Instructions for Elzhina (Econazole, Ornidazole) vaginal tablets
Elzhina is an antimicrobial combined preparation for intravaginal use.
Release form and composition Elzhina:
is an antimicrobial combined preparation for intravaginal use. Release form and composition Elzhina is produced in the form of vaginal tablets: oblong, flat, beveled, white with a yellow tinge or white, marbling is possible (3 pieces in a blister strip, 1, 2 or 3 packages in a cardboard box). Composition of 1 vaginal tablet: active ingredients: neomycin (in the form of sulfate) - 65,000 international units (IU), ornidazole - 500 mg, econazole (in the form of nitrate) - 100 mg, prednisolone (in the form of sodium phosphate) - 3 mg; additional components: potato starch, lactose monohydrate, crospovidone, povidone (low molecular weight polyvinylpyrrolidone), talc, colloidal silicon dioxide, calcium stearate, polysorbate 20.
Pharmacodynamics Elzhina:
is a combined antibacterial, antifungal, anti-inflammatory, antiprotozoal and antipruritic agent for local use in gynecology. The effect of the drug Elzhina is due to the properties of its active ingredients: neomycin: a broad-spectrum antibiotic belonging to the aminoglycoside group; is active against a number of gram-positive and gram-negative aerobic microorganisms, the resistance of which to neomycin is formed slowly and to an insignificant extent; almost not absorbed through the mucous membranes; ornidazole: antiprotozoal drug, antimicrobial action; effective against Giardia lamblia (Giardia intestinalis), Entamoeba histolytica, Trichomonas vaginalis, some anaerobic bacteria, including Fusobacterium spp., Clostridium spp., Bacteroides spp., as well as anaerobic cocci -
Peptostreptococcus spp the mechanism of action is associated with the suppression of synthesis and damage to the structure of the DNA of pathogens; prednisolone: a glucocorticosteroid, a dehydrated analog of hydrocortisone; has antiallergic, antipruritic and anti-inflammatory effect; quickly relieves burning and itching; econazole: demonstrates antifungal action against yeast and yeast-like fungi of the genus Candida, dermatophytes Epidermophyton spp.,
Microsporum spp. and Trichophyton spp. in combination with antibacterial effect against gram-positive bacteria Streptococcus spp. and Staphylococcus spp .; the mechanism of action is due to the suppression of the synthesis of ergosterol, which is a component of the fungal cell membrane; possesses bactericidal and fungicidal properties. Elzhina prevents the formation, release and manifestation of the activity of inflammatory mediators, such as prostaglandins, kinin, histamine, lysosomal enzymes. The drug Elzhina blocks the migration of cells to the site of inflammation, reduces vasodilation and increased vascular permeability in the lesion. Due to its vasoconstrictor effect, it reduces exudation.
Pharmacokinetics Elzhina:
With intravaginal administration, there is a slight systemic absorption of the active substances of the drug Elzhina. The agent is almost not absorbed from the surface of the vaginal mucosa. Indications for use bacterial vaginitis, excited by the banal pyogenic flora; vulvovaginitis due to fungi of the genus Candida; vaginitis caused by mixed infection.
Contraindications Elzhina:
Absolute: age under 18; hematopoietic disorders; organic diseases of the central nervous system (CNS); pregnancy and lactation; hypersensitivity to any of the components that make up the product. Relative (use the drug Elzhina with caution): alcoholism; functional disorders of the liver. Instructions for the use of Elzhina: method and dosage Elzhin's tablets are used intravaginally. It is recommended to use 1 tablet daily at bedtime. Lying on your back, the drug Elzhina should be injected deep into the vagina after hygienic treatment of the external genitalia.
Before administration, the tablet should be held for 20-30 seconds in cold boiled water. After the procedure, it is required to be in the supine position for another 10-15 minutes. The course can be on average 6-9 days. During menstrual bleeding, Elzhina should be used as usual. If, after a course of drug Elzhina therapy, there is no improvement in the condition or new symptoms of the disease appear, you should consult your doctor. Side effects skin and subcutaneous tissues: skin peeling, contact dermatitis, erythema, urticaria, angioedema; general disorders and reactions at the injection site: vaginal dryness (mainly at the beginning of the course), irritation, pain, burning and swelling at the injection site. With the development of any other disorders or aggravation of the severity of the above reactions, it is required to consult a doctor.
Overdose Elzhina:
Against the background of intravaginal administration of the drug Elzhina, an overdose is unlikely. In case of unintentional oral administration of the drug, symptoms of intoxication may be: diarrhea, vomiting, nausea, tremors, dizziness, convulsions, headache, loss of consciousness. Treatment is symptomatic. special instructions Elzhina tablets are intended exclusively for intravaginal use.
Despite the fact that in the course of clinical studies no undesirable effects on the part of the hematopoietic system were found, the drug Elzhina is contraindicated for existing diseases of the hematopoietic system, including hematopoietic disorders and leukemia (including a history). In order to reduce the threat of recurrence of the disease, it is recommended to carry out simultaneous therapy of sexual partners. In the presence of diseases of the central nervous system, the drug should be used with caution.
During the course of treatment, it is required to refrain from sexual intercourse. During therapy, cross-allergization and resistance to aminoglycosides may occur. Discontinue use of the drug Elzhina if severe irritation occurs. It is not recommended to use tablets for more than 9 days. Influence on the ability to drive vehicles and complex mechanisms According to the instructions, Elzhina does not affect the patient's ability to drive potentially dangerous and complex machinery, including vehicles.
Elzhina
