Active substance Pyrantel:
pyrantel
International Classification of Diseases (ICD-10) B76
Ankylostomiasis B76.1
Necatorosis B77
Ascariasis B79
Trichuroz
Pharmacological group Pyrantel:
Anthelmintic drug
pharmachologic effect Pyrantel:
Anthelmintic agent. It causes neuromuscular blockade of sensitive helminths. It is active against Enterobius vermicularis, Ancylostoma duodenale, Necator americanus and, to a lesser extent, Trichocephalus trichiurus. Acts on both sexually mature and immature individuals of both sexes.
Pharmacokinetics
Practically not absorbed from the gastrointestinal tract. After taking a single dose of 10 mg / kg, the plasma concentration is 0.005-0.13 μg / ml and is reached within 1-3 hours. It is metabolized partially in the liver to N-methyl-1,3-propanediamine. It is excreted unchanged through the intestines (about 93%), 7% is excreted by the kidneys unchanged or as a metabolite.
From the digestive system: nausea, vomiting, diarrhea, anorexia, increased activity of hepatic transaminases.
From the side of the central nervous system and peripheral nervous system: headache, hallucinations, confusion, paresthesia, dizziness, drowsiness or insomnia.
Dermatological reactions: skin rash, urticaria.
Others: hearing impairment, hyperthermia.
special instructions Pyrantel:
Use with caution in liver failure.
After taking, laxatives are not prescribed.
With enterobiasis, simultaneous treatment of all persons living together should be carried out. After completion of treatment, it is necessary to conduct a control study of feces for the presence of parasite eggs.
It is prescribed with caution to children under 6 months of age.
In case of liver dysfunction
Use with caution in liver failure.
Application during pregnancy and lactation
Pirantel is contraindicated in pregnancy.
If necessary, use during lactation should decide on the termination of breastfeeding.
Drug interactions Pyrantel:
Should not be administered concomitantly with piperazine (weakening).
With the simultaneous use of increases the concentration of theophylline in plasma.
How to use Pyrantel:
The medicine is prescribed orally during or after a meal and the dosage is set individually depending on the age and body weight of the patient.
Ascariasis and enterobiasis, as well as mixed infestations - a single dose of 10 mg / kg body weight.
Children 3 years - 6 years old - 250 mg (1 tablet)
Children 6 years - 12 years old - 500 mg (2 tablets)
Children over 12 years old and adults weighing less than 75 kg - 750 mg (3 tablets)
Adults weighing over 75 kg - 1000 mg (4 tablets)
Ankylostomiasis: the drug is prescribed at the rate of 10 mg / kg body weight per day for 3 days.
Necatorosis: in severe forms, the drug is prescribed at a dose of 20 mg / kg of body weight per day for 2 days
