indications for Heptor
Description Heptor:
Hepatoprotective agent.
Structure Heptor:
Active substance:
Ademetionine tosylate disulfate in terms of ademetionine ion - 400 mg.
Excipients in the medicine:
Indications for use of the drug:
- Intrahepatic cholestasis, pre-cirrhotic and cirrhotic conditions, which can occur with the following diseases:
- fatty liver
- chronic hepatitis
- Toxic liver disease of various etiologies, including alcoholic, viral, drug (antibiotics, antitumor, anti-tuberculosis and antiviral drugs, tricyclic antidepressants, oral contraceptives)
- chronic noncalculous (acalculous) cholecystitis
- cholangitis
- cirrhosis of the liver
- encephalopathy, incl. associated with liver failure (alcoholic, etc.).
- Intrahepatic cholestasis in pregnant women.
- Symptoms of depression in humans
Pharmacokinetics Heptor:
After a single oral administration of the tablet at a dose of 400 mg Cmax of ademetionine in plasma is reached after 2-6 hours.
It is 0.7 mg / l. The bioavailability of the drug for oral administration is 5%, with intramuscular administration - 95%.
Serum protein binding is negligible.
Penetrates the BBB. Regardless of the route of administration, a significant increase in the concentration of ademetionine in the cerebrospinal fluid is observed. Metabolized in the liver. T1 / 2 - 1.5 hours. It is excreted by the kidneys from the body.
Pharmacodynamics Heptor:
The drug is hepatoprotective, has antidepressant activity.
It has choleretic and cholekinetic, detoxifying, regenerating, antioxidant, anti-fibrotic and neuroprotective properties.
The drug compensates for the deficiency of ademetionine and stimulates the substance to be produced in the body; it is found in all environments of the body.
Contraindications medication
Genetic disorders affecting the methionine cycle and / or causing homocystinuria or hyperhomocysteinemia (cystathione beta synthase deficiency, impaired vitamin B12 metabolism (cyanocobalamin)
bipolar disorder
Precautions
Pregnancy (I trimester) and the period of breastfeeding (use is possible only if the potential benefit to the mother outweighs the possible risk to the fetus or child).
Concomitant use with selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (such as clomipramine), as well as with herbal preparations and preparations containing tryptophan. Elderly age. Renal failure
Side effects:
From the nervous system: there may be headache and insomnia.
From the digestive system: there may be abdominal pain, diarrhea, dryness of the oral mucosa, dyspepsia, flatulence, nausea.
Method of preparation or use of Heptor:
Inside.
The tablets should be taken whole, without chewing, preferably in the morning between meals.
The tablets of the drug Heptor must be removed from the blister immediately before ingestion.
Initial therapy:
The recommended dose is 10-25 mg / kg / day. Intrahepatic cholestasis The dose ranges from 800 mg / day to 1600 mg / day.
With Depression Heptor:
the dose ranges from 800 mg / day to 1600 mg / day. The duration of therapy is determined by the attending physician.
Elderly patients
Clinical experience of using the drug Heptor did not reveal any differences in its effectiveness in elderly and young patients.
However, given the high likelihood of existing disorders of the liver, kidneys or heart, other concomitant pathology or simultaneous therapy with other drugs. The dose of tablets should be selected with caution in elderly patients, starting from the lower limit of the drug. range
The use of the drug Heptor is contraindicated for children !!!
(efficacy and safety have not been established).
1. HP1s modulate the S-Adenosyl Methionine synthesis pathway in liver cancer cells
2. Mechanism of Radical Initiation in the Radical S-Adenosyl-l-methionine Superfamily
3. https://pubmed.ncbi.nlm.nih.gov/30346729/
4. S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life
5. S-Adenosyl Methionine in the Therapy of Depression and Other Psychiatric Disorders