Instructions for Nicotinic Acid
- Acute hepatitis a
- Acute hepatitis b
- Acute hepatitis c
- Chronic viral hepatitis b without delta agent
- Chronic viral hepatitis C
- Thyrotoxicosis [hyperthyroidism]
- Deficiency of niacin [pellagra]
- Pure hypercholesterolemia
- Pure hyperglyceridemia
- Mixed hyperlipidemia
- Hyperchylomicronemia
- Facial nerve lesions
- Diabetic polyneuropathy (E10-E14 + with common fourth character .4)
- Brain infarction
- Atherosclerosis
- Raynaud's syndrome
- Thromboangiitis obliterans [berger's disease]
- Unspecified peripheral vascular disease
- Peripheral angiopathy in diseases classified elsewhere
- Varicose veins of the lower extremities with ulcers and inflammation
- Gastritis and duodenitis
- Crohn's disease [regional enteritis]
- Other non-infectious gastroenteritis and colitis
- Chronic hepatitis, not elsewhere classified
- Fibrosis and cirrhosis of the liver
Pharmacological group Nicotinic Acid:
Vitamin B
pharmachologic effect Nicotinic Acid:
Vitamin and lipid-lowering agent. In the body, nicotinic acid is converted to nicotinamide, which binds to the coenzymes of codehydrogenase I and II (NAD and NADP), which carry hydrogen, and is involved in the metabolism of fats, proteins, amino acids, purines, tissue respiration, glycogenolysis, and synthetic processes. Replenishes the deficiency of vitamin PP (vitamin B 3), is a specific antipellagric agent (vitamin PP vitamin deficiency). Normalizes the concentration of blood lipoproteins; in high doses (3-4 g / day orally) reduces the concentration of total cholesterol, LDL, TG, reduces the cholesterol / phospholipid index, increases the content of HDL, which has an antiatherogenic effect. It has a vasodilating effect at the level of small vessels (including the brain), improves microcirculation, has a weak anticoagulant effect (increases the fibrinolytic activity of the blood).
The hypocholesterolemic effect is noted after a few days, the decrease in TG - a few hours after administration.
Nicotinic Acid
Side effects Nicotinic Acid:
From the side of the cardiovascular system: hyperemia of the skin of the face and upper half of the body with a tingling sensation and burning sensation, with rapid administration - a decrease in blood pressure, orthostatic hypotension, collapse.
From the side of the central nervous system and peripheral nervous system: paresthesia, dizziness.
From the digestive system: with prolonged use - fatty degeneration of the liver.
From the side of metabolism: with prolonged use - hyperuricemia, decreased glucose tolerance, increased blood levels of AST, LDH, ALP.
Local reactions: soreness at the site of s / c and i / m injections.
Others: allergic reactions.
Nicotinic Acid
special instructions Nicotinic Acid:
Use with caution orally in patients with hemorrhages, glaucoma, gout, hyperuricemia, liver failure, arterial hypotension, hyperacid gastritis, gastric ulcer and duodenal ulcer (in remission).
Use parenterally with caution in patients with hemorrhages, glaucoma, liver failure, arterial hypotension, hyperacid gastritis, gastric ulcer and duodenal ulcer (in the acute phase).
With prolonged use of nicotinic acid in high doses, it is possible to develop fatty liver infiltration.
During treatment, it is necessary to monitor liver function.
It is inappropriate to use for the correction of dyslipidemia in patients with diabetes mellitus.
To prevent complications from the liver, it is recommended to include in the diet foods rich in methionine (cottage cheese) or to use methionine, lipoic acid and other lipotropic agents.
Nicotinic Acid
In case of impaired liver function Nicotinic
Use with caution in patients with hepatic impairment.
With prolonged use of Nicotinic acid in high doses, it is possible to develop fatty liver infiltration.
During treatment, it is necessary to monitor liver function. To prevent complications from the liver, it is recommended to include in the diet foods rich in methionine (cottage cheese) or to use methionine, lipoic and other lipotropic agents.
Nicotinic Acid
Drug interactions Nicotinic Acid:
Care must be taken when combining with antihypertensive drugs, anticoagulants and acetylsalicylic.
Nicotinic acid reduces the toxicity of neomycin and prevents the decrease in cholesterol and HDL levels it induces.
