Composition Eleflox:
levofloxacin (in the form of hemihydrate) 500 mg
general description Eleflox:
Fluoroquinolone, a broad-spectrum antimicrobial bactericidal agent
Special conditions Eleflox:
Levofloxacin is used with caution in elderly patients (a high probability of the presence of a concomitant decrease in renal function).
After normalizing the temperature, it is recommended to continue treatment for at least 48-78 hours. The duration of iv infusion of 500 mg (100 ml of infusion solution) should be at least 60 minutes. During treatment Eleflox, it is necessary to avoid solar and artificial UV radiation in order to avoid damage to the skin (photosensitivity). When signs of tendonitis appear, levofloxacin is immediately canceled. It should be borne in mind that in patients with a history of brain damage (stroke, severe trauma), seizures may develop, with glucose-6-phosphate dehydrogenase deficiency, there is a risk of hemolysis.
Influence on the ability to drive vehicles and control mechanisms
During the treatment period, it is necessary to refrain from engaging in potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions. levofloxacin
Drug Interactions Eleflox:
Levofloxacin increases T1 / 2 of cyclosporine.
The effect of levofloxacin is reduced by drugs that inhibit intestinal motility, sucralfate, magnesium and aluminum-containing antacids and iron salts (a break between taking at least 2 hours is necessary).
With the simultaneous use of NSAIDs, theophylline increases convulsive readiness, GCS - increase the risk of tendon rupture.
Cimetidine and drugs that block tubular secretion slow down the excretion of levofloxacin.
The solution of levofloxacin for iv administration is compatible with 0.9% sodium chloride solution, 5% dextrose solution, 2.5% Ringer's solution with dextrose, combined solutions for parenteral nutrition (amino acids, carbohydrates, electrolytes).
A solution of levofloxacin for iv administration cannot be mixed with heparin and solutions having an alkaline reaction.
Pharmacodynamics Eleflox:
Fluoroquinolone, Eleflox a broad-spectrum antimicrobial bactericidal agent. It blocks DNA gyrase (topoisomerase II) and topoisomerase IV, disrupts supercoiling and cross-linking of DNA breaks, inhibits DNA synthesis, and causes deep morphological changes in the cytoplasm, cell wall and membranes. Effective against Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus agalactiae, Viridans group streptococci, Enterobacter cloacae, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter sakazakii, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Klebsiella oxytoca, Legionella pneumoniae, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa, Pseudomonas fluorescens, Chlamydia pneumoniae, Mycoplasma pneumoniae, Acinetobacter anitratus, Acinetobacter baumannii, Acinetobacter calcoaceticus, Bordetella pertussis, Citrobacter diversus, Citrobacter freundii, Morganella morganii, Proteus vulgaris, Providencia rettgeri, Providcncia stuartii, Serratia marcescens, Clostridium perfringens.
Pharmokinetics Eleflox:
When taken orally Eleflox, it is absorbed from the digestive tract quickly and almost completely. Eating little effect on the speed and completeness of absorption. Bioavailability is 99%. Cmax is reached after 1-2 hours and when taken with 250 mg and 500 mg is 2.8 and 5.2 μg / ml, respectively. Binding to plasma proteins - 30-40%. It penetrates well into organs and tissues: lungs, mucous membrane of the bronchi, sputum, organs of the genitourinary system, polymorphonuclear leukocytes, alveolar macrophages. In the liver, a small portion is oxidized and / or deacetylated. Renal clearance is 70% of the total clearance.
T1 / 2 - 6-8 hours. It is excreted mainly by the kidneys by glomerular filtration and tubular secretion. Less than 5% of levofloxacin is excreted as metabolites. In unchanged form, with urine within 24 hours, 70% is excreted and in 48 hours - 87%; in feces for 72 hours, 4% of the oral dose is found. After iv infusion of 500 mg for 60 min Cmax - 6.2 μg / ml. When iv is Eleflox administered once and repeatedly, the apparent Vd after administration of the same dose is 89-112 L, Cmax - 6.2 μg / ml, T1 / 2 - 6.4 hours.
Indications Eleflox:
Helps with Eleflox Infections of the lower respiratory tract (chronic bronchitis, pneumonia), ENT organs (sinusitis, otitis media), urinary tract and kidneys (including acute pyelonephritis), genital organs (including urogenital chlamydia), skin and soft tissues (festering atheroma, abscess, boils).
Contraindications Eleflox:
Hypersensitivity, epilepsy, tendon damage with previous treatment with quinolones, pregnancy, lactation, children and adolescents under 18 years of age.
Side effects Eleflox:
From the digestive system: nausea, vomiting, diarrhea, anorexia, abdominal pain, pseudomembranous enterocolitis, increased activity of "hepatic" transaminases, hyperbilirubinemia, hepatitis, dysbiosis.
From the cardiovascular system: lowering blood pressure, vascular collapse, tachycardia.
From the side of metabolism: hypoglycemia (increased appetite, sweating, trembling).
From the side of the central nervous system and peripheral nervous system: headache, dizziness, weakness, drowsiness, insomnia, paresthesia, anxiety, fear, hallucinations, confusion, depression, motor disorders, cramps.
From the sensory organs: impaired vision, hearing, smell, taste and tactile sensitivity.
From the musculoskeletal system: arthralgia, myalgia, tendon rupture, muscle weakness, tendonitis.
From the urinary system: hypercreatininemia, interstitial nephritis.
From the hemopoietic system: eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemorrhage. levofloxacin
Dermatological reactions for levofloxacin, Eleflox photosensitivity, pruritus, swelling of the skin and mucous membranes, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
Allergic reactions for levofloxacin, urticaria, bronchospasm, suffocation, anaphylactic shock, allergic pneumonitis, vasculitis.
Other: exacerbation of porphyria, rhabdomyolysis, persistent fever, the development of superinfection.
Ways of application Eleflox:
Inside, before meals or in between meals, without chewing, drinking plenty of fluids. I / O, slowly. With sinusitis - inside, 500 mg 1 time /; with exacerbation of chronic bronchitis - 250-500 mg 1 time / With pneumonia - by mouthto accept Eleflox, 250-500 mg 1-2 (500-1000 mg /); in / in - 500 mg 1-2 In case of urinary tract infections - inside, 250 mg 1 time / or iv in the same dose. For infections of the skin and soft tissues - 250-500 mg orally 1-2 or iv, 500 mg 2 After iv administration a few days later, it is possible to switch to oral administration in the same dose.
In case of kidney diseases to accept Eleflox, the dose is reduced in accordance with the degree of dysfunction: with KK = 20-50 ml / min - 125-250 mg 1-2, with KK = 10-19 ml / min - 125 mg 1 time in 12-48 hours , with CC <10 ml / min - 125 mg after 24 or 48 hours. Duration of treatment is 7-10 (up to 14) days.
