Instructions for Chymotrypsin lyophilisate for solution preparation 10 mg
Chymotrypsin lyophilisate for solution preparation 10 mg
English product name
Chymotrypsin
Release Form
Lyophilizate for preparation of solution for injection, local and external application
Description Chymotrypsin
Lyophilizate for preparation of solution for injection, local and external application in the form of tablets, dressers, powder, plates or shiny scales of white color.
1 fl
chemotrypsin* 10 mg
* derived from the pancreas of cattle.
Glass bottles with a capacity of 5 ml (5) - packs of cardboard.
Glass bottles with a capacity of 5 ml (10) - packs of cardboard.
ATC codes
D03BA Proteolytic enzymes
Clinical-pharmacological groups / Group affiliation
Preparation having proteolytic activity
Active substance
chymotrypsin
Pharmaco-therapeutic group
Proteolytic agent
Storage Conditions
The drug should be stored in a place inaccessible to children, protected from light at a temperature not higher than 25 ° C.
Best before date
The shelf life is three years. Do not apply after expiry date.
Pharmacological effect Chymotrypsin
Hydrolyzes proteins and peptons to form relatively low-molecular peptides, cleaves residues-formed bonds of aromatic amino acids (tyrosine, tryptophan, phenylalanine, methionine).
In medical practice, the use of Chymotrypsin is based on a specific feature of cleaving necrotised tissue and fibrinose formations, diluting viscous secretions, exudates and blood clots, and when applied in / m to have an anti-inflammatory effect. In relation to healthy tissues, the enzyme is inactive and safe.
Method of use, course and dosage Chymotrypsin
For b/m administration, 5 mg of the preparation is dissolved immediately prior to administration into one -2 ml of 0.9% sodium solution of the chloride for injection or 0.5-2% solution of procaine. The course of treatment is 6-15 injections.
For respiratory diseases, the preparation is used in doses of 5-10 mg/day for 10-12 days, possibly combined with the use of Chymotrypsin aerosol in 5% aqueous solution in amounts of three to four ml. After 7-10 days the treatment can be repeated.
In the treatment of burns and pressure sores, Chymotrypsin is dissolved in 20 ml of 0.25% procaine solution in a dose of 20 mg and is injected under the scab with a fine needle with several injections.
The pus-filled wound surfaces are coated with 8 h sterile wipes soaked with a solution of 25-50 mg of Chemotrypsin in a 10-50 ml 0.25% procaine solution. For the treatment of suppurative wounds, the drug is combined with topical wound treatment with tampons dipped with 5% aqueous solution of Chymotrypsin.
In the case of thrombophlebitis, the preparation is administered in/m of 5-10 mg daily for 7-10 days.
In the case of cataract extraction, Chymotrypsin diluted with 1:5000 is introduced into the rear eye chamber followed by washing the front eye chamber with a 0.9% sodium chloride solution after 4 minutes of administration of the preparation.
Subconjunctival 0.2 ml of 5% solution, prepared with 1% procaine solution, is administered subconjunctivially, once - twice a week, in the treatment of the central retinal vein thrombosis and acute obstruction of the central retinal artery Chemotripsin.
In the case of sinusitis, the preparation is introduced into the appropriate cavity in an amount of 5-10 mg in 3-5 ml 0.9% of the sodium chloride solution after puncturing and washing the cavity.
In otites, 0.5-1 ml 0.1% of Chymotrypsin solution is buried in the ear with a 0.9% sodium chloride solution.
A 0.1% solution of Chemotrypsin is introduced into the cavity during surgery during microoperations on the ear in order to soften fibrinose formations in the middle ear. At the same time, Chymotrypsin should be administered in/m of 2.5-5 mg once - twice a day. The preparation is diluted in 1-2 ml of 0.25-0.5% of procaine solution or 0.9% of sodium chloride solution for injection.
Testimony Chymotrypsin
- Acute respiratory diseases (bronchiectasis, pneumonia,
- abscess of the lungs,
- atelectasis,
- exudative pleuritis,
- pleuria empyema,
- bronchitis);
- burns;
- run over;
- pus wounds;
- thrombophlebitis;
- periodontitis (inflammatory-dystrophic forms);
- in ophthalmology - fresh extensive thromboses of the central vein of the retina, acute obstruction of the central artery of the
- retina, clouding of the vitreous body of traumatic and inflammatory origin,
- extraction of cataracts;
- In otolaryngology - pus sinusitis,
- Laryngotracheitis, after tracheostomy to facilitate the removal of thick viscous exudate, in
- acute, subacute,
- suppurative,
- chronic middle otitis and Eustaitis with viscous exudate.
Nosology Chymotrypsin (ICD codes)
- H34
- Occlusion of retinal vessels
- H43.3
- Other clouding of glassy body
- H59.0
- Keratopathy (bullseye aphacia) after cataract surgery
- H66
- Pus and unspecified mean otitis
- H68
- Inflammation and blockage of the auditory [eustachian] tube
- I80
- Phlebitis and thrombophlebitis
- J01
- Acute sinusitis
- J04
- Acute laryngitis and tracheitis
- J15
- Bacterial pneumonia not classified elsewhere
- J20
- Acute bronchitis
- J32
- Chronic sinusitis
- J37
- Chronic laryngitis and laryngotracheitis
- J42
- Chronic bronchitis unspecified
- J47
- Bronchiectasis
- J85
- Abscess of the lung and mediastinum
- J86
- Piothorax (Pleura Empyema)
- J90
- Pleural effusion
- J98.1
- Pulmonary collapse (incl. atelectasis)
- K05
- Gingivitis and periodontal diseases
- L89
- Decubital ulcer and pressure area
- T30
- Thermal and chemical burns of unspecified location
- T79.3
- Post-traumatic wound infection not classified elsewhere
- Z93.0
- Presence of tracheostoma