Instructions for Actovegin
Dosage forms and their composition:
The drug is available in various dosage forms - tablets, ointment, cream, gel, solutions for infusion and injection. The price of dosage forms is not the same. The most expensive are tablets; creams and ointments are much cheaper.
Actovegin tablets ACTOVEGIN:
Tablets are prescribed for circulatory disorders, treatment of trophic ulcers, encephalopathy, the consequences of traumatic brain injury. Taking pills is more convenient and has a lower risk of side effects than parenteral administration of the drug.
Actovegin is available in several pharmaceutical forms:
ampoules for injection, ointment, gel or tablets. In this article we will consider a drug in the form of a solution for intramuscular or intravenous injection. Before buying a drug, it is important to pay attention to the dose.
0.4 mg, 5 ampoules in a package of 10 ml;
200 mg solution, 5 ml ampoules # 5;
80 mg each, ampoules No. 25, 2 ml each.
The drug is often combined with other drugs.
There is no data on drug incompatibility.
Reviews of doctors, as well as of the patients themselves, who treated Actovegin are very positive. Many people note the high efficiency and good tolerance of the drug after several days of use. The solution for injections is best used in a hospital setting, but it can be used on an outpatient basis, and only a medical officer with extensive experience can administer the medicine.
The main component is deproteinized hemoderivat with a dosage of 40 mg of Actovegin per 1 ml of solution for injection. It is obtained from the blood of healthy calves that feed exclusively on milk. The drug is produced in tablets, ointments and gels, ampoules for injections and solutions for droppers. In addition to the main component, the solution contains sodium chloride and water for injection.
The outer packaging for ampoules is made of cardboard, the inner one is a plastic container. The production series and expiration date are indicated on the carton. The package contains instructions (manual) for use. The clear solution has a yellowish color with different shades depending on the release batch. The color of the drug does not in any way affect the effectiveness of the drug.
In the pharmacy, you can also buy Actovegin in 250 ml dropper bottles:
based on dextrose with 10% active ingredient;
on saline with 10 and 20 percent hemoderivat content.
side effects ACTOVEGIN:
ACTOVEGIN solution contains an active ingredient - actovegin, obtained from the blood of calves, and water for injection. In terms of dry deproteinized hemoderivat of calf blood, one ampoule with a volume of 2 ml contains 80 mg of the main ingredient, 5 ml - 200 mg, 10 ml - 400 mg. The ACTOVEGIN concentrate contains sodium chloride in the form of sodium and chlorine ions, which are components of the blood of calves. Sodium chloride is not added or removed during the concentrate production process.
ACTOVEGIN solution for infusion is available in the form of 10% and 20% solution of calf blood extract purified from protein in 0.9% sodium chloride solution. A 250 ml solution contains 25 ml or 50 ml of the main component, which corresponds to 1.0 or 2.0 g of dry mass. The content of ACTOVEGIN ampoules is a clear yellowish liquid.
Actovegin injections are made in order to improve the transport and utilization of glucose, to stimulate oxygen consumption. There is a stabilization of the plasma membranes of cells during ischemia, the formation of lactate decreases. The antihypoxic effect of ACTOVEGIN begins to manifest itself at the latest 30 minutes after an intramuscular or intravenous injection and reaches a maximum after an average of 3 hours.
The medicine is made from natural ingredients, so the likelihood of any side effects is extremely small. However, in some cases there are:
- soreness at the injection site
- hyperemia of the skin
- anaphylactic shock
- pain in the stomach
- hypertension or hypotension
- increased sweating
When using ointments and creams to heal wounds, there can often be soreness where the drug touches the skin. Such pains usually disappear within 15-30 minutes and do not indicate intolerance to the drug.
It is not recommended to use the medicine at the same time as alcohol, as the latter can neutralize the therapeutic effect.
At the moment, there is no data on the interaction of ACTOVEGIN with other drugs. It is not recommended to add foreign substances to the infusion solution.
