Instructions for Galavit (Aminodihydrophtalazinedione sodium)
Pharmacological properties Galavit:
Galavit (5-amino-1,2,3,4 tetrahydrophthalazine-1,4-dione sodium salt) has anti-inflammatory and immunomodulatory properties. Its main properties are due to the ability to influence the functional and metabolic activity of macrophages.
In inflammatory processes, the drug Galavit reversibly inhibits for 6-8 hours the excessive synthesis of tumor necrosis factor, interleukin-1, reactive oxygen species by hyperactive macrophages, which predetermine the degree of activity of inflammatory reactions, their cyclicity, as well as the severity of intoxication. Normalization of the functional state of macrophages leads to a decrease in autoaggression and restoration of the function of T-lymphocytes.
At the same time, the drug stimulates the microbicidal system of neutrophilic granulocytes, accelerates phagocytosis and increases the body's nonspecific resistance to infectious diseases. The main pharmacological effects of the drug Galavit last for 72 hours.
Pharmacokinetics Galavit:
Galavit is excreted mainly by the kidneys. After i / m injection, the half-life is 15-30 minutes, after rectal administration - 60-70 minutes.
Indications Galavit:
Assigned to adults as an immunomodulator as part of complex therapy:
• in acute and chronic diseases of the gastrointestinal tract, accompanied by intoxication and / or diarrhea (acute intestinal infections, stomach and duodenal ulcers, ulcerative colitis, Crohn's disease, liver damage of various etiologies, including viral hepatitis B and C, gastroenteritis);
• in acute infectious diseases (intestinal infections, purulent meningitis);
• bronchitis, pneumonia, septic conditions, post-traumatic osteomyelitis, erysipelas;
• for diseases of the genitourinary tract (genital herpes, cytomegalovirus infection, chlamydia, mycoplasmosis, uterine myoma, benign prostatic hyperplasia);
• for purulent-septic processes in the pre- and postoperative period and for the prevention of infectious surgical complications;
• with chronic recurrent herpes infection;
• with chronic recurrent furunculosis;
• in chronic inflammatory diseases that developed against the background of secondary immunodeficiency;
• for immunocorrection and immunological rehabilitation in oncological diseases, such as stage III disseminated breast cancer, stage III lung cancer (as part of complex chemotherapy and radiation therapy).
Application Galavit:
Galavit for injection
Enter in / m. Before use, the drug is diluted in 2 ml of water for injection or 0.9% sodium chloride solution . The dose and duration of the drug depends on the nature and severity of the disease.
In acute intestinal infections (salmonellosis, dysentery, food poisoning) and other diseases accompanied by diarrhea , the initial dose for adults is 200 mg. Then the drug is administered in a dose of 100 mg 2-3 times a day until the symptoms of intoxication disappear. In the acute period of the disease, as a rule, 2-3 injections are sufficient.
In infectious diseases of different e tiologii (including septic conditions, hepatitis, meningitis) initial adult dose - 200 mg. Then they switch to the introduction of the drug at a dose of 100 mg 2-3 times a day until the symptoms of intoxication and inflammation disappear, then it is possible to continue the course of therapy at a dose of 100 mg 1 time in 2-3 days.
The duration of the course depends on the patient's condition and can be up to 25 injections.
In diseases of the gastrointestinal tract (gastric ulcer and duodenal ulcer, ulcerative colitis, Crohn's disease ) and the genitourinary system, the initial dose for adults in the acute period is 200 mg once a day for 1-2 days, then they switch to the administration of the drug, 100 mg 1 every 2-3 days. The course of treatment is 15–25 injections, depending on the course of the disease.
With uterine myoma , 100 mg / day is prescribed daily for 5 days, then - 5 injections of 100 mg every other day, then - 100 mg 1 time in 2-3 days. The course of treatment is 15–20 injections.
With benign prostatic hyperplasia in adults, it is prescribed daily at 100 mg / day for 5 days, then 100 mg 1 time in 2-3 days.
For purulent-septic processes in the pre- and postoperative period, as well as for the prevention of postoperative infectious complications in adults, 100 mg of the drug is prescribed before or after surgery 1 time per day for 5 days, then 5 injections of 100 mg every other day, further - 100 mg after 72 hours; the course of treatment is 15 injections.
In chronic recurrent furunculosis in adults, 100 mg of the drug Galavit is prescribed daily for 5 days, then 15 injections of 100 mg every other day. The course of treatment is 20 injections.
In chronic recurrent herpes infection (as part of complex therapy), 100 mg / day is prescribed every other day (15-20 injections) or 100 mg / day every day for 10 days, then - 100 mg every other day (15 injections). The course of treatment is 20 injections.
In chronic inflammatory diseases that have developed against the background of an immunodeficiency state, adults are prescribed 100 mg 1 time in 3 days or 100 mg daily for 5 days, then - 1 time in 2-3 days. The course Galavit of treatment is 20 injections.
For immunocorrection in cancer: stage III breast cancer, stage III lung cancer (in combination with chemotherapy and radiation therapy) for adults, the initial dose is 100 mg 1 time per day for 5 days, then 100 mg after 72 hours. The course Galavit of treatment is 20-30 injections.
Galavit rectal suppositories Galavit:
Suppositories are released from the blister strip packaging and injected into the rectum. Before this, it is recommended to empty the intestines. The dose and duration of the drug depends on the severity and duration of the disease.
For infectious diseases of various etiologies (including septic conditions, hepatitis B and C, meningitis), the initial dose for adults is 0.2 g. Then they switch to administering the drug 0.1 g 2-3 times a day until symptoms of intoxication and inflammation are eliminated. then it is possible to continue the course of therapy with the drug at a dose of 0.1 g 1 time in 2-3 days. The duration of the course Galavit depends on the patient's condition (up to 25 suppositories per course).
In diseases of the gastrointestinal tract (gastric ulcer and duodenal ulcer, ulcerative colitis, Crohn's disease) and the genitourinary system, the initial dose for adults in the acute period is 0.2 g 1 time per day for 1-2 days, then they switch to the administration of the drug at 0 , 1 g 1 time in 2-3 days. The course of treatment is 15–25 suppositories, depending on the patient's condition.
With uterine fibroids , 0.1 g / day is prescribed daily for 5 days, then - 0.1 g 1 time in 2-3 days. The course of treatment is 15–20 suppositories.
In case of benign prostatic hyperplasia, the drug is prescribed daily at 0.1 g / day for 5 days, then - at 0.1 g 1 time in 2-3 days.
For purulent-septic processes in the pre- and postoperative period, as well as for the prevention of postoperative infectious complications in adults, 0.1 g of the drug is prescribed before or after surgery 1 time per day for 5 days, then 0.1 g every other day (5 suppositories), then - 0.1 g each after 72 hours; the course of treatment is 15 suppositories
In chronic recurrent furunculosis, adults in the first 5 days are prescribed 0.1 g 1 time per day, then 0.1 g every other day. The course of treatment is up to 20 suppositories.
For chronic recurrent herpes infection: for adults in the first 10 days - 0.1 g once a day, then 0.1 g every other day. The course of treatment is up to 25 suppositories.
In chronic inflammatory diseases that have developed against the background of an immunodeficiency state, adults are prescribed 0.1 g 1 time in 3 days or 0.1 g daily for 5 days, then - 1 time in 2-3 days. The course of treatment is 20 suppositories.
For immunocorrection in oncological diseases: breast cancer stage III, lung cancer stage III (in combination with chemotherapy and radiation therapy) for adults, the initial dose is 0.1 g every other day (5 suppositories), then 0.1 g at intervals 72 hours. The course of treatment is 20-30 suppositories.
Contraindications Galavit:
Hypersensitivity to the components of the drug, during pregnancy and lactation.
Side effects Galavit:
Not identified.
special instructions Galavit:
There is no experience of application in pediatrics.
Interactions Galavit:
Not described.
Overdose Galavit:
Overdose cases are not described.
