Instructions for Ketonal DUO (ketoprofen) modified release capsules
Release form
Modified release capsules
Ketoprofen: Main characteristics
ATC Code: M01AE03
Pharmacological group: Nonsteroidal anti-inflammatory drugs (NSAIDs)
Active ingredient: Ketoprofen
Pharmacological effect Ketonal DUO:
Ketoprofen belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDs). It has pronounced anti-inflammatory, analgesic and antipyretic properties. The mechanism of action of ketoprofen is inhibition of the enzyme cyclooxygenase (COX-1 and COX-2), leading to inhibition of prostaglandin synthesis, including production in the central nervous system (CNS), especially the hypothalamus. The drug also stabilizes liposomal membranes and, at high concentrations, inhibits the synthesis of bradykinin and leukotrienes. It is important to note that ketoprofen does not adversely affect the articular cartilage.
Indications for use Ketonal DUO:
- Ketoprofen is used for the symptomatic treatment of pain caused by various inflammatory processes. Key indications include
- Rheumatoid arthritis
- Seronegative arthritis (ankylosing spondylitis, psoriatic arthritis, reactive arthritis)
- Gout and pseudogout
- Degenerative disorders of the musculoskeletal system, such as osteoarthrosis
- Headache.
- migraine
- tendinitis and bursitis,
- myalgia and neuralgia and radiculitis
- Post-traumatic and post-operative pain syndrome, including cases with inflammation and fever
- Cancer pain syndrome in humans
- Algodysmenorrhoea
- Ketoprofen is effective in managing a wide range of pain syndromes, from moderate to severe, and can be used in a variety of medical situations where rapid and effective pain
- relief is required.
Method of application, course of treatment and dosage
The medicine can be used orally, rectally or by injection.
When taken by mouth, both the dose and the frequency of use are individually selected depending on the medical indications and the form of the preparation.
For rectal administration, the recommended dose is 100 mg once or twice daily.
The intravenous or intramuscular dose is equal to 100-200 mg, the frequency of administration being determined on the basis of the indications and the clinical picture.
Parenteral ketoprofen may be combined with other forms of ketoprofen, such as tablets, capsules, and rectal suppositories. The maximum permissible dose of ketoprofen per day should not exceed 200 mg.
- Nosology ketoprofen (ICD codes)
- G43
- Migraine
- M02.3
- Reiter's disease
- M05
- Seropositive rheumatoid arthritis
- M07
- Psoriatic and enteropathic arthropathies
- M10
- Gout
- M13.9
- Arthritis, unspecified
- M15
- Polyarthrosis
- M19.9
- Arthrosis, unspecified
- M25.5
- Joint pain
- M42
- Osteochondrosis of spine
- M45
- Ankylosing spondylitis
- M47
- Spondylosis
- M54.1
- Radiculopathy
- M54.3
- Ishias
- M54.4
- Lumbago with sciatica
- M65
- Synovitis and tenosynovitis
- M70
- Soft tissue diseases associated with stress, overload, and pressure
- M71
- Other bursopathies
- M79.1
- Myalgia
- M79.2
- Neuralgia and neuritis, unspecified
- N94.4
- Primary dysmenorrhea
- N94.5
- Secondary dysmenorrhea
- R51
- Headache
- R52.0
- Acute pain
- R52.2
- Other persistent pain (chronic)
- T14.3
- Dislocation, sprain, and straining of capsulo-ligamentous apparatus of joint of unspecified region of body
- T14.8
- Other injuries to unspecified region of body
