Allopurinol pills

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Instructions for Allopurinol pills

English Product Name
Allopurinol

Dosage form
tab. 100 mg: 50 pcs

Description:

Tablets of white or white with a creamy shade of color, flat-cylindrical shape with a chamfer.

1 tab.
Allopurinol 100 mg
Excipients: sucrose (refined granulated sugar) - 20 mg, potato starch - 77.68 mg, magnesium stearate (magnesium stearic acid) - 1 mg, food gelatin - 1.32 mg.

10 pcs. - packs of cellular contour (5) - packs of cardboard.
50 pcs. - cans of dark glass (1) - packs of cardboard.

ATX Codes
M04AA01 Allopurinol

Clinical and pharmacological groups / Group affiliation
A drug that affects the exchange of uric acid. Anti-gouty drug

Active ingredient
Allopurinol

Pharmaco-therapeutic group
Antigout, xanthine oxidase inhibitor

pharmachologic effect:

A tool that disrupts the synthesis of uric acid. It is a structural analogue of hypoxanthin. Inhibits the enzyme xanthine oxidase, which is involved in the conversion of hypoxanthin to xanthine and xanthine to uric acid. This is due to a decrease in the concentration of uric acid and its salts in the body's fluids and urine, which helps to dissolve the existing urate deposits and prevents their formation in the tissues and kidneys. When taking Allopurinol, the excretion of hypoxanthin and xanthine in the urine increases.

Dosage, Course and Dosage Allopurinol:

Install individually, under the control of the concentration of urates and uric acid in the blood and in the urine. Adults when taken orally - 100-900 mg per day, depending on the severity of the course of the disease. The frequency of admission is two to four times a day after meals. Children under the age of 15 years - ten - twenty mg / kg / day or 100-400 mg / day.

Maximum doses: in case of impaired renal function (including those caused by urate nephropathy) - one hundred mg per day. An increase in the dose is possible in cases where, against the background of the therapy, an increased concentration of urates in the blood and urine persists.

Testimony Allopurinol:

Treatment and prevention of gout and hyperuricemia of various genesis (including in combination with nephrolithiasis,
renal failure,
urate nephropathy).
Recurrent mixed oxalate-calcium kidney stones in the presence of hyperuricosuria.
Increased formation of urates due to enzyme disorders.
Prevention of acute nephropathy in cytostatic and radiation therapy of tumors and leukemia, as well as in complete
therapeutic fasting.

Use in case of impaired liver function
Contraindication: pronounced violations of liver function. With caution, Allopurinol should be used for impaired liver function (dose reduction is necessary).

Use in children
In children, it is used only for malignant neoplasms (especially leukemias), as well as for some enzyme disorders (Lesch-Nyhen syndrome).

The dosage regimen is set individually, under the control of the concentration of urates and uric acid in the blood and urine: children under the age of 15 years - 10-20 mg / kg / day or 100-400 mg / day.