Instructions for L-Optic-Rompharm (Levofloxacin) eye drops 0.5%, 5 ml
Description L-Optic-Rompharm:
Antimicrobial agent is fluoroquinolone.
Composition L-Optic-Rompharm:
1 ml of the preparation contains: active substance: levofloxacin hemihydrate in terms of levofloxacin - 5.00 mg; excipients.
Indications for use L-Optic-Rompharm:
Treatment of superficial bacterial eye infections caused by sensitive microorganisms in adults and children over 1 year old.
Prevention of complications after surgical and laser eye surgeries.
When using the drug, official national
guidelines for the appropriate use of antibacterial drugs, as well as the sensitivity of pathogenic microorganisms in a particular country, should be taken into account .
Pharmacokinetics L-Optic-Rompharm:
After instillation into the eye, levofloxacin is well preserved in the tear film.
In studies on healthy volunteers, it was shown that the average concentrations of levofloxacin in the tear film, measured 4 and 6 hours after topical application, were 17.0 μg / ml and 6.6 μg / ml, respectively. In five out of six volunteers, levofloxacin concentrations were 2 μg / ml and higher 4 hours after instillation. In four out of six volunteers, this concentration remained 6 hours after instillation.
The average concentration of levofloxacin when using eye drops in aqueous humor is statistically significantly higher than the average concentration of ofloxacin (p = 0.0008). In fact, it is approximately twice as high as the average concentration of ofloxacin (1139.9 ± 717.1 ng / ml and 621.7 ± 368.7 ng / ml, respectively).
The average concentration of levofloxacin in blood plasma 1 hour after application is from 0.86 ng / ml on the 1st day to 2.05 ng / ml. The maximum concentration of levofloxacin in plasma, equal to 2.25 ng / ml, was detected on the 4th day after two days of using the drug every 2 hours up to 8 times a day. The maximum concentrations of levofloxacin reached on the 15th day are more than 1000 times lower than those observed after ingestion of standard doses of levofloxacin.
Pharmacodynamics L-Optic-Rompharm:
Levofloxacin is a synthetic broad-spectrum antibacterial drug from the group of fluoroquinolones. The active substance contains levofloxacin - the levorotatory isomer of ofloxacin.
Levofloxacin blocks DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts supercoiling and stitching of DNA breaks, inhibits DNA synthesis, and causes deep morphological changes in the cytoplasm, cell wall and membranes of microbial cells.
Contraindications L-Optic-Rompharm:
Hypersensitivity to levofloxacin, to excipients of the drug L-Optic-Rompharm, as well as to other quinolones.
Children up to age 1 year.
With caution
If the drug is used in children, be sure to consult your doctor before taking the drug.
Side effects L-Optic-Rompharm:
Immune system disorders: rarely - systemic allergic reactions, incl. skin rash; very rarely - anaphylactic shock.
Nervous system disorders: infrequently - headache.
Disturbances from the organ of vision: often - burning in the eye, decreased vision, filamentous mucous discharge in the conjunctival cavity; infrequently - chemosis, conjunctival injection, papillary conjunctivitis, eyelid edema, eyelid erythema, eye discomfort, itching in the eye, eye pain, dry eye syndrome, photophobia.
Disturbances from the respiratory system, chest and mediastinal organs: infrequently - rhinitis, very rarely - laryngeal edema.
If you have any side effects indicated in the instructions, or they are aggravated, or you notice any other side effects not listed in the instructions, inform your doctor.
Method of preparation or use L-Optic-Rompharm:
Topically in the affected eye. The duration of the course of treatment is determined by the severity of the condition, its clinical and bacteriological characteristics. The average duration of the course of therapy is 5 days. 1-2 drops into the affected eye (s) every 2 hours up to 8 times a day during wakefulness during the first 2 days, then four times a day from 3 to 5 days. When using several drugs, the interval between their instillations should be at least 15 minutes.
Vacation procedure:
According to the form of prescription form 107-1 / y
