Instructions for Aceclofenac pills
Release Form:
tab., film cover, 100 mg: 10, 20, 30, 40, 60 or 90 pcs.
Description:
Pills covered with a film shell of white or almost white color, round, double-bulged; On the cross-section of the kernel of white or almost white color.
1 tab
aceclophenac 100 mg
Auxiliary substances:
cellulose microcrystalline (type 101) - 89.2 mg,
povidon (Collidon 25 or Collidon 30, Plasdon K-25, or Plasdon K-29/30) - 6 6 mg,
sodium cross-carmellosis - 6.6 mg,
distearat glyceryl - 2.6 mg.
Composition of the membrane:
PM-1P-000 white vivacoate - 6 mg (hypromellosis - 3 mg, macrogol 3350 (polyethylene glycol 3350) - 0.3 mg,
hyprolosis - 0. 3 mg,
thalk - 0.6 mg,
titanium dioxide - 1.8 mg.
Pharmacological groups / Group membership
NPCS
Active substance:
Aceclofenac
Pharmaceuticals
PNBC, a derivative of phenylacetic acid. It has anti-inflammatory, analgesic and heat-reducing effects associated with the suppression of EGR 1 and 2, regulating the synthesis of prostaglandins.
Indications Aceclofenac:
inflammatory diseases of the musculoskeletal system, including rheumatoid arthritis, psoriatic and juvenil arthritis, ankilosic spondyloarthritis; gout arthritis, osteoartrosis.
Method of application, course and dosage:
Intra - 100 mg 1 time/day.
Outside - are applied to the area of engagement 3 times/day.
Drug Interaction Aceclofenac:
At the same time, aceclophenac increases the concentration of digoxine, lithium and phenytoin in plasma.
Against the background of simultaneous intake of potash-saving diuretics, the risk of hyperkalaemia is increased, against the background of anticoagulants - the risk of bleeding (it is necessary to regularly check the taper of blood).
Aceclofenac reduces the effects of diuretic and antihypertensive agents.
At the same time, the application of aceclophenac increases the risk of the development of side effects of NHF and HHS by LCD, the toxicity of methotroxate (interval between receptions - 24 hours) and the petrotoxicity of cyclosporine.
Acethylsalic acid reduces the concentration of aceklophenac in the blood.
When simultaneously used with oral hypoglycemics, both hypo- and hyperglycemia are possible (glucose level control in the blood is necessary).
Use in pregnancy and breastfeeding:
Contradicted use during pregnancy and lactation (breastfeeding).
Aceclofenac is contraindicated to use in the III trimester of pregnancy.
In I and II trimesters of pregnancy and lactation aceclophenac are prescribed with care only in cases where the expected therapeutic effect for the mother exceeds the potential risk for the fetus or the infant.
The drug Aceclofenac is contraindicated for use during pregnancy and during breastfeeding.
Clinical data on the use of Aertal during pregnancy are not available. Regular use of NPH in the third trimester of pregnancy can result in reduced tone and weaker uterine abatement. The application of NPHS may lead to premature closure of the protocracy of the botalite in the fetus and possibly to long-term lung hypertension in the newborn, delay in the start of childbirth and increase in the duration of childbirth.
Epidemiological studies in humans have not produced data indicating the embryotoxicity of NWHA. However, in the experimental studies on rabbits for the introduction of aceclophenac (10 mg/kg/day), morphological changes in the fetus were observed in some cases. There is no evidence of teratogenic effect in rats.
Data on the allocation of aceclophenac with breast milk are not available. In experimental studies, when introducing a radioactive 14C-aceclophenac, lactating rats did not show a noticeable transfer of radioactivity into milk.
NPHS is capable of affecting fertility and is not recommended for use by women planning pregnancy.
Side Action Aceclofenac:
From the digestive system: gastralgia, nausea, vomiting, dyspepsia, meteorism, anorexia, increased activity of liver transamysis, gastrointestinal hemorrhage, erosive-ulcer lesions and perphsions LCD, hematemesis, melena, lightning hepatitis, constipation.
On the side of the CNS and the peripheral nervous system: headaches, dizziness, arousal, perceptual, pastesthesia, memory loss, disorientation, vision, hearing and taste disorders, ear noise, sleep disorders (sleepiness or insomnia), irritation, judgment And, depression, anxiety, tremor, aseptic meningitis.
Allergic reactions: skin rash; Rarely - nettle, eczema, multiform erythema, erythrodermia, system anaphylactic reactions, bronchial asthma, in some cases - vasculitis, pneumonite, maliic exologate erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome).
On the side of the urinary system: rarely peripheral swelling; In some cases - acute kidney failure, hematuria, proteinuria, interstitial jade, nephrotic syndrome.
On the side of the blood-producing system: thrombocytopenia, leukopenia, agranulocytosis, hemolytic anemia, aplastic anemia.
On the side of the cardiovascular system: tachycardia, AD enhancement, chronic heart failure.
Contraindications to use:
Erosive-ulcerous LCD lesions (acute), gastrointestinal bleeding or suspicion, "aspirin triad" (combination of bronchial asthma, recurrent polyposis) and paronosial sinuses and intolerability of acetylsalic acid and pyrazolon-grade preparations), blood disturbances of unclear etiology, blood folding disorders, liver failure or active liver disease, expressed in soil Ear failure, progressive kidney diseases, hyperkalemia, post-aorthocoronary bypass, pregnancy, child and adolescent age up to 18 years, for external use - a violation of the integrity of skin cover at the place of application; high sensitivity to aceclophenac.
Special Instructions Aceclofenac:
Use with care in liver, kidney and LCD diseases in anamnesis, bronchial asthma, arterial hypertension, IBS, indications in anamnesis for the development of ulcerous LCD lesions, if there is infection Helicobacter pylori, cerebrovascular diseases, dyspydia/hyperlipidemia, diabetes mellitus, peripheral artery diseases, smokers, elderly patients, long-term NPHS, frequent alcohol consumption, severe somatic diseases.
Prostaglandians play an important role in maintaining kidney blood flow, so special care should be taken when assigning patients with heart or kidney failure, elderly people taking diuretics, and patients suffering from a decline in the CCS for any reason (e.g. after a large surgeon) (a) If aceclophenacs are prescribed in such cases, it is recommended that the kidney function be monitored as a precautionary measure. In patients with liver failure (chronic hepatitis, compensated liver cirrhosis) kinetics and metabolism are not different from similar processes in patients with normal liver function. For long-term therapy
Application for kidney disorders Aceclofenac
Contravenous insufficiency, progressive kidney diseases.
Use with care for kidney diseases in anamnesis.
Due to the important role of prostaglandins in maintaining kidney blood flow, special care should be taken when assigning patients with moderate kidney failure.
Application for liver disorders:
Contravenous in active liver disease.
Use with care for liver diseases in anamnesis.
In patients with liver failure (chronic hepatitis, compensated liver cirrhosis) kinetics and metabolism are not different from similar processes in patients with normal liver function. During long-term therapy it is necessary to control the liver function, the picture of peripheral blood, the analysis of the fila for hidden blood.
Application of elderly patients
Special care should be taken when assigning elderly patients.
Application of children
Contradicted: Children and teenagers under 18 years of age.
Nozology (ICD codes)
Seroppositive rheumatoid arthritis
Psoriatic and enteropathic arthropathy
Young [Juvenile] arthritis
Podagra
Polyarthrosis
Ankilositive Spondilitis
Spondiles