Oliguria or anuria
Decompensated heart failure
Intolerance to components
The drug is well tolerated, but in rare cases, after the administration of the drug, side reactions of the body may appear:
pain in the area of the injection;
rash on the body;
The medicine does not have a toxic effect on the body, is not addictive. If the patient has an increased sensitivity to ACTOVEGIN
When using the drug ACTOVEGIN intramuscularly, intravenously, intraarterially or orally, the following adverse reactions may occur:
increased body temperature;
redness and swelling of the skin;
Such effects are rare and are often associated with hypersensitivity to the components of the medication. In these cases, it is necessary to stop taking the drug and consult a doctor. When using external forms of the drug in the area of application, reactions in the form of itching and burning are possible. Sometimes at the beginning of therapy, local pain reactions occur, which soon pass on their own and are not a reason for canceling Actovegin. Eye gel can give such undesirable reactions as increased lacrimation, reddening of the sclera.
Description and composition:
ACTOVEGIN is a drug with a broad spectrum of antihypoxant and antioxidant effects. The basic principle of the drug's action is based on tissue regeneration. The drug improves blood circulation, provides the brain tissue with the necessary amount of oxygen and other useful components. Actovegin can be used in the complex treatment of many diseases.
The active ingredient of the drug is a deproteinized hemoderivat of calf blood 50 mg, as well as auxiliary components, including sodium chloride, water for injection.
The drug ACTOVEGIN has earned the trust of doctors and patients as a reliable remedy. It is well tolerated by both adults and children. And even the relatively high price of the medicine is not a hindrance to this. For example, the average price for a pack of 50 tablets is about 1,500 rubles. Such a high price is due to both the complexity of the preparation technology and the fact that it is manufactured by a foreign manufacturer - an Austrian pharmaceutical company. And at the same time, the drug is in demand, which means that Actovegin is an effective remedy.
What does the drug help from? The main purpose of the drug is the treatment of diseases associated with blood circulation. Ointments are widely used to treat bruises, abrasions, and pressure sores. Also, the drug is used to treat diseases associated with circulatory disorders.
- Metabolic and vascular disorders of the brain in ischemic stroke
- traumatic brain injury
- various types of dementia
- Arterial and venous vascular disorders and their consequences
- Diabetic polyneuropathy
- Long-term healing wounds and ulcers of various origins
- The drug is used for the prevention and treatment of radiation damage to the skin and mucous membranes during radiation therapy.
- According to the instructions for use, ACTOVEGIN injections are not given in case of hypersensitivity to the drug and analogues, heart failure in the stage of decompensation, pulmonary edema, a decrease in urine production or cessation of its flow into the bladder, fluid retention in the body.
- Injections of Actovegin solution to pregnant and breastfeeding women do not cause toxic effects on the fetus and newborn.
Do not give Mexidol and Actovegin injections at the same time.
The use of ACTOVEGIN during pregnancy:
Quite often, the course of Actovegin is prescribed to pregnant women as part of complex treatment for placental insufficiency, the threat of premature birth and spontaneous miscarriage, intrauterine growth retardation and placenta previa.
Thanks to injections, droppers and Actovegin tablets, blood flow improves in the smallest capillaries and veins, which deliver nutrients from the mother's body to the fetus and transport waste products in the opposite direction. A feature of the drug is the fact that it is practically harmless to the child, since it does not penetrate the placenta.
For the prevention of placental insufficiency or with its minor manifestations, Actovegin tablets are prescribed to pregnant women. In difficult cases, Actovegin is most often used in injections or droppers.
The dosage form, duration of administration and dosage of the drug depend on the severity of the disease and the condition of the woman and are selected by the doctor individually in each case. At the same time, Actovegin during pregnancy is approved for use at any time.
Pharmacological group ACTOVEGIN:
ACTOVEGIN in ampoules activates metabolic processes, increases the transport and accumulation of glucose to the brain. The drug restores the concentration of amino acids, ADP, ATP, stimulates the utilization of glucose. The use of the drug stabilizes the plasma membranes, improves the energy balance in the tissues.
The antihypoxic effect of the drug appears within 30 minutes after parenteral administration and lasts for 3 to 6 hours. Actovegin has the ability to heal tissues at the intracellular level, improve blood supply to the structures of the brain. The principle of action of the drug increases the resistance of tissues and internal organs to oxygen starvation.
ACTOVEGIN belongs to multicomponent preparations, which contains various compounds that have a positive effect on the human body. The drug has been on the market for more than 10 years and is often used to treat diseases accompanied by metabolic disorders.
3. ARTEMIDA Trial (A Randomized Trial of Efficacy, 12 Months International Double-Blind Actovegin): A Randomized Controlled Trial to Assess the Efficacy of Actovegin in Poststroke Cognitive Impairment