Instructions for Gluconorm (Glibenclamide, Metformin) 40 pills
English product name Gluconorm
Gluconorm
Release form
Coated tablets
Description Gluconorm:
The tablets, covered with a film shell of white or almost white color, are round, double-convex; on a white-to-white fracture with a grayish tint of color.
1 tab.
glybenclamide 2.5 mg
metformin hydrochloride 400 mg
Auxiliary substances: cellulose microcrystalline - 100 mg, cornstarch - 20 mg, silicon dioxide colloid - 20 mg, gelatin - 10 mg, glycerol - 10 mg, magnesium stearate - 7 mg, refined talc - 15 mg, sodium croskarmellose - 30 mg, sodium carboxymethyl starch - 18.3 mg, cellacefate - 2 mg, diethyl phthalate - 0.2 mg.
10 pcs - blister packs (4) - cardboard packs.
20 pcs. - blister packs (2) - cardboard packs.
ATC codes
A10BD02 Metformin in combination with sulfonyl urea derivatives
Clinical-pharmacological groups / Group affiliation
Oral hypoglycemic preparation
Active substance
metformin hydrochloride
glybenclamide
Pharmacotherapy group:
Hypoglycemic oral agent (II generation sulfonyl urea+biguanide)
Storage Conditions
The drug should be stored in a dry, light-proof place, inaccessible to children at a temperature not higher than 25 ° C.
Best before date
Shelf life is 3 years.
Testimony Gluconorm:
- Type 2 diabetes in adults:
- Failure of diet, exercise and prior metformin or glybenclamide therapy
- for replacement of the previous therapy with two drugs (metformin and glybenclamide) in patients with stable and well-controlled blood glucose levels.
Method of use, course and dosage Gluconorm:
The drug is used internally, during meals. The dose of the drug is determined by the doctor individually for each patient depending on the level of blood glucose.
Usually the initial dose is one tablet. (400 mg/2.5 mg)/day
Every one to two weeks after starting treatment, the dose of the preparation is correlated with the blood glucose level. In the replacement of the previous combination therapy with metformin and glybeclamide, one or two tablets are prescribed. The Gluconorm depends on the previous dose of each component.
The maximum daily dose is five tablets.
Application for kidney disorders Gluconorm
Use is contraindicated for severe kidney dysfunction and acute conditions that may lead to changes in kidney function (dehydration, severe infection, shock);
Use in liver disorders
Contraindicated in liver failure
Terms of Sale
The drug is prescription.
Application in elderly patients
It is not recommended to use the drug in persons over 60 years of age who perform heavy physical work, which is associated with an increased risk of developing lactacidosis.
- Nosology (ICD codes)
- E11
- Type 2 diabetes
Pharmacological effect Gluconorm:
- Gluconorm® is a fixed combination of two oral hypoglycemic agents of different pharmacological groups: metformin and glybenclamide.
- Metformin belongs to the biguanide group and reduces serum glucose levels by increasing the sensitivity of peripheral tissues to insulin and enhancing glucose uptake. Reduces carbohydrate absorption in the gastrointestinal tract and inhibits gluconeogenesis in the liver. The drug also has a beneficial effect on the lipid profile of the blood, reducing the level of total cholesterol. LDL and triglycerides. It does not cause hypoglycemic reactions.
- Glybenclamide belongs to the group of sulfonyl urea derivatives of generation II. The invention stimulates insulin secretion by reducing the glucose irritation threshold of pancreatic β cells, increases insulin sensitivity and the degree of insulin binding to target cells, increases insulin release, increases the insulin effect on glucose uptake by muscles and liver, and inhibits lipolysis in adipose tissue. It is active in the second phase of insulin secretion.
