Venous tone, [Phlebodia 600] reduces inflammation, Diosmin 600 mg 30 tablets

Instructions for Venous tone, [Phlebodia 600] reduces inflammation, Diosmin 600 mg 30 tablets

Composition [Phlebodia 600]:
1 film-coated tablet contains:

The composition of the tablet core:
Active ingredient: diosmin - 600.0 mg.
Excipients: microcrystalline cellulose, povidone K 30, colloidal silicon dioxide, magnesium stearate.
The composition of the shell of the tablet 1: Opadry II pink (85F34610) (polyvinyl alcohol, titanium dioxide, macrogol 3350, talc, iron oxide yellow, iron oxide red, iron oxide black).
The composition of the shell of the tablet 2: shellac.

Special conditions [Phlebodia 600]:
Treatment of an acute attack of hemorrhoids is carried out in combination with other drugs, in the absence of a quick clinical effect, it is necessary to conduct an additional examination and adjust the therapy.
In cases of impaired venous circulation (varicose veins of the lower extremities, chronic lymphovenous insufficiency of the lower extremities), the maximum treatment effect is ensured by a combination of therapy with lifestyle changes: it is advisable to avoid a long stay in an upright position and reduce excess body weight. In some cases, wearing special stockings (compression hosiery) helps to improve blood circulation.
If there is no decrease or aggravation of the symptoms of the disease, consult a doctor!
Do not exceed the maximum dates and recommended doses of the drug without consulting your doctor!
The effect of the drug on the ability to drive vehicles, mechanisms
Given the possibility of developing adverse reactions from the nervous system (dizziness), during the treatment period, you should carefully drive vehicles and engage in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.
Drug interaction
Clinically significant effects of interaction with other drugs are not described.
Inform your healthcare provider about all medications you are taking.

Pharmacodynamics [Phlebodia 600]:
Venotonic effect: reduces the extensibility of veins, increases venous tone, reduces venous congestion, enhances the vasoconstrictor effect of adrenaline, norepinephrine.
One tablet contains 600 mg of diosmin, which is the optimal effective daily dose for venotonic action.
Angioprotective effect: improves microcirculation, increases capillary resistance, reduces their permeability.
Effect on the lymphatic system: improves lymphatic drainage, increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure.
It has a decongestant effect. Reduces the symptoms of inflammation (dose-dependent effect).
Reduces the adhesion of leukocytes to the venous wall and their migration into paravasal tissues; improves oxygen diffusion and perfusion in tissue. It blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.
In clinical studies, it was confirmed: a decrease in the average venous pressure in the system of superficial and deep veins of the lower extremities, demonstrated in a double-blind, placebo-controlled study conducted under the control of dopplerography, as well as an increase in systolic and diastolic blood pressure in patients with postoperative orthostatic hypotension.

Pharmacokinetics [Phlebodia 600]:
After oral administration, the drug is rapidly absorbed from the gastrointestinal tract and is determined in blood plasma after 2 hours. The maximum plasma concentration is reached 5 hours after administration. It is evenly distributed and accumulates in all layers of the walls of the vena cava and saphenous veins of the lower extremities, to a lesser extent in the kidneys, liver, lungs and other organs. Selective accumulation of diosmin and / or its metabolites in venous vessels reaches a maximum by 9 hours after administration and persists for 96 hours. It is excreted mainly by the kidneys (79%), as well as by the intestines (11%) and with bile (2.4%).
Indications
Treatment of symptoms of lymphovenous insufficiency of the lower extremities (feeling of heaviness, fatigue, fullness in the legs, pain, worse by the end of the day, swelling).
Treatment of symptoms of acute hemorrhoids.
Additional treatment for microcirculation disorders.

Contraindications:
Hypersensitivity to the components of the drug, children under 18 years of age (experience with use is limited), not recommended during breastfeeding (experience with use is limited).
Use during pregnancy and during breastfeeding
Pregnancy
Use during pregnancy is possible only as prescribed by the doctor in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
In experimental studies, no teratogenic effects on the fetus were detected. To date, in clinical practice there have been no reports of cases of malformation or fetotoxic effects on the fetus when using the drug in pregnant women.
Breastfeeding period
Due to the lack of data on the penetration of the drug into breast milk, lactating women are not recommended to take the drug.

Overdose [Phlebodia 600]:
Symptoms of an overdose are not described.
Side effects
The incidence of adverse reactions is presented as follows: very often
(≥ 1/10), often (≥ 1/100, <1/10), infrequently (≥ 1/1000. <1/100), rarely (≥ 1/10000, <1/1000), very rarely (< 1/10000, including individual reports), frequency is unknown (there is currently no evidence of prevalence of side effects).
From the gastrointestinal tract: rarely - dyspeptic disorders (heartburn, nausea, abdominal pain).
From the central nervous system: rarely - headache.
If any of the side effects indicated in the instructions are aggravated or you notice any other side effects not listed in the instructions, inform your doctor.

Ways of application:
The drug is intended for oral administration.
Lymphatic insufficiency outside the lower extremities
In chronic lymphovenous insufficiency, 1 tablet is prescribed per day in the morning, preferably before meals. Usually the course of taking the drug is 2 months.
Acute hemorrhoids and exacerbation of chronic hemorrhoids
In acute hemorrhoids and exacerbation of chronic hemorrhoids, the drug is prescribed in the first four days, 1 tablet 3 times a day with meals, in the next three days, 1 tablet
2 times a day with meals. In case of recurrence of symptoms, the course of treatment can be repeated on the recommendation of a doctor.

Chronic hemorrhoids
After stopping acute events, it is recommended to continue taking the drug according to
1 tablet 1 time per day for 1-2 months. If one or several doses of the drug is missed, it is necessary to continue the use of the drug Diosmin in the usual mode and in the usual dose.
Before using the drug, consult your doctor.