Fluconazole capsules
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Fluconazole capsules

SKU:2178
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Fluconazole capsules antifungal agent, has high specificity for fungal enzymes
Active substance:Fluconazole
Pharmacological group:Antifungal
Formulation:Capsules
Country of origin:Russia
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Instructions for Fluconazole capsules

Fluconazole capsules

Description
Solid gelatine capsules № 1 with blue body and cap.
The capsule contents are white or white powder with a yellowish color.

Active substances
Fluconazole
Composition
Per capsule:

Active substance:
Fluconazole - 150,000 mg,
auxiliary substances: lactose monohydrate, cornstarch, magnesium stearate, silicon dioxide colloidal (aerosyl), sodium lauryl sulfate

Pharmacological effect Fluconazole:

Antifungal preparations for systemic use. Triazole derivatives
Fluconazole, a triazole antifungal agent, is a potent selective inhibitor of sterol synthesis in the fungal cell.

Its main mechanism of action is to inhibit the 14-alpha-lanosterol demethylation reaction mediated by fungal cytochrome P450, which is a key step in ergosterol biosynthesis in fungi. The accumulation of 14-alpha-methylsterols correlates with the subsequent loss of ergosterol, which is part of the cell membrane of fungi, and this process may be at the heart of the antifungal action of fluconazole. Fluconazole is shown to be more selective with respect to cytochrome P450 fungi than with respect to various cytochrome P450 mammalian enzymes.

Testimony Fluconazole:

  • Fluconazole is indicated for the following diseases treated in adults:
  • cryptococcal meningitis,
  • coccidioidomycosis,
  • invasive candidiasis,
  • mucous candidiasis, including oropharyngeal candidiasis, esophageal candidiasis, candiduria and chronic cutaneous
  • candidiasis,
  • chronic atrophic oral candidiasis (associated with dental prostheses) when oral hygiene or local treatment is not
  • sufficient,
  • vaginal candidiasis, acute or recurrent, when local therapy is not applicable,
  • Candida balanitis, when local therapy is not applicable,
  • dermatomycosis, including stop dermatophytia, torso dermatophytia, inguinal dermatophytia, multicoloured lychee and
  • cutaneous candidiasis when systemic treatment is shown,
  • Nail dermatophilia (onychomycosis), when treatment with other drugs is not acceptable.
  • Fluconazole is indicated for the prevention of the following diseases in adults:
  • Relapse of cryptococcal meningitis in patients at high risk of relapse,
  • Relapse of oropharyngeal candidiasis and esophageal candidiasis in HIV-infected patients at high risk of relapse,
  • to reduce the frequency of vaginal candidiasis recurrences (4 or more episodes per year),
  • for the prophylaxis of candidal infections in patients with long-term neutropenia (such as patients with haemoblastosis
  • undergoing chemotherapy or patients undergoing hematopoietic stem cell transplantation).
  • Fluconazole is indicated for the treatment of children:
  • Fluconazole is used to treat mucous candidiasis (oropharyngeal candidiasis and esophageal candidiasis), invasive
  • candidiasis, cryptococcal meningitis and to prevent candida infections in patients with weakened immune systems.
  • Fluconazole can be used as a maintenance therapy to prevent the recurrence of cryptococcal meningitis in children at high
  • risk of relapse.

Pharmacotherapy group:

Antifungal agent

Use in children
It is used in children in special medical forms.

  • Nosology Fluconazole (ICD codes)
  • B20.5
  • HIV-related illness with other mycoses
  • B35.0
  • Mikoz beards and heads
  • B35.1
  • Nail mycosis
  • B35.2
  • Mikoz brushes
  • B35.3
  • Mycosis stop
  • B35.4
  • Torso mycosis
  • B35.6
  • Epidermofitia
  • B36.0
  • Multicolored fox
  • B37.0
  • Candidiasis stomatitis
  • B37.1
  • Pulmonary candidiasis
  • B37.2
  • Skin and nail candidiasis
  • B37.3
  • Candidiasis vulva and vagina
  • B37.4
  • Candidiasis of other urogenital localizations
  • B37.5
  • Candidiasis meningitis
  • B37.6
  • Candida endocarditis
  • B37.7
  • Candidiasis sepsis
  • B37.8
  • Candidiasis of other localizations (including candidiasis enteritis)
  • B38
  • Coccidioidomycosis
  • B39
  • Histoplasmosis
  • B41
  • Paracocydiidomycosis
  • B42
  • Sporotrichosus
  • B45
  • Cryptococcosis
  • N51.2
  • Balanite for diseases classified in other headings
  • N77.1
  • Vaginitis, vulvite and vulvovaginitis for infectious and parasitic diseases classified in other headings
  • Z29.8
  • Other specific preventive measures
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