Tinidazole 500 mg 4 tablets

Tinidazole 500 mg 4 tablets

SKU:176
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Active substance:Tinidazole
Pharmacological group:Antibiotic
Formulation:Tablets
Dosage mg:500
In stock
$15
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Instructions for Tinidazole

Composition Tinidazole:

Tinidazole 500mg;
Auxiliaries: MCC,
potato starch,
povidone,
croscarmellose sodium,
magnesium stearate,
macrogol,
titanium dioxide,
talc

Pharmacodynamics Tinidazole:

Antiprotozoal agent with antibacterial effect. The mechanism of action is due to inhibition of synthesis and damage to the DNA structure of pathogens. Active against Trichomonas vaginalis, Entamoeba histolytica, Lamblia intestinalis.

It has a bactericidal effect against the following anaerobic bacteria: Bacteroides spp. (including Bacteroides fragilis, Bacteroides melaninogenicus), Clostridium spp., Eubacterium spp., Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp., Veillonella spp.

Pharmacokinetics Tinidazole:

Tinidazole has a high degree of absorpt

Penetrates through the BBB and the placental barrier. It is excreted in breast milk within 72 hours after administration. It is metabolized in the liver with the formation of pharmacologically active hydroxylated derivatives that inhibit the growth of anaerobic microorganisms and can enhance the effect of antibiotics. T1 / 2 - 12-14 hours. 50% is excreted with bile, 25% (unchanged) and 12% (in the form of metabolites) are excreted by the kidneys due to reverse absorption in the renal tubules.

Side effects Tinidazole:

From the digestive system: anorexia, dry oral mucosa, metallic taste in the mouth, nausea, vomiting, diarrhea.

From the side of the central nervous system and peripheral nervous system: headache, dizziness, fatigue, impaired coordination of movements (including locomotor ataxia), dysarthria, peripheral neuropathy; rarely - cramps, weakness. Allergic reactions: urticaria, pruritus, skin rash, angioedema. Other: transient leukopenia.

Special conditions Tinidazole:

In the treatment of trichomoniasis, simultaneous treatment of both partners should be carried out. If adverse reactions from the central nervous system occur, tinidazole should be discontinued.

During treatment, you should refrain from drinking alcohol. When using antibiotics, dark staining of the urine is observed.

If treatment lasts more than 6 days, regular monitoring of the peripheral blood picture should be carried out.

For the prevention of postoperative anaerobic infections, doses for children under 12 years of age have not been established. Influence on the ability to drive vehicles and control mechanisms During treatment, patients should refrain from engaging in potentially hazardous activities that require increased attention and high speed of psychomotor reactions.

Indications Tinidazole:

Trichomoniasis, giardiasis, amoebiasis (including the liver form), infections caused by anaerobic bacteria, mixed aerobic-anaerobic infections (in combination with antibiotics), eradication of Helicobacter pylori (in combination with bismuth preparations and antibiotics).

Prevention of postoperative anaerobic infections.

Contraindications Tinidazole:

Organic diseases of the central nervous system, hematopoiesis, I trimester of pregnancy, lactation (breastfeeding), hypersensitivity to tinidazole or other 5-nitroimidazole derivatives

With simultaneous use with ethanol, the development of a disulfiram-like effect cannot be ruled out

Dosage Tinidazole:

Individual. Adults - 1.5-2 g 1 time /; children (except for the prevention of postoperative anaerobic infections) - 50-75 mg / kg 1 time / Duration of treatment is determined by the clinical situation and can be 1-10 days.

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