Instructions for Valacyclovir 500 mg
Compound
1 tablet contains:
Active ingredient:
valacyclovir hydrochloride 556.20 mg, equivalent to valacyclovir 500.00 mg;
Excipients (core):
corn starch 56.80 mg, colloidal silicon dioxide 2.00 mg, croscarmellose sodium 29.00 mg, magnesium stearate 4.00 mg, microcrystalline cellulose (type 101) 72.00 mg;
Excipients (shell): Opadry II white: 22.00 mg (macrogol (polyethylene glycol) 5.19 mg, polyvinyl alcohol 10.32 mg, talc 3.83 mg, titanium dioxide [E171] 2.66 mg).
pharmachologic effect
Pharmacotherapeutic group: antiviral agent
ATX code: J05AB11
Pharmacodynamics
Mechanism of Action
Valacyclovir is an anti-virus drug that is an acyclovir ester with L-valine. Acyclovir is an analog of guanine, a purine nucleoside.
In humans, valacyclovir rapidly converts to acyclovir and valine, probably under the influence of the enzyme valacyclovirhydrolase. Acyclovir is a specific herpesvirus inhibitor, with activity against HSV-1, HSV-2, VZV, CMV, EBV, and HHV-6. It prevents viral DNA synthesis immediately after phosphorylation and conversion to an active form, acyclovirtriphosphate. The first stage of phosphorylation requires the activity of virus-specific enzymes. For example, for HSV-1, HSV-2, and EBV, the viral thymidine kinase enzyme is present only in infected cells by the virus. The partial selectivity of phosphorylation is carried out in CMV indirectly through the phosphotransferase gene product UL97. The need for acyclovir to be activated by a specific viral enzyme largely explains its selective action.
Indications
- Persons aged 12 to 18 years and adults:
- Therapy of herpes simplex (HSV) skin and mucosal infections, including primary and secondary genital herpes (herpes genitalis) and also herpes
- labialis (herpes labialis)
- Preventing (suppressing) recurrence of herpes simplex virus, including genital herpes, infection of the skin and mucous membranes in
- immunocompromised adults
- Preventing cytomegalovirus (CMV) infections and disorders after parenchymal organ transplantation
- adults:
treatment of herpes zoster (herpes zoster) and eye herpes zoster (ophthalmic)
How to take, course of reception and dosage
Intake and dosage, method of taking, course of treatment - by mouth, regardless of food intake, it is necessary to instill water tablets.
Treatment of herpes simplex virus (HSV) skin and mucous membrane infections, including primary and recurrent genital herpes (herpes genitalis) and lip herpes (herpes labialis)
Adults and adolescents 12 to 18 years with a normal immune system should take 500 mg twice a day.
