatment: Influenza, other acute respiratory viral infections without complications: - for children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg Arbidol 4 times a day (every 6 hours) for 5 days.
Influenza, other acute respiratory viral infections with the development of complications (bronchitis, pneumonia, etc.): - for children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 4 times a day (every 6 hours) for 5 days, then a single dose 1 time per week for 4 weeks.
Severe acute respiratory syndrome (SARS): - for children over 12 years of age and adults - 200 mg 2 times a day for 8-10 days. In the complex treatment of chronic bronchitis, herpetic infection: - for children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults
- 200 mg 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week for 4 weeks. Complex therapy of acute intestinal infections of rotavirus etiology in children older than 3 years: - from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, older than 12 years old - 200 mg 4 times a day (every 6 hours) for 5 days.
Arbidol (Umifenovir) antiviral agent
