Instructions for Bromhexin 8 mg 25 dragee
Active ingredients
Bromhexine
Release form
Pills
Composition:
1 dragee:Bromhexine hydrochloride 8 mg.Excipients: lactose monohydrate-34.4 mg, corn starch-14.6 mg, gelatin-1.8 mg, silicon dioxide colloidal-0.6 mg, magnesium stearate-0.6 mg.Shell composition: sucrose-27.704 mg, calcium carbonate-4.326 mg, magnesium carbonate-1.507 mg, talc-1.507 mg, macrogol 6000-1.75 mg, povidone K25-0.243 mg, glucose syrup-1.639 mg, Carnauba wax-0.012 mg, titanium dioxide (E171) - 1.166 mg, quinoline yellow (E104) - 0.146 mg.
Pharmacological effect:
Mucolytic agent with expectorant action. Reduces the viscosity of bronchial secretions by depolarizing the acidic polysaccharides contained in it and stimulating the secretory cells of the bronchial mucosa that produce a secret containing neutral polysaccharides. It is believed that bromhexine promotes the formation of a surfactant.
pharmacokinetics:
Bromgexin is quickly absorbed from the gastrointestinal tract and undergoes intense metabolism when the first passage through the liver. Bioavailability is about 20%. In healthy patients, Cmax in plasma is determined after 1 hour. About 85-90% is excreted in urine mainly in the form of metabolites. The metabolite of bromhexin is ambroxol. T1/2 in the terminal phase is about 12 hours Bromgexin penetrates through geb. Only small amounts are excreted in the urine with T1/2 6.5 tsp. Clirense bromgexin or its metabolites may decrease in patients with severe liver and kidney dysfunction.
Indications for the use of jelly:
Treatment of respiratory diseases, accompanied by the formation of a incurable viscous secret:
tracheobronchitis
chronic bronchitis with bronchodative component
asthma Cystic fibrosis
chronic pneumonia.
Contraindications:
Increased bromhexin sensitivity.
Precautions:
Do not exceed recommended doses.
Use in pregnancy and breastfeeding
In pregnancy and lactation, bromhexine is used in cases where the intended benefit to the mother exceeds the potential risk to the fetus or child.
Method of application and dose:
Inside adults and children 10 - 8 mg 3-4 times/day. Children under 2 years - 2 mg 3 times/day; 2 to 6 years - 4 mg 3 times/day; 6 to 10 years - 6-8 mg 3 times/day. If necessary, the dose can be increased by adults up to 16 mg 4 times/day, children - up to 16 mg 2 times/day. Inhalation by the drug to adults - up to 8 mg, children over 10 years - up to 4 mg, children from 6 to 10 years - 2 mg.
Up to 6 years - use Bromhexin in doses of up to 2 mg. Inhalation is carried out twice a day. Therapeutic action Bromhexin can manifest on the 4-6th day of treatment. Parenteral administration is recommended for treatment in severe cases, as well as in the postoperative period to prevent the accumulation of dense moisture in the bronchi.
Injected Bromhexin 2 mg n/k, inside the muscle or inside 2-3 times/day slowly for 2-3 minutes.
Side Actions:
From the digestive system: dyspeptic phenomena, transistor increase of liver transaminase activity in blood serum. On the part of the CNS: headaches, dizziness.Dermatological reactions: high sweating, skin rash. On the side of the respiratory system: cough, bronchospasm.
Overdose:
Symptoms: headache, nausea, vomiting.Treatment: symptomatic. There's no specific antidote.
Interaction with other drugs
Bromhexine is incompatible with alkaline solutions.
Special Instructions:
Bromgexin should be used under the control of a doctor in cases of stomach ulcer disease, as well as in cases of signs of gastric bleeding in anamnesis.With caution, it should be used in patients suffering from bronchial asthma.Bromgexin is not used simultaneously with drugs containing codec. It is used in combination preparations of vegetable origin with essential oils (including eucalyptus oil, anise oil, mint oil, pepper). Noah, Mentol).
