Hexoral (Hexetidine) 0,1% 200 ml

Instructions for Hexoral

Dosage form Hexetidine:

transparent liquid of red color with a mint smell.

The writing
Composition for 100 ml of hexoral solution:
active substance of the drug: hexetidine 0.1 g;

excipients of the drug: ethanol 96% - 4.3333 g, polysorbate 60 - 0.7 g, peppermint oil - 0.064 g, anise oil - 0.0392 g, citric acid monohydrate - 0.0418 g, sodium saccharin - 0.022 g , levomenthol - 0.0186 g, methyl salicylate - 0.0186 g, clove oil - 0.0084 g, eucalyptus oil - 0.0011 g, azorubin 85% (E 122) - 0.0023 g, purified water - up to 100 ml 

general description
Antiseptic.

Special conditions Hexetidine:

solution for topical application, can be used for rinsing the mouth and throat only if the patient can spit the solution after rinsing.
Applying the drug for topical use does not affect the ability to drive vehicles and engage in other potentially hazardous activities.

Drug interactions 
No data available.
Pharmacodynamics
The antimicrobial effect of the drug "Hexoral®" is associated with the suppression of oxidative reactions of bacterial metabolism (thiamine antagonist). The drug has a wide spectrum of antibacterial and antifungal effects (in particular, against gram-positive bacteria and fungi of the genus Candida). Hexetidine has a weak anesthetic effect on the mucous membrane.
The drug has an antiviral effect against influenza A viruses, respiratory syncytial virus (RS virus), herpes simplex virus type 1, affecting the respiratory tract.

Pharmokinetics Hexoral:

Hexetidine adheres very well to the mucous membrane and is practically not absorbed.

After a single application of the active substance, traces of it are found on the gingival mucosa for 65 hours. In dental plaque, active concentrations remain for 10-14 hours after application.

Indications Hexoral:

As a symptomatic remedy.
• Symptomatic treatment for inflammatory and infectious diseases of the oral cavity and larynx:
- tonsillitis, tonsillitis (including Plaut-Vincent tonsillitis, tonsillitis of lateral ridges), pharyngitis, gingivitis, stomatitis, glossitis, periodontal disease;
- fungal diseases;
• prevention of infectious complications before and after surgical interventions on the oral cavity and larynx and in case of trauma, including prevention of infection of the alveoli after tooth extraction;
• hygiene of the oral cavity, including for eliminating bad breath

Contraindications Hexoral:

• Hypersensitivity to any component of the drug;
• erosive-desquamous lesions of the oral mucosa;
• children under 3 years old.
WITH CAUTION: in case of hypersensitivity to acetylsalicylic acid.
APPLICATION DURING PREGNANCY AND DURING BREASTFEEDING
There is no information about any undesirable effects of the drug "Hexoral®" during pregnancy and during breastfeeding. However, before prescribing Hexoral® to pregnant or lactating women, the doctor should carefully weigh the benefits and risks of treatment, given the lack of sufficient data on the penetration of the drug through the placenta and into breast milk.

Overdose Hexoral:

It is unlikely that the active substance hexetidine can have a toxic effect if the instructions for use of the medicinal product are followed.

Swallowing large amounts of hexetidine solution containing ethanol may result in signs / symptoms of alcohol intoxication.

Side effects Hexoral:

Adverse reactions identified during post-marketing use of the drug were classified as follows: very frequent (≥1 / 10), frequent (≥1 / 100, <1/10), infrequent (≥1 / 1000, <1/100) , rare (≥1 / 10000, <1/1000), very rare (<1/10000), frequency unknown (incidence cannot be estimated from the available data).

Immune system disorders. Very rare: hypersensitivity reactions (including urticaria), angioedema.
Nervous system disorders. Very rare: ageusia, dysgeusia.
Disturbances from the respiratory system, chest and mediastinal organs. Very rare: cough, shortness of breath due to the appearance of a hypersensitivity reaction.