Instructions for Euphylline (Aminophylline) solution
English product name
p-r d/v/v of 24 mg/ml: 5 ml or 10 ml amp. 5 or 10 pcs
Solution for in/in administration in the form of a colourless or slightly coloured transparent liquid.
aminophylline 24 mg
Auxiliary substances: water up to 1 ml
Clinical-pharmacological groups / Group affiliation
Broncholytic preparation - phosphodiesterase inhibitor
Pharmacotherapy group Euphylline
Bronchodilating agent - phosphodiesterase inhibitor
Pharmacological effect Euphylline:
Broncholytic agent, PDE inhibitor. It is the ethylenediamine salt of theophylline (which facilitates solubility and increases absorption). It has bronchial augmentation, apparently caused by a direct relaxing effect on the smooth muscles of the airways and blood vessels of the lungs.
- For parenteral use:
- asthmatic status (additional therapy),
- newborn apnea,
- ischemic type cerebral circulation disorder (in combination therapy),
- left-ventricular insufficiency with bronchospasm and Cheyne-Stokes type breathing disorder, renal syndrome (in complex
- therapy); acute and chronic heart failure (as part of combination therapy).
- To receive inside: Bronchosoobstructive syndrome of various origins (including bronchial asthma,
- COPD including pulmonary emphysema,
- chronic obstructive bronchitis),
- hypertension in the small circulatory circle,
- pulmonary heart,
- night apnea;
- acute and chronic heart failure (as part of combination therapy).
How to Take, Course of Intake and Dosage Euphylline:
Euphylline is administered intramuscularly, deep into the upper quadrant of the gluteal muscle at one ml (two hundred and forty mg) of solution.
Euphylline is parenterally administered up to three times a day, up to fourteen days.
The concentration of eufillin in the blood serum should not exceed twenty ug/ml.
The highest doses of eufillin for adults intramuscularly: single - 0.5 g, daily - 1.5 g. Higher doses for children intramuscularly: one-time - 7 mg/kg, daily - fifteen mg/kg.
Correction of dosing regime may be required in case of heart failure, liver function disorders, chronic alcoholism. In older patients, a dose reduction (0.3 g single dose) may be required. Smoking patients are advised to increase the dose due to accelerated withdrawal of the drug from the body (single dose - 0.7 g).
- Nosology Euphylline (ICD codes)
- Sleep apnea (respiratory center disorders)
- Primary pulmonary hypertension
- Other secondary pulmonary hypertension
- Other refined forms of pulmonary heart failure
- Pulmonary heart failure unspecified (including pulmonary heart [cor pulmonale] (chronic) BDU)
- Congestive heart failure
- Left ventricular failure
- Brain infarction
- Other chronic obstructive pulmonary disease
- Asthmatic status [status asthmaticus]
- Nephrotic syndrome
- Primary apnea during sleep in a newborn
- Other types of apnea in a newborn