Instructions for Dicynone (Etamsylate) Pills
Pharmacological properties:
Preparation for preventing and stopping bleeding. It affects the first stage of the hemostasis mechanism (the interaction between endothelium and platelets). Dicinone increases platelet adhesion, normalizes capillary wall strength (reducing their permeability), inhibits prostaglandin biosynthesis, which causes platelet disaggregation, vasodilation, and increases capillary permeability.
When used internally, the drug Etamsylate is almost completely absorbed into the gastrointestinal tract, reaching peak concentrations in the blood serum 4 hours after ingestion. About 72% of the dose taken is excreted with urine unchanged for 24 hours.
After the administration of the preparation, the hemostatic effect is noted after 5-15 minutes, the maximum therapeutic effect is achieved during 1 hour. The effectiveness of the preparation begins to decrease after 4-6 hours. After administration in a dose of 500 mg, the maximum level in blood plasma is achieved after 10 minutes and is 50 ug/ml. Approximately 72% of the administered dose is excreted for 24 hours with the urine in the same state. Etamzilate penetrates the placental barrier and penetrates the breast milk.
Testimony Dicynone:
Tablets
Prevention and treatment of bleeding during and after surgical operations in otolaryngology, gynecology, obstetrics, urology, dentistry, ophthalmology, plastic surgery;
prevention and treatment of capillary bleeding of different etiology and location: Hematuria, metrorragia, primary menorragia in women with intrauterine contraceptives, nosebleeds, bleeding from gingivitis.
P-r for injection:
in neonatology (the drug Etamsylate is prescribed as an angioprotector until microcirculation normalizes).
Application
Tablets
Daily dose is: 1-2 tablets 3-4 times a day. In severe cases, the dose is 3 pills 3-4 times a day. For menorrhogia, 3-4 tablets per day are prescribed, starting 5 days before the expected menstruation and until the 5th day of the next menstrual cycle.
After surgery, 1-2 pills are used every 6 hours until the risk of bleeding disappears.
P-r for injection
Applicable in/in (slow) or in/m. The optimal dose for adults is 10-20 mg/kg of etamzylate and is administered in 3-4 doses. In most cases, the daily dose is 1-2 ampoules 3-4 times a day.
Prior to an operational intervention, 1-2 ampoules are introduced into/into or into/into/out. During the operation, 1-2 ampoules are introduced into/in; the same dose can be repeated. After the operation, 1-2 ampoules are administered every 6 hours until the risk of bleeding disappears.
In neonatology, Dicinone is administered in/m or b/v in doses of 12.5 mg/kg (0.1 ml=12.5 mg). Treatment should be started within the first 2 hours after birth and administered every 6 hours for 4 days to a total dose of 200 mg/kg.
Dicinone can be used locally (skin graft, tooth extraction) using a sterile gauze cloth dipped with the drug Etamsylate.
Contraindications:
Increased sensitivity to the components of the drug Dicynone, acute porphyria, hemoblastosis in children. Increased blood clotting.
Side effects Dicynone:
Tablets
Rarely - nausea, pain in the epigastria, dizziness, skin rash.
P-r for injection: Headache, dizziness, facial hypocrisy, transient skin reactions, nausea, pain in the epigastria, paresthesia of the lower extremities. Sometimes - reduction of systolic pressure after the injection of the drug Etamsylate. These side effects are mild and transient.
Special Instructions:
Before starting treatment, other causes of bleeding must be eliminated.
The preparation is used with caution in patients with thrombosis and thromboembolies in the anamnesis. The preparation is ineffective in reducing the number of platelets.
Period of pregnancy and breastfeeding. The safety of the drug Dicynone is not established. Dicinone is only allowed to be taken if the potential benefit to the mother exceeds the potential risk to the fetus. Breastfeeding should be stopped when the drug is used.
Influence on the ability to drive vehicles and machinery. Not affected.
Tablets should be taken during meals or after meals.
Do not use the product in case of a change in color of the product.
Interactions
The p-r for injection is not compatible with the sodium p-r of hydrogen carbonate and with the sodium powder of lactate. The contents of the ampoule should not be mixed with other drugs Etamsylate in the same syringe. If Dicynon is mixed with physiological p-rom, it should be used immediately.
Tablets
Interactions with other drugs Etamsylate have not been established.
Overdose
No data.
Storage Conditions
In a dry place protected from light at temperatures up to 25 °C.