Instructions for Clindacin (Clindamycin) vaginal suppositories
Active ingredients:
Clindamycin
Release form:
Suppositories (candles)
Composition Clindacin:
Clindamycin (as phosphate) 100 mg Excipients:
semi-synthetic glycerides (such as "Estarinum", "Witepsol" or "Suppocir").
Pharmacological effect Clindacin:
An from the group of lincosamides, has a broad spectrum of antimicrobial action. The mechanism of action is due to binding to the 50 S subunit of the ribosomal membrane and suppression of protein synthesis in the microbial cell. Acts bacteriostatically. A bactericidal effect is possible against a number of gram-positive cocci.; Active against Staphylococcus spp. (including Staphylococcus epidermidis, producing and non-producing penicillinase), Streptococcus spp. (excluding Enterococcus faecalis), Streptococcus pneumoniae, Corynebacterium diphtheriae, Mycoplasma spp., anaerobic and microaerophilic gram-positive cocci (including Peptococcus spp. and Peptostreptococcus spp.),
Clostridium perfringens, Clostridterium spp. (including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubacterium spp. and Actinomyces israelii .; Most strains of Clostridium perfringens are sensitive to clindamycin, but other Clostridium spp. (including Clostridium sporogenes, Clostridium tertium) are resistant to its action, therefore, determination is recommended for infections caused by Clostridium spp.; Cross-resistance exists between and lincomycin.
Pharmacokinetics Clindacin:
After a single intravaginal injection of clindamycin at a dose of 100 mg, 4% of the administered dose undergoes systemic absorption. Cmax in plasma - 20 ng / ml.
Indications Clindacin:
Bacterial vaginosis caused by microorganisms sensitive to the drug.
Contraindications Clindacin:
I trimester of pregnancy; hypersensitivity to the components of the drug.
Application during pregnancy and lactation
Intravaginal use of Clindacin during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus. Clindamycin crosses the placental barrier into the circulatory system of the fetus.; Clindamycin is excreted in breast milk. It is recommended to prescribe the drug with caution during lactation. During treatment, breastfeeding should be discontinued.
Method of administration and dosage Clindacin:
Assign intravaginally 1 suppository 1 time / day immediately before bedtime, for 3-7 days in a row.; Before use, one suppository is freed from the contour packaging, after cutting the film along the contour of the suppository, injected, if possible, deep into the vagina, in the supine position ...
Side effects Clindacin:
From the reproductive system: cervicitis, vaginitis, vulvovaginal irritation.; From the hematopoietic organs: rarely - reversible leukopenia, neutropenia, eosinophilia, agranulocytosis, thrombocytopenia.; Allergic reactions: maculopapular rash, urticaria, itching.; Other: other systemic side effects are possible, incl. in rare cases - pseudomembranous enterocolitis.
Overdose Clindacin:
Due to the low absorption of the drug, overdose is unlikely.
Interaction with other drugs:
enhances the action of drugs rifampicin, aminoglycosides - streptomycin, gentamicin.; Enhances muscle relaxation caused by n-anticholinergic blockers. incompatible with erythromycin, ampicillin, diphenylhydantoin derivatives, barbiturates, aminophylline, calcium gluconate and magnesium sulfate.
special instructions Clindacin:
Influence on the ability to drive vehicles and control mechanisms; The drug does not affect the ability to concentrate and the speed of psychomotor reactions.
