Noliprel a Forte (Indapamide, Perindopril) 1,25 mg + 5 mg

Noliprel a Forte (Indapamide, Perindopril) 1,25 mg + 5 mg

SKU:2170
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Noliprel a Forte combined drug, decreased filling pressure in the left and right ventricles of the heart, essential hypertension
Active substance:Indapamide, Perindopril
Pharmacological group:Cardiovascular
Formulation:Tablets
Dosage mg:1.25
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$42
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Instructions for Noliprel a Forte (Indapamide, Perindopril) 1,25 mg + 5 mg

English product name
Noliprel® A forte

Release form
tabbed film coating, 1.25 mg+5 mg: 14, 29, 30 or 90 pcs
tabbed film coating, 1.25 mg+5 mg: 14, 30 or 90 pcs
Description
The tablets are covered with film sheath, white in color, oblong.

1 tab.
indapamide 1.25 mg
perindoprila arginine 5 mg,
which corresponds to perindopriva content 3.395 mg
Auxiliary substances: lactose monohydrate, magnesium stearate, maltodextrin, silicon dioxide colloidal anhydrous, carboxymethyl sodium starch (type A).

Film sheath composition: macrogol 6000, premix for the white film shell SEPIFILM 37781 RBC (glycerol, hypromellose, macrogol 6000, magnesium stearate, titanium dioxide (E171)).

14 pcs. - polypropylene bottles with a dosator and a stopper containing a moisture-absorbing gel (1) - cardboard packs with the control of the first opening.
29 pcs. - polypropylene bottles with a dosator and a stopper containing a moisture-absorbing gel (1) - cardboard packs with the control of the first opening.
30 pcs - polypropylene bottles with a dosator and a stopper containing a moisture-absorbing gel (1) - cardboard packs with the control of the first opening.

Packages for stationary:
30 pcs - polypropylene bottles with a dosator and a stopper containing a moisture-absorbing gel (3) - cardboard packs with the control of the first opening.

ATC codes
C09BA04 Perindopril in combination with diuretics

Clinical-pharmacological groups / Group affiliation
Hypotensive combination drug (ACE inhibitor and diuretic)

Active substance

  • indapamide
  • perindopril (in the form of arginine perindopril)

Pharmacotherapy group Noliprel a Forte:

Hypotensive combined agent (diuretic+ACE inhibitor)

Storage Conditions
The drug should be stored in a place inaccessible to children at a temperature not higher than 30 ° C.

Best before date
The shelf life is three years. Do not apply after the expiry date indicated on the package.

Pharmacological effect Noliprel a Forte:

The medicinal preparation Noliprel® A forte is a combined preparation containing indapamide and perindopril arginine. The pharmacological properties of the Noliprel® drug Forte combine the individual properties of each component.

Mechanism of action
Noliprel® A fort
The combination of perindopril and indapamide enhances the antihypertensive effect of each.

Indapamide
Indapamide belongs to the sulfonamide group, and is pharmacologically close to the thiazide diuretics. Indapamide inhibits the reabsorption of sodium ions in the cortical segment of the Genle loop, which leads to an increase in the removal of sodium, chlorine and, to a lesser extent, potassium and magnesium ions by the kidneys, thereby enhancing diuresis and reducing AD.

Perindopril
Perindopril is an inhibitor of the enzyme that converts angiotensin I to angiotensin II (ACE inhibitor). ACE, or kininase II, is an exopeptidase that performs both the conversion of angiotensin I into the vasoconstrictive substance angiotensin II and the destruction of bradykinin, which has a vasodilating effect, to an inactive heptapeptide. As a result, perindopril reduces the secretion of aldosterone; by the principle of negative feedback increases renin activity in blood plasma;

Testimony Noliprel a Forte:

  • essential hypertension;
  • In patients with arterial hypertension and type 2 diabetes to reduce the risk of developing microvascular complications (from the kidneys) and macrovascular complications from cardiovascular disease.
  • Method of use, course and dosage
  • It is used in the morning, preferably before meals.

Essential hypertension
Prescribed one tabb. drug Noliprel® and forte once a day
If possible, the administration of the preparation begins with the selection of doses of single-component drugs. In case of clinical necessity, it is possible to consider a combination therapy with Noliprel® A forte immediately after monotherapy.
Patients with arterial hypertension and type 2 diabetes to reduce the risk of microvascular complications (from the kidneys) and macrovascular complications from cardiovascular disease
It is recommended to start therapy with a combination of perindopril/indapamide at a dose of 2.5 mg/0.625 mg (Noliprel® A drug) once a day. After three months of therapy, if well tolerated, it is possible to increase the dose - one tablet. Noliprel® And forte once a day.

Use in children
Use in children and adolescents under the age of 18 is contraindicated.

  • Nosology Noliprel a Forte (ICD codes)
  • I10
  • Essential [primary] hypertension
  • N08.3
  • Glomerular Diabetes Lesions
  • N08.8
  • Glomerular lesions for other diseases classified in other headings
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