Instructions for Drotaverine Teva 20 pills 40 mg
Drotaverine Teva 20 pills 40 mg
Current substances
Drotaverin
Release Form:
Pills
Composition:
1 tablet contains:active substance of dartaverine hydrochloride 40.00 mg;auxiliary substances: lactose monohydrate 67.00 mg; Pvidon-K25 4.00 mg; cellulose microcrystalline 21.00 mg; Sodium cross-carmellosis 5.00 mg; Magnesium Stearat 3.00 mg.
Pharmaceutical effect
Drotaverin is a derivative of isochinolin which manifests spasprama action on smooth musculature by inhibiting the enzyme of phosphodiesterase 4 (FDE-4). Inflexing of enzyme FDE-4 leads to increased concentration of cyclic adenosinmonophosphate (CAMF), which inactivates the mild chain of myozine kinase (MLCK), which in turn leads to relaxation of smooth sculpture.
Drotaverin inhibits the enzyme FDE-4 in vitro without inhibiting the isoferments FDE-3 and FDE-5. FDE-4 appears to be functionally very important for reducing the reducing capacity of smooth muscles, so FDE-4 selective inhibitors can be effective in treating hyperkinetic diseases and spastic-related diseases of the gastrointestinal tract The enzyme hydrolysis of zAMF in smooth muscle cells of myocardium and vessels is mainly an isoferment of FDE-3, which explains the high efficiency of the drotaverin as spasprayer in the absence of a pronounced action on the cardiovascular system and serious cardiovascular undesirable reactions.Drotaverin is effective in the spasms of smooth musculature both nervous and muscle etiology. Regardless of the type of vegetative innervation, dartaverine acts on the smooth musculature of the LCT, the bile-producing tract, as well as the urinary and vascular systems. Due to the vasodilating action, the dartaverine improves blood supply to the tissues.
Pharmacokinetics:
Intake and distribution. When inward and parenterally administered, the drotaverine is rapidly and completely absorbed. The maximum concentration in plasma (Smach) is achieved within 45-60 minutes. Linked to plasma proteins (alpha-albumin, alpha- and beta-globulin
Indications:
- Smooth musculature spasms associated with liver and bile tract diseases
- bile-stone disease
- cholecystitis
- pericolecystitis
- holangite
- papillite
- spasms of smooth musculature of the urinary system
- urinary disease,
- pielitis,
- cystitis,
- bladder tenezms.
- As a auxiliary therapy:- spasms of smooth musculature LCT
- ulcerous stomach disease and duodenal intestine
- gastritis, cardia and gatekeeper spasms
- enteritis
- colitis
- accompanied by constipation and meteorism
- tensor headache
- dismenore
Contraindications:
Increased sensitivity to drotaverine or any of the components of the drug Drotaverine;
severe kidney failure; Severe liver failure (Class C on the Child-Pew scale); severe heart failure (low-heart-emitting syndrome);
Children up to 6 years of age; Breastfeeding period; lactose intolerability, lactase deficit, glucose-galactic malabsorption syndrome.
Use in pregnancy and breastfeeding
Precautionary is used with care during pregnancy and lactation (breastfeeding).
Method of application and dose:
The recommended daily dose for adults is 120-240 mg (in 2-3 doses). For children aged 6-12, the maximum daily dose is 80 mg divided by 2 doses; For children over 12 years of age, the maximum daily dose is 160 mg divided by 2-4 doses.Recommended duration of treatment without a doctor's consultation is 1-2 days.
Side effects:
Precautions
Overdose:
Interaction with other drugs Drotaverine
Special instructions:
During treatment, it is necessary to refrain from driving motor vehicles and engaging in potentially dangerous activities, which require increased concentration and rapid psychomotor reactions.
Overdose:
There is no data on overdose with the drug Drotaverin-Teva.
Symptoms of overdosage can be arrhythmia of the heart and impairment of conductivity (including complete blockage of the legs of the Gis beam), cardiac arrest, up to the death outcome.
Treatment: stomach washing, symptomatic therapy.
