Composition:
dexamethasone sodium phosphate 1 mg gentamicin sulfate 5 mg, incl. gentamicin 3 mg Excipients: benzalkonium chloride (preservative), potassium hydrogen phosphate, potassium dihydrogen phosphate, sodium chloride, water d / i.
Pharmacodynamics:
Combined preparation for topical use in ophthalmology. The drug provides a sufficient dose and compatibility of both active components, and also reduces the likelihood of errors in the selection of the dose in case of separate appointment of the components included in the drug.
Gentamicin is a water-soluble antibiotic of the aminoglycoside group. It has a bactericidal effect against a wide range of gram-positive and gram-negative bacteria. Gentamicin does not cross the intact cornea.
Damage and inflammation of the cornea lead to the penetration of gentamicin through the cornea into the anterior chamber of the eye 15 minutes after instillation of eye drops or ocular ointment.
Dexamethasone is a synthetic GCS, the anti-inflammatory and anti-allergic effect of which is 25 times higher than the action of cortisol, which is a natural endogenous GCS. The penetration of dexamethasone through the cornea with intact epithelium into the moisture of the anterior chamber of the eye is possible; however, in the event of an inflammatory process or damage to the epithelium, the rate of penetration of dexamethasone through the cornea significantly increases.
Pharmacokinetics:
When applied topically, systemic absorption is low. Side effects From the side of the organ of vision: rarely - allergic reactions, burning sensation after using the drug; with prolonged use - the development of secondary glaucoma, steroid cataract.
Special conditions:
With a duration of use of the drug for more than 2 weeks, as well as in patients with an indication of open-angle and closed-angle glaucoma in history, it is recommended to regularly monitor intraocular pressure. If the use of contact lenses is necessary, then they should be removed before using Dex-Gentamicin in the form of eye drops and installed again no earlier than 20 minutes later.
The patient should be informed that in case of side effects should immediately stop treatment and consult an ophthalmologist. Use in pediatrics To date, there are no clinical studies of the safety and effectiveness of the use of Dex-Gentamicin in children. The use of the drug in pediatrics is possible if the expected therapeutic effect exceeds the potential risk of side effects.
Effect on the ability to drive vehicles and control mechanisms Immediately after the use of the drug Dex-Gentamicin, a short-term violation of visual acuity may occur, leading to a slowdown in psychomotor reactions. Therefore, it is not recommended to use the drug immediately before working with mechanisms and driving vehicles.
Indications:
Infectious and inflammatory eye diseases caused by microorganisms sensitive to gentamicin: - conjunctivitis; - keratitis; - blepharitis; - barley.
Allergic processes of the anterior eye, complicated by a bacterial infection. Prevention and treatment of inflammatory phenomena in the postoperative period (after cataract removal and anti-glaucoma surgery).
Contraindications:
- keratitis caused by Herpes simplex or Varicella zoster viruses (treelike keratitis); - viral diseases of the cornea and conjunctiva (including with chickenpox); - mycobacterial infections of the eyes; - fungal diseases of the eyes; - acute purulent eye diseases with lesions of the corneal epithelium; - corneal epithelialopathy; - increased intraocular pressure; - Hypersensitivity to the components of the drug. During the use of the drug, it is not recommended to use contact lenses. Drug interaction
Drug Interactions:
Dex-Gentamicin is not described.
Dosage:
Dex-Gentamicin eye drops are instilled in the conjunctival sac 1-2 drops 4-6 times / A strip of ointment 1 cm long is placed in the conjunctival sac 2-3 During the application of the eye ointment, the tube should not be contacted with the surface of the skin or conjunctiva. The duration of treatment with Dex-Gentamicin usually does not exceed 2-3 weeks.
The duration of therapy is determined by the effectiveness of the drug, the severity of symptoms and the likelihood of side effects. With the simultaneous use of several ophthalmic drugs, it is recommended to lay Dex-Gentamicin in the form of an eye ointment no earlier than 15 minutes after using eye drops.
Overdose:
When using the drug Dex-Gentamicin, an overdose is unlikely.
