Instructions for Azithromycin
Composition Azithromycin:
Azithromycin 250mg;
Auxiliary islands: lactose,
corn starch,
magnesium stearate,
sodium lauryl sulfate.
Indications Azithromycin:
- Infectious and inflammatory diseases,
- caused by microorganisms sensitive, incl. bronchitis,
- pneumonia,
- infections of the skin and soft tissues
- otitis media,
- sinusitis,
- pharyngitis,
- tonsillitis,
- gonorrheal and non-urethral urethritis and / or cervicitis,
- Lyme disease (borreliosis)
Pharmacodynamics Azithromycin:
The macrolide is a representative of azalides.
Suppresses RNA-dependent protein synthesis of susceptible microorganisms.
Active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes / group A /); Gram-negative bacteria:
Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter, using the cream, using the creamy, to protect them, using a cream anaerobic bacteria: Bacteroides fragilis. is also active against Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, Treponema pallidum. Active also against Toxoplasma gondii
Pharmacokinetics Azithromycin:
Rapidly absorbed from the digestive tract
Eating reduces the absorption of Cmax in plasma is reached in 2-3 hours.
It is rapidly distributed in tissues and biological fluids. 35% of is metabolized in the liver by demethylation.
More than 59% is excreted in the bile unchanged, about 4.5% in the urine in unchanged form.
Side effects Azithromycin:
On the part of the digestive system: nausea, vomiting, flatulence, diarrhea, abdominal pain, transient increase in liver enzymes; rarely - cholestatic jaundice.
Allergic reactions:
rarely - skin rash,
angioedema,
erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Dermatological reactions Azithromycin:
rarely - photosensitization. Co CNS: dizziness, headache; rarely - drowsiness, weakness. From the hematopoietic system: rarely - leukopenia, neutropenia, thrombocytopenia.
Since the cardiovascular system: rarely - chest pain. From the genitourinary system: vaginitis; rarely - candidiasis, nephritis, increase in residual urea nitrogen.
Other: rarely - hyperglycemia, arthralgia.
Special conditions Azithromycin:
Not recommended for use in patients with impaired liver function.
With caution used for violations of the kidneys. Azithromycin/ should be taken at least 1 hour before or 2 hours after meals or antacids.
Indications Infectious and inflammatory diseases caused by microorganisms sensitive to including bronchitis, pneumonia, infections of the skin and soft tissues, otitis media, sinusitis, pharyngitis, tonsillitis, gonorrhea and non-gonorrhea urethritis and / or cervicitis, Lyme disease (borreliosis).
Contraindications Azithromycin
Hypersensitivity to Azithromycin and other macrolide.
Drug Interactions Azithromycin:
With simultaneous use with ergot alkaloids, the risk of ergotism development cannot be excluded. With the simultaneous use of azithromycin with warfarin, cases of enhancing the effects of the latter are described.
With simultaneous use of digoxin or digitoxin, a significant increase in the concentration of cardiac glycosides in the blood plasma and the risk of glycoside intoxication may occur.
With simultaneous use with disopyramide described the case of ventricular fibrillation. When applied simultaneously with lovastatin, cases of rhabdomyolysis are described.
With simultaneous use of rifabutin increases the risk of developing neutropenia and leukopenia.
With the simultaneous use of disturbed metabolism of cyclosporine, which increases the risk of adverse and toxic reactions caused by cyclosporine.
Dosage Azithromycin:
Set individually, taking into account the nosological form, the severity of the disease and the sensitivity of the pathogen. Adults inside - 0.25-1 g 1 time /; children - 5-10 mg / kg 1 time / Duration of treatment 2-5 days.
