Composition:
1 ml tobramycin (in the form of sulfate) 3 mg dexamethasone (in the form of sodium phosphate) 1 mg Excipients: benzalkonium chloride, disodium EDTA, disodium hydrogen phosphate dihydrate, sodium metabisulfite, sodium chloride, creatine, propylene glycol, purified water, sodium hydroxide or sulfuric acid (to maintain the pH level). Pharmacodynamics Broad-spectrum antibacterial, local anti-inflammatory.
Tobramycin (generation II aminoglycoside) blocks the 30-S subunit of the ribosomes and stops protein synthesis, at higher concentrations it disrupts the function of the cytoplasmic membranes, causing cell death. It is active against gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Citrobacter spp., Enterobacter spp.) And gram-negative bacteria (Escherichia coli, Klebsiella spp., Morganella morganii, Pseudomonas aeruginosa, Proteus mirabispprat. )
Dexamethasone (fluorinated glucocorticoid), interacts with specific cytoplasmic receptors, forms a complex that penetrates the cell nucleus and stimulates mRNA synthesis.
Prevents the release of inflammatory mediators from eosinophils and mast cells. It reduces the activity of hyaluronidase, collagenase, proteases and capillary permeability, stabilizes cell membranes, has anti-inflammatory, anti-allergic and immunosuppressive effects, local antipruritic and vasoconstrictor effects.
Side effects:
Local allergic reactions: swelling and itching of the eyelids, conjunctival erythema.
From the side of the organ of vision: with prolonged use - increased intraocular pressure; with continuous use for more than 3 months - the development of cataracts, mycosis of the cornea. Possible slowdown of regeneration processes.
Special conditions:
When applying for more than 10 days, it is necessary to regularly measure intraocular pressure. During treatment, wearing soft contact lenses is prohibited. When using hard lenses, they should be removed before instillation and put on again 15–20 minutes after the procedure.
Patients in whom the clarity of vision is temporarily lost after application is not recommended to drive a car or work with complex equipment immediately after instillation of the drug. The bottle must be closed after each use. Do not touch the tip of the pipette to the eye.
Indications:
- blepharitis;
- conjunctivitis;
- blepharoconjunctivitis;
- keratitis (without damage to the epithelium).
- prevention of postoperative infectious complications.
Contraindications:
- viral diseases of the cornea and conjunctiva (including keratitis caused by Herpes simplex, chicken pox);
- eye tuberculosis;
- fungal diseases of the eyes;
- conditions after removal of a foreign body of the cornea;
- Hypersensitivity to the components of the drug.
Dosage:
Assign 1-2 drops to the conjunctival sac of the affected eye (or eyes) every 4-6 hours. In severe infections, the drug is prescribed 2 drops every hour until the clinical effect is obtained, after which the dose is gradually reduced until the cessation of use.
