indications for Heptral (Ademetionine)
Briefly about the product Heptral:
Heptral® is a source of active amino acid that starts the process of natural regeneration of liver cells from the inside:
Restoration of the structure of liver cells.
Removal of toxins.
Excretion of bile acids.
Replenishment of the energy potential of cells.
Regeneration of liver cells.
Heptral® helps to improve well-being and liver functions after the 1st week of administration.
The effect of taking Heptral® can persist for 3 months after the end of treatment.
Taking Heptral® 400 mg tablets is possible once a day.
Structure Heptral:
Each tablet contains
Active ingredient Heptral:
Ademetionine (active ingredient dosage: 400 mg)
Excipients: colloidal silicon dioxide - 4.4 mg, microcrystalline cellulose - 93.6 mg, sodium carboxymethyl starch (type A) - 17.6 mg, magnesium stearate - 4.4 mg;
Tablet shell: methacrylic acid and ethyl acrylate copolymer (1: 1) - 27.6 mg, macrogol-6000 - 8.07 mg, polysorbate-80 - 0.44 mg, simethicone (emulsion 30%) - 0.13 mg, sodium hydroxide - 0.36 mg, talc - 18.4 mg, water - QS
pharmachologic effect
Ademetionine belongs to the group of hepatoprotectors, and also has antidepressant activity. It has choleretic and cholekinetic effects, has detoxifying, regenerating, antioxidant, anti-fibrosing and neuroprotective properties.
Replenishes the deficiency of S-adenosyl-L-methionine (ademetionine) and stimulates its production in the body, is contained in all environments of the body. The highest concentration of ademetionine was found in the liver and brain. Plays a key role in the metabolic processes of the body, takes part in important biochemical reactions: transmethylation, transsulfurization, transamination.
Side effects Heptral:
From the digestive system: often - nausea, abdominal pain, diarrhea; rarely - vomiting, dry mouth, esophagitis, dyspepsia, flatulence, gastrointestinal pain, gastrointestinal bleeding, hepatic colic.
From the nervous system: rarely - confusion, insomnia, dizziness, headache, paresthesia.
From the musculoskeletal system: rarely - arthralgia, muscle cramps.
From the urinary system: rarely - urinary tract infections.
From the side of the skin: rarely - hyperhidrosis, itching, skin rash.
Local reactions: rarely - reactions at the injection site; very rarely - reactions at the injection site, skin necrosis at the injection site.
Allergic reactions: rarely - anaphylactic reactions; very rarely - Quincke's edema, laryngeal edema.
Others: rarely - hot flashes, superficial phlebitis, asthenia, chills, flu-like symptoms, weakness, peripheral edema, hyperthermia.
Indications for use Heptral (Ademetionine):
• intrahepatic cholestasis in pre-cirrhotic and cirrhotic conditions, which can be observed in the following diseases:
• fatty degeneration of the liver;
• chronic hepatitis;
• toxic liver damage of various etiologies, including alcoholic, viral, medicinal (antibiotics, anticancer, anti-tuberculosis and antiviral drugs, tricyclic antidepressants, oral contraceptives);
• chronic acalculous cholecystitis;
• cholangitis;
• cirrhosis of the liver;
• encephalopathy, incl. associated with liver failure (including alcoholic);
• intrahepatic cholestasis in pregnant women;
• symptoms of depression;
• increased fatigue in chronic liver diseases.
How to take, course and dosage Heptral:
The recommended dose is 10-25 mg ademetionine per 1 kg of body weight per day. Typically, the daily dose is 1-2 tablets per day (from 400-800 mg ademetionine per day) and can be increased to 4 tablets per day (up to 1600 mg ademetionine per day).
Tablets Heptral ® 400 mg should be taken whole, without chewing, preferably in the morning between meals. Geptral Tablets ® 400 mg should be removed from the blister immediately before ingestion, as ademetionine acting Geptral component ® , sensitive to light.
Age of application: from 18 years old
