Instructions for Oftarint (nicotinamide, cytochrome c, adenosine) eye drops 10 ml
ATC Codes
S01XA Other drugs for eye disorders
group affiliation
Drug for cataracts
Active substance
- nicotinamide
- cytochrome C
- adenosine
Pharmacotherapeutic group Oftarint
Tissue Repair Stimulant
Shelf life
Shelf life is three years. One month after opening the vial. Do not apply after expiration date.
Pharmacological effect Oftarint
A combined drug that improves the energy metabolism of the lens.
Indications
Eye drops are used for cataracts.
Senile cataracts in older people
Method of use, course and dosage of eye drops
Locally, one to two drops into the conjunctival sac three times/day.
- Nosology (ICD codes)
- H25
- Senile cataract
- H26
- Other cataracts
The pharmacological effect describes a combined drug that improves the energy metabolism of the lens.
Main components and their action Oftarint:
Cytochrome C:
It plays an important role in the redox processes in the eye tissues.
It has antioxidant properties.
It is a precursor of ATP and is actively involved in the metabolic processes of the lens.
It penetrates the cornea well.
Stimulates the synthesis of nicotinamide dinucleotide, which is a cofactor for various dehydrogenases.
Pharmacokinetics Oftarint:
Suction and distribution:
Topical cytochrome C does not enter the systemic circulation.
Adenosine penetrates the cornea.
Metabolism and elimination:
Cytochrome C is metabolized as an amino acid, and heme is converted to bilirubin and eliminated in bile.
Adenosine is metabolized in all tissues, forming inosine, xanthine, and urate, which are excreted in urine. Ribose is metabolized to glyceraldehyde-3-phosphate, pyruvate, and further involved in the Krebs cycle. The half-life of adenosine from plasma is less than 1 minute.
Nicotinamide is partly metabolized to nicotinic acid and methylated to N-methylnicotinamide, which is broken down in the liver. Unmodified nicotinamide and its metabolites are excreted in the urine.
Thus, said medicinal agent acts on the level of cellular metabolism in the eye tissues, improving the energy processes thereof and protecting against oxidative stress.