Instructions for Milgamma Compositum (Pyridoxine, Benfotiamine)
Active substance:
benphotiaminpiridoxin
Release Form
wrapped pills
Owner/Registrar
WOERWAG PHARMA, GmbH & Co. KG
Indications
Tightening fox with other complications from the nervous system
G50.0
Neuralgia triple nerve
G51
Facial nerve damage
G54
Nervous spine and gossip lesions
G60
Hereditary and idiopathic neuropathy
G61
Inflammatory Polyeuropathy
G62.1
Alcohol Polyeuropa
G63.2
Diabetic Polyeuropathy (E10-E14+ with common fourth sign .4)
H46
Neuritus optic nerve
M42
Osteochondrosis of the spine
M54.1
Radiculopathy
M54.3
Ishias
M54.4
Lumbago with Ishias
M79.2
Neuralgia and Neuritius Unspecified
R25.2
Spasms
Pharmaceutical Group:
B vitamin complex
Pharmaceuticals:
Combined vitamin preparation.
Benfotiamine, a fat-soluble derivative of tiamine (vitamin B1), is phosphoryl in the body to biologically active compositions of thiamine diphosphate and thiamine triphosphate. Tiamine diphosphate is a copier of piruvatcarboxylase, 2-occiglutaratdehydrogenase and transcetolase, thus participating in the pentosophosphate cycle of oci glucose blends (in aldehyde group transfer).
Phosphorylated form of pyridoxine (vitamin B6) - pyridoxalphosphate - is a coffer of a number of enzymes affecting all stages of nonoxidative metabolism of amino acids. Piridoxalphosphate is involved in the process of decarboxylation of amino acids, and therefore in the formation of physiologically active amines (e.g. adrenaline, serotonin, dopamine, tiramin). By participating in the transaminization of amino acids, pyridoxalphosphate is involved in anabolic and catabolic processes (for example, being a coffer of transaminaz such as glutamat-oxalotz transaminase, glutamate-piruvat-transaminase, gamma-amino-butyroic acid (GABA), α-ketoglutarat-transaminase), and various reactions disintegration and synthesis of amino acids. Vitamin B6 is involved in 4 different stages of tryptofan metabolism.
Pharmacokinetics:
Intake and distribution
When taken inside, most benphothiamine is absorbed in the duodenal intestine, the smaller part is absorbed in the upper and middle departments of the small intestine. Benfotiamine is absorbed by active resorption at the concentrations ≤2 umol and by passive diffusion at concentrations ≥2 umol. As a fat-soluble derivative of tiamine (vitamin B1), benphothiamine is absorbed faster and more fully than water-soluble tiamine hydrochloride. In the intestine, benphotiamine is converted into S-benzoiltiamine as a result of disphosphoryl by phosphate. S-benzoiltiamine is fat-soluble, has a high penetrating capacity and is absorbed, mainly without turning into tiamine. Due to enzymatic debenzoylation after absorption, thiamine and biologically active coferments of tiamine diphosphate and tiamine triphosphate are formed. Especially high levels of these conferments are observed in the blood, liver, kidneys, muscles and brain.
Piridoxine Milgamma (vitamin B6) and its derivatives are absorbed mainly in the upper LCT departments during passive diffusion. In the blood serum, pyridoxalphosphate and pyridoxal are associated with albumin. Before penetration through the cell membrane of the pyridoxalphosphate associated with albumine is hydrolyzed by alkal phosphatase with the formation of pyridoxal.
Metabolism and Disposal:
Both vitamins are produced mainly with urine. About 50% of tiamine is produced in the same form or as sulfate. The remaining part consists of several metabolites, including tiamine acid, methylthiazo-acetic acid and pyramiene. The average T1/2 of benphothiamine blood is 3.6 hours.
T1/2 pyridoxine at intake is about 2-5 hours. Biologic T1/2 tiamine and pyridoxine is about 2 weeks.