ACC for cough (Acetylcysteine)

Instructions for use ACC from cough:

Description: ACC from cough:

Mucolytic drug.

Composition ACC from cough:

1 sachet contains: acetylcysteine

Indications for use ACC from cough:

• Diseases of the respiratory system
• accompanied by the formation of viscous difficult to separate sputum
• acute and chronic bronchitis
• obstructive bronchitis
• laryngotracheitis; Acetylcysteine
• pneumonia
• bronchiectasis
• bronchial asthma
• bronchiolitis
• cystic fibrosis
• acute and chronic sinusitis
• otitis media (otitis media).

Pharmacokinetics ACC from cough:

The absorption is high. Oral bioavailability is 10%, which is due to the pronounced effect of the "first pass" through the liver. Time to reach Cmax in blood plasma is 1-3 hours.
Plasma protein binding is 50%. Penetrates the placental barrier. There are no data on the ability of acetylcysteine to penetrate the BBB and be excreted in breast milk.
Metabolism and excretion
It is rapidly metabolized in the liver to form a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides.
It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). T1 / 2 is about 1 hour.

Pharmacokinetics ACC from cough:

Liver dysfunction leads to an increase in T1 / 2 up to 8 hours.

Pharmacodynamics ACC from cough:

The presence of sulfhydryl groups in the structure of acetylcysteine contributes to the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. It has a mucolytic effect, facilitates sputum discharge due to a direct effect on the rheological properties of sputum. The drug remains active in the presence of purulent sputum.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Contraindications ACC from cough:

Hypersensitivity, pregnancy, lactation.

Side effects ACC from cough:

Rarely, headache, inflammation of the oral mucosa (stomatitis),
and tinnitus may occur. It is extremely rare - diarrhea
vomiting
heartburn and nausea
decreased blood pressure
increased heart rate (tachycardia)
In isolated cases
allergic reactions are observed, such as bronchospasm (mainly in patients with bronchial hyperreactivity), skin rash, itching and urticaria. In addition, there are isolated reports of the development of bleeding due to the presence of hypersensitivity reactions.

With the development of side effects, you should stop taking the drug and consult a doctor.

Method of preparation or use ACC from cough:

Inside.
Adults - 200 mg 2-3 times a day in the form of granules (powder), tablets or capsules. Children 2-6 years old - 200 mg 2 times a day or 100 mg 3 times a day in the form of a water-soluble granulate (powder); under 2 years old - 100 mg 2 times a day; 6-14 years old - 200 mg 2 times a day. For chronic diseases for several weeks: for adults - 400-600 mg / day in 1-2 doses; children 2-14 years old - 100 mg 3 times a day; with cystic fibrosis - children from 10 days to 2 years old - 50 mg 3 times a day, 2-6 years old - 100 mg 4 times a day, over 6 years old - 200 mg 3 times a day in the form of a water-soluble granulate (powder), an effervescent tablet or in capsules.

Vacation procedure ACC from cough:

No limits

Storage conditions ACC from cough:

Store in a dry place out of the reach of children at a temperature not exceeding 25 ° C.