Instructions for Vibrocil
Vibrocil Pharmacological:
properties Vibrocil Vibrocil is a combined preparation containing phenylephrine and dimethindene.
The drug reduces nasal discharge and helps to cleanse the nasal passages without disturbing the physiological functions of the flickering epithelium and nasal mucosa.
Phenylephrine belongs to the sympathomimetic amines. It is used as a nasal decongestant with a moderate vasoconstrictor effect, selectively stimulates the α-adrenergic receptors of the cavernous venous tissue of the nasal mucosa.
Thus, swelling of the nasal mucosa and its paranasal sinuses is quickly and permanently eliminated.
Dimetindene, an antagonist of H 1 receptors, has an antiallergic effect, is effective when used in low doses, and is well tolerated.
/Vibrocil is applied topically, so its activity does not correlate with the concentration of active substances in the blood plasma.
With accidental oral absorption, the bioavailability of phenylephrine decreased and amounted to about 38%, the half-life was about 2.5 hours.
The systemic bioavailability of dimethindene after oral administration in solution is about 70%, the half-life is about 6 hours.
Indications Vibrocil:
Symptomatic treatment for colds, nasal congestion, acute and chronic rhinitis , seasonal (hay fever) and perennial allergic rhinitis , acute and chronic sinusitis, vasomotor rhinitis . Adjunctive therapy for acute otitis media.
Preparation for surgery in the nasal area and elimination of edema of the nasal mucosa and paranasal sinuses after surgery.
Vibrocil nasal gel is indicated in case of dryness of the nasal mucosa, in the presence of crusts due to trauma to the nose, as well as to prevent nasal congestion at night during sleep.
Application Vibrocil:
Before administering the drug, you should thoroughly clean the nose.
Nasal drops . Children under the age of 1 year (as recommended by a doctor): 1 drop in each nasal passage 3-4 times a day.
Children aged 1 to 6 years: 1-2 drops in each nasal passage 3-4 times a day.
Adults and children over the age of 6: 3-4 drops in each nasal passage 3-4 times a day.
Nasal gel. Adults and children over the age of 6 years: a small amount of the gel is injected as deep as possible into each nasal passage 3-4 times a day. It is recommended that the last application of the gel be done before bedtime.
Nasal spray. Adults and children over the age of 6 years: 1-2 injections into each nasal passage 3-4 times a day. The bottle should be held vertically with the spray upwards. Keeping the head straight, insert the tip of the bottle into the nasal passage, squeeze the nebulizer once with a short sharp movement and, pulling it out of the nose, unclench it. During the injection, a gentle inhalation through the nose is recommended.
The duration of treatment should not exceed 7 days and depends on the severity of the disease.
Contraindications Vibrocil:
Hypersensitivity to any component of the drug; due to the content of phenylephrine , like other vasoconstrictor drugs, it is contraindicated in atrophic rhinitis , as well as in patients taking MAO inhibitors, or taking them for the previous 14 days.
The preparation in the form of a gel and a spray is not recommended for children under 6 years of age. It is not recommended to take Vibrocil during pregnancy and lactation.
Side effects Vibrocil:
Usually the drug is well tolerated. In some cases, mild and transient local reactions from the nasal mucosa (burning sensation or dryness) are possible.
special instructions Vibrocil:
Vibrocil should not be used for more than 1 week. Prolonged or excessive use of the drug can cause tachyphylaxis and a rebound effect (rhinitis medicamentosa).
As with the use of other vasoconstrictor drugs, the recommended dose of the drug should not be exceeded. Excessive use of Vibrocil, especially in children and the elderly, can cause manifestations of the systemic effect of the drug.
Care should be taken to prescribe the drug to patients with cardiovascular diseases, patients with hypertension, thyroid diseases and people with angle-closure glaucoma.
During pregnancy and breastfeeding. The drug is not prescribed.
Influence on the ability to drive vehicles and work with mechanisms . Does not affect.
Interactions Vibrocil:
The drug is contraindicated in patients taking MAO inhibitors or taking them in the previous 14 days.
Vasoconstrictors should be used with caution in patients taking tricyclic antidepressants and antihypertensive drugs such as β-adrenergic receptor blockers.
Overdose Vibrocil
In case of accidental oral administration of the drug to young children, no serious side effects have been reported.
Most cases were asymptomatic; very rarely, fatigue, stomach pain, mild tachycardia, increased blood pressure, agitation, insomnia, pallor of the skin were reported.
Treatment Vibrocil The use of activated charcoal, laxatives in young children (gastric lavage is not required); adults and children are prescribed plenty of fluids.