Instructions for Diclofenac solution
ATX codes
M01AB05 Diclofenac
Clinical and pharmacological groups / Group affiliation Diclofenac
NSAIDs
Active ingredient
sodium diclofenac
Pharmacotherapeutic group
NSAIDs
Retention conditions
In a place protected from light at a temperature of 15 to 25 °C. Freezing is not allowed. Keep away from children.
Expiration date
The expiration date is two years.
Pharmacological effect Diclofenac
Diclofenac has anti-inflammatory, analgesic and antipyretic effects. Indiscriminate cyclooxygenase 1 and 2, interferes with arachidonic acid metabolism, and reduces prostaglandins in the inflammation site. In rheumatic diseases, the anti-inflammatory and analgesic effects of diclofenac can dramatically reduce pain, morning stiffness, and joint swelling, improving joint function. Diclofenac reduces pain and inflammatory edema in trauma and the postoperative period.
Testimony Diclofenac
- For short-term treatment of pains of different genesis, moderate intensity:
- musculoskeletal disorders (rheumatoid arthritis, psoriatic, juvenile chronic arthritis, ankylosing spondyloarthritis; gouty arthritis, soft-tissue rheumatic disease, osteoarthritis of the peripheral joints and spine (including radicular syndrome) The drug is intended for symptomatic treatment, reducing pain and inflammation at the time of use, does not affect the progression of the disease;
- lumbago, sciatica, neuralgia;
- Algodysmenorrhea, pelvic inflammatory processes, including adnexitis;
- Post-traumatic pain syndrome with inflammation
- post-operative pain.
Method of use, course and dosage Diclofenac
Injected deeply into a muscle. The adult dose is 75 mg (1 ampoule). If necessary, it can be readministered but no sooner than in 12 hours. Other forms of diclofenac should not exceed the maximum daily dose of -one hundred fifty mg.
Duration of use does not exceed two days, if necessary, then transfer to oral or rectal use of diclofenac.
Pharmacokinetics
It is absorbed by mouth from the gastrointestinal tract. Food intake slows the rate of absorption without affecting absorption. About fifty percent of the active ingredient is metabolized in the "first passage" through the liver. The time to achieve Cmax in plasma after ingestion is two to four hours, depending on the formulation used. The concentration of active ingredient in plasma is in a linear relationship with the amount of dose applied.
- Nosology (ICD codes)
- M05
- Seropositive rheumatoid arthritis
- M07
- Psoriatic and enteropathic arthropathies
- M08
- Juvenile [juvenile] arthritis
- M10
- Gout
- M15
- Polyarthrosis
- M25.5
- Pain joint
- M42
- Osteochondrosis of spine
- M45
- Ankylosing spondylitis
- M54.1
- Radiculopathy
- M54.3
- Ischias
- M54.4
- Lumbago with sciatica
- M70
- Soft tissue diseases related to stress, strain, and pressure
- M79.0
- Rheumatism, unspecified
- M79.2
- Neuralgia and neuritis, unspecified
- N70
- Salpingitis and oophoritis
- N71
- Inflammatory disease of uterus, except cervix (including endometritis, myometritis, metritis, pyometra, uterine abscess)
- N72
- Inflammatory disease of cervix (including cervicitis, endocervicitis, exocervicitis)
- N94.4
- Primary dysmenorrhea
- N94.5
- Secondary dysmenorrhoea
- R52.0
- Acute pain
- R52.2
- Other persistent pain (chronic)
- T14.3
- Dislocation, sprain, and straining of capsule ligament system of joint of unspecified body region
