Instructions for Furosemide bufus solution 10 ampoules
English product name
10 mg/ml injection r-d/v/v and v/m: 2 ml amp. 10 pcs.
Solution for in/in and in/m administration in the form of transparent, colourless or with a yellowish tint of liquid.
furosemide 10 mg
Auxiliary substances: sodium chloride - 7.5 mg, sodium hydroxide - 1.28 mg, sodium hydroxide solution 1M - up to pH 8.0-9.3, water d/i - up to 1 ml.
"Loop" diuretic. Disrupts the reabsorption of sodium ions, chlorine in the thick segment upstream of the Genle loop. As a result of an increase in the release of sodium ions, a secondary (mediated by osmotically connected water) increased water removal and an increase in the secretion of potassium ions in the distal part of the renal channel occurs. At the same time, the extraction of calcium and magnesium ions increases.
After ingestion, absorption is 60-70%. In severe kidney disease or chronic heart failure, absorption is reduced.
Vd is 0.1 l/kg. Binding to plasma proteins (mainly albumin) is 95-99%. It is metabolized in the liver. It is excreted by the kidneys - 88%, with bile - 12%. T1/2 in patients with normal kidney and liver function is 0.5-1.5 h. In anuria, T1/2 may increase to 1.5-2.5 h, in combination renal and liver failure - to 11-20 h.
Method of use, course and dosage
Set individually, depending on the indications, clinical situation, age of the patient. During treatment, the dosing regime is adjusted according to the size of the diuretic response and the dynamics of the patient's condition.
When ingested, the initial dose for adults is 20-80 mg/day, then the dose is gradually increased to 600 mg/day if necessary. For children, the single dose is one to two mg/kg.
- Nosology (ICD codes)
- Calcium metabolism disorders
- Swelling of the brain
- Essential [primary] hypertension
- Congestive heart failure
- Left ventricular failure
- Pulmonary edema
- Fibrosis and cirrhosis
- Nephrotic syndrome