Release form and composition:
Dosage form - tablets: round flat-cylindrical shape, with a chamfer and a dividing line (10 pcs. In a blister or non-bladder packaging, in a cardboard box 1, 2, 3 or 6 packages; 20 pcs. In a polymer bottle, in a cardboard box 1 bottle) ... The active substance is potassium orotate, in 1 tablet - 500 mg. Auxiliary components: potato starch, lactose, stearic acid, medical gelatin.
pharmachologic effect:
The drug is a potassium salt of orotic acid. Orotic acid is one of the precursors of pyrimidine nucleotides that are part of nucleic acids that are involved in the synthesis of protein molecules, and therefore salts of orotic acid are considered as substances of anabolic action and are used for disorders of protein metabolism to stimulate them.
Potassium orotate stimulates the synthesis of nucleic acids, the production of albumin in the liver, especially in conditions of prolonged hypoxia (oxygen deficiency), increases appetite, has diuretic (diuretic) and regenerative properties.
Pharmacokinetics:
After oral administration, 10% of the dose taken orally is absorbed (absorbed) in the gastrointestinal tract. In the liver, it is converted into orotidine-5-phosphate. It is excreted by the kidneys (30% as metabolites).
Special conditions:
During the period of treatment, it is advisable to follow a diet.
The effect of the drug on the ability to drive vehicles and mechanisms:
The drug does not cause drowsiness and a decrease in the speed of psychomotor reactions
Indications:
for use According to the instructions,
Potassium orotate is used as part of the combined treatment of the following diseases:
- Chronic heart failure stage II and III;
- Myocardial infarction;
- Heart rhythm disturbances (especially with atrial fibrillation and extrasystole);
- Diseases of the biliary tract and liver caused by intoxication (except for ascites in cirrhosis);
- Dermatoses;
- Alimentary and alimentary-infectious malnutrition in children;
- Progressive muscular dystrophy.
- In addition, the drug is prescribed to patients during the period of convalescence, with increased physical exertion.
Side effects:
Potassium orotate is generally well tolerated.
In some cases, allergic skin reactions may occur, which disappear after interruption of treatment.
Potassium orotate can also cause mild indigestion (nausea, vomiting, diarrhea). When used in high doses against the background of a low-protein diet, the development of liver dystrophy is possible.
How to take, course and dosage:
Should be taken orally 1 hour before meals or 4 hours after meals.
Adults 250-500 mg 2-3 times a day. The course of treatment lasts an average of 20-30 days. If necessary, the treatment can be repeated after 1 month.
In exceptional cases, you can increase the dose of adults up to 3 g per day.
Children - 10-20 mg / kg of body weight per day, divided into 3-4 doses (for example, if the child's body weight is 25 kg, then the permitted dose is from 25 x 10 = 250 mg (1/2 table) to 25 x 20 = 500 mg (1 table) per day, divided into 3-4 doses). The course of treatment is 3-5 weeks.
