Instructions for Macmiror Complex (Nystatin, Nifuratel) vaginal cream 30 gr
English product name
Macmiror Complex
Release form
Vaginal cream 100 mg + 40 thous. ME/1 g: 30 g tube with applicator (1 pc.)
Description Macmiror Complex:
The cream is liquid, homogeneous and yellow.
100g
- Nifuratel 10g
- nistatin 4 million ME
- Auxiliary substances:
- xalifin 15 10 g,
- methylparahydroxybenzoate 0.11 g,
- propyl parahydroxybenzoate 0.04 g,
- glycerol (glycerin) 5 g,
- sorbitol 70% solution 10 g,
- propylene glycol 5 g,
- carbomer 0.4 g,
- triethanolamine 30% 1.5 g,
- water purified up to 100 g.
30 g - aluminium tubes (1) complete with applicator (graduated syringe) - cardboard packs.
ATC codes
G01AX Other antiseptics and antimicrobials for the treatment of gynaecological diseases
Clinical and pharmacological groups / Group affiliation
Antibacterial, antibacterial and antifungal agent for topical use in gynaecology
Active substance
Nystatin
Nifuratel
Pharmacotherapeutic group Macmiror Complex:
Antimicrobial combined agent (antimicrobial and antiskid agent+antifungal agent)
Indications Nifuratel:
- Vulvovaginal infections caused by drug-sensitive pathogens: including
- bacterial vaginitis, vaginal trichomoniasis;
- vaginitis,
- caused by Candida fungi,
- mixed vaginites.
Method of use, course and dosage:
Intravaginally. The frequency of use depends on the dosage form used.
Applied within 8 days or according to the doctor's recommendations. If necessary, treatment can be repeated after menstruation.
Contraindications to application
Child age (for use in the form of suppositories); increased sensitivity to the components of the combined drug Macmiror Complex.
Special Instructions Nifuratel:
The sexual partner must be treated at the same time because of the risk of re-infection. Sexual contact should be avoided during treatment.
Use in children
It is not used in the form of suppositories.
- Nosology (ICD codes)
- A59
- Trichomoniasis
- B37.3
- Candidiasis vulva and vagina
- N76
- Other inflammatory diseases of the vagina and vulva
- N77.1
- Vaginitis, vulvite and vulvovaginitis for infectious and parasitic diseases classified in other headings
Pharmacological effect Macmiror Complex:
Antimicrobial agent for local use. It has antiplatozoic, antifungal and antibacterial effects.
Nifuratel, a derivative of nitrofuran, is highly active against a number of bacteria, fungi and protozoa (including Trichomonas vaginalis).
Nystatin is an antifungal antibiotic of a group of polyenes. By binding to sterols in the cell membrane of fungi, it disrupts its permeability, leading to cell death. It is highly active in Candida albicans.
The combination of Nifuratel and nystatin allows achieving a more pronounced antifungal action and significantly expanding the spectrum of antimicrobial action.
The high effectiveness and low toxicity of the components of the preparation determine a wide range of the clinical use thereof in the treatment of mixed-etiology vaginitis, in particular the use thereof for the prophylaxis of mycosis caused by the specific treatment of trichomoniasis.
It does not disturb the physiological flora, which allows to avoid the development of dysbacteriosis and to quickly restore the normocenosis of the vagina.
