Instructions for Bromhexin 4 mg 60 ml
Pharmaceutical properties:
Bromgexin, cyclohexyl-N-methyl-(2-amino-3-5-dibromobenzyl)-amino chloride, is a synthetic derivative of a plant-based substance (vasina) . Bromgexin provides sectolitis and secretomotor action in the bronchial tract, resulting in increased bronchial secretion, reduced viscosity of the mucous (wet), increased resnitus epithel activity, which contributes to the evacuation of the syl and (wet). Simultaneous use of Bromhexin with amoxicillin, erythromycin and oxytetracycline leads to local increases in the concentration of these antibiotics in wet and bronchial secrecy. After the intake, the Bromhexin is almost completely absorbed. The half-life period is approximately 0.4 hours. The primary-flow effect is approximately 80%, and biologically active metabolites are formed. Bromhexine doesn't accumulate. Linking to blood plasma proteins is 99%. Bromgexine penetrates through the placenta, the CMJ and breast milk. It is produced mainly by kidneys in the form of metabolites.
indications for use:
- Acute and chronic diseases of bronches and lungs
- accompanied by formation of a difficult separable viscous secret (as part of secret and secretomotor therapy).
Application:
The drug in the form of r-ra and in the form of a drage is prescribed inside after eating with enough liquid. Children under 6 years of age, as well as patients with body weight ≤ 50 kg — 4-8 mg 3 times a day, which corresponds to 12-24 mg of Bromhexin hydrochloride per day; 6-14 years - 8 mg 3 times a day; Children over 14 years of age and adults - 8-16 mg (1-2 draz) of the drug 3 times a day, which corresponds to 24-48 mg of Bromhexin hydrochloride per day. The duration of treatment depends on the evidence, course of the disease and is determined individually, but should not exceed 4-5 days without the consultation of the doctor.
In case of kidney or liver diseases severe dosage of the drug should be reduced.
Contraindications:
Increased drug sensitivity, pregnancy and breast feeding. Relative contraindications are peptic stomach ulcer and duodenum, bronchus diseases, accompanied by excessive accumulation of bronchial secret, kidney function impairment, severe liver diseases.
Side Effects:
When analyzing side effects, the following frequency values are taken as the basis: very often (≥1/10), often (≥1/100 and ≤1/10), sometimes (≥1/1000 and ≤1/100), rarely (≥1/1000 and ≤1/ 1000), very rarely (≤1/10 000), unknown (available information does not allow to estimate this effect).
Allergic reactions: sometimes — fever, hypersensitivity reactions (skin rash, angionevrotic swelling, respiratory disturbances, itching, nettle), bronchospasm; very rarely — anaphylactic reactions, including anaphylactic shock.
On the LCT side: sometimes — nausea, pain in the epigastral region, vomiting, diarrhea, dyspeptic phenomena, passing an increase in the level of activity of amino transferraz in the plasma of blood.
On the skin side: very seldom — Stevens-Johnson syndrome, Lyell syndrome.
Special Instructions:
Carefully, the drug is used in patients with peptic stomach ulcer or duodenal intestines and by indications for gastrointestinal bleeding in anamnesis.
When any skin or mucous membranes first appear during the use of Bromhexin hydrochloride, it is necessary to immediately stop the use of the drug (perhaps it is the beginning of the development of severe complications such as Stevens's - Johnson syndrome or Lyell's syndrome). The drug should be used with caution in case of violation of bronchial motor, which is accompanied by formation of a large number of bronchial secret (primary cyliar diskinesia).
In case of kidney or liver diseases, the gadrochloride Bromhexin must be used with special care: reduce the dose or increase the interval between receptions. In case of kidney failure of a severe degree, it is possible to expect accumulation of Bromhexin metabolites, which are formed in the liver. For long-term therapy, it is recommended to periodically control liver function.
In hereditary intolerability of halactose or fructose, in the case of glucose/halactose malabsorption syndrome or in the case of hereditary insufficiency of sakharazy-isomaltaza, the appointment of Bromgexyexin the form of Berlin
Use during pregnancy and breastfeeding. During pregnancy and breastfeeding, the drug is prescribed taking into account the ratio of the benefit to the mother/risk for the fetus (the child).
Ability to influence the speed of reaction when driving vehicles or working with other mechanisms. No data.
Use in children. Bromgexin Berlin-Hemi in 8 mg dragee form is not intended for use in children under 6 years of age.
Interactions:
When applied simultaneously with drugs capable of irritating the mucous membrane of the digestive tract, it is possible to strengthen their irritating effect. When combined using bromgexin with anti-cough remedies in connection with the oppression of cough reflex can develop a dangerous stalemate of the bronchial secret, therefore such therapy requires special care. Simultaneous use of Bromhexin with antibiotics (e.g. erythromycin, cefalexin, oxytetracyclin, ampicillin, amoxicillin) improves their penetration in the pulmonary tissue.
Overdose:
Severe overdoses have not been recorded so far.
Symptoms:
Single cases of overdose: vomiting, consciousness disorder, ataxia, diplopia, tachypnoe, metabolic acidosis of a mild degree. In young children, after taking Bromhexin at a dose of 40 mg, no overdose symptoms were observed.
Treatment:
In case of severe overdose, it is necessary to monitor the performance of the cardiovascular system, symptomatic therapy. Due to the high degree of enlistment with blood plasma proteins, the high volume of distribution and the slow reverse distribution of Bromhexin from tissues to blood, it is not expected to increase the injection of the drug in hemodialysis or forced diuresis.
Retention Terms:
At a temperature not exceeding 15 °C.
