Structure:
One tablet
Active substances
Magnesium Lactate Dihydrate - 470 mg
in terms of magnesium (Mg2 +) - 48 mg
Pyridoxine hydrochloride - 5 mg
Excipients: sucrose (white sugar) - 27.4 mg, kaolin - 41.0 mg, acacia gum (gum arabic) - 25.0 mg, collidone® SR [polyvinyl acetate 80%, povidone (K 30) 19%, sodium lau -rylsulfate 0.8%, silicon dioxide 0.2%] - 34.0 mg, magnesium stearate - 6.8 mg, sodium carmellose - 34.0 mg, talc -6.8 mg.
Shell composition: sucrose (white sugar) - 166.7 mg, kaolin - 54.0 mg, gelatin - 0.9 mg, acacia gum (gum arabic) - 4.0 mg, beeswax - 0.4 mg, titanium dioxide - 9.0 mg, talc - 15.0 mg.
general description
A drug that replenishes the deficiency of magnesium in the body
Special conditions:
Information for patients with diabetes: tablets contain sucrose as an excipient.
In the case of concomitant calcium deficiency, magnesium deficiency should be eliminated before taking calcium supplements.
With the frequent use of laxatives, alcohol, intense physical and mental stress, the need for magnesium increases, which can lead to the development of a deficiency of magnesium in the body.
Impact on the ability to drive vehicles and other mechanisms:
The drug does not adversely affect the driving of vehicles and the performance of potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.
Drug interaction:
- The simultaneous use of drugs containing phosphates or calcium salts can significantly reduce the absorption of magnesium in the gastrointestinal tract.
- Magnesium preparations reduce the absorption of tetracycline, it is recommended to divide the intake of these drugs with a three-hour interval.
- Magnesium weakens the effect of oral thrombolytic agents, reduces the absorption of iron.
- Vitamin B6 inhibits the activity of levodopa.
Pharmacodynamics:
Replenishes magnesium deficiency.
Magnesium is a vital element that is found in all body tissues and is necessary for the normal functioning of cells. Participates in most metabolic reactions, in the regulation of transmission of nerve impulses and in muscle contraction, has an antispasmodic, antiarrhythmic and antiaggregant effect.
The body receives magnesium along with food. A lack of magnesium in the body can be observed with a violation of the diet (diet) or with an increase in the need for magnesium (with increased physical and mental stress, stress, pregnancy, the use of diuretics).
Pyridoxine (vitamin B6) is involved in many metabolic processes, in the regulation of the metabolism of the nervous system. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells.
Serum Magnesium Content:
- from 12 to 17 mg / l (0.5-07 mmol / l) indicates moderate magnesium deficiency;
- below 12 mg / l (0.5 mmol / l) indicates a severe deficiency of magnesium.
Pharmacokinetics:
Absorption of magnesium in the gastrointestinal tract is 50% of the oral dose. It is excreted mainly through the kidneys. In the kidneys, after glomerular filtration of 70% of the magnesium present in plasma, it is reabsorbed by the renal tubules in a proportion of 95-97%.
Indications
An established magnesium deficiency, isolated or associated with other deficient conditions, accompanied by symptoms such as: increased irritability; minor sleep disturbances; gastrointestinal cramps; cardiopalmus; fatigue; muscle pains and cramps, tingling sensation in the muscles.
Contraindications:
Hypersensitivity to the components of the drug, severe renal failure (creatinine clearance less than 30 ml / min), sucrose / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.
Children under 6 years old.
Carefully:
With moderate renal failure, as there is a risk of developing hypermagnesemia.
Pregnancy and lactation:
Pregnancy
Clinical experience has not revealed fetotoxic or fetal developmental defects. Magnelis® B6 can be used during pregnancy only as directed by a doctor.
Breastfeeding period
Magnesium passes into breast milk.
Avoid the use of the drug during breastfeeding.
Overdose:
With normal renal function, oral administration of magnesium does not cause toxic reactions. Magnesium poisoning can develop in renal failure. Toxic effects mainly depend on the serum magnesium content.
Overdose symptoms: drop in blood pressure, nausea, vomiting, slowing reflexes, anuria, respiratory depression, coma, cardiac arrest.
Treatment: rehydration, forced diuresis. In renal failure, hemodialysis or peritoneal dialysis is necessary.
Side effects:
From the digestive tract: abdominal pain, constipation, nausea, vomiting, flatulence.
Allergic reactions: allergic reactions to the components of the drug are possible.
Ways of application:
Before taking the drug, you must consult your doctor.
Adults are advised to take 6-8 tablets per day.
Children over 6 years old (weighing more than 20 kg) 4-6 tablets per day.
The daily dose should be divided into 2-3 doses, taken with food, washed down with a glass of water.
Treatment should be discontinued after normalizing the concentration of magnesium in the blood.